IJMDC. 2021; 5(5): 1244-1247

Genetic basis of Parkinson's disease: a brief review

Authors: Anas Sulaiman Aljohani, Alhassan Abdulnasser Mawlan Ahmed, AbdulBaqi Mansour Bukhary, Syed Imam Nazar.

ABSTRACT

Parkinson's disease (PD) is characterized by rigidity, resting tremor, instability, and bradykinesia. Although not necessarily heritable, Parkinson may run in families in specific combinations of mutations in certain genes. In this review, we aim to summarize the list of genes that are involved in the inheritance of PD. The online databases such as PubMed, ScienceDirect, and UpToDate were used to carry out a literature search for publications without any date or language restrictions. We used a combination of relevant search terms and identified publications and systematically screened titles, abstracts, and full texts of the collected publications. The study found that SNCA and leucine-rich repeat kinase 2 (LRRK2) genes may cause dominant expressions, while PINK1, DJ11, and PARKIN cause a recessive expression. The GBA and MAPT genes were reported as genetic risk factors in most of the studies.

Keywords:
Parkinson, genetic, SNCA, LRRK2, PARKIN, GBA, PINK1.


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Genetic basis of Parkinson's disease: a brief review


Authors
Anas Sulaiman Aljohani
Taibah University, College of Medicine, Almadinah Almunawwarah, Saudi Arabia
PubMed articlesGoogle scholar articles

Alhassan Abdulnasser Mawlan Ahmed
Taibah University, College of Medicine, Almadinah Almunawwarah, Saudi Arabia
PubMed articlesGoogle scholar articles

AbdulBaqi Mansour Bukhary
Taibah University, College of Medicine, Almadinah Almunawwarah, Saudi Arabia
PubMed articlesGoogle scholar articles

Syed Imam Nazar
Taibah University, College of Medicine, Almadinah Almunawwarah, Saudi Arabia
PubMed articlesGoogle scholar articles


Correspondence to:
. Taibah University, College of Medicine, Almadinah Almunawwarah, Saudi Arabia.; anas.aljohani1997@gmail.com

Publication history
Received 08 Feb 2021
Accepted 07 Apr 2021
Published online 23 Apr 2021
Published in print 06 Jun 2021

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Pubmed Style

Aljohani AS, Ahmed AAM, Bukhary AM, Nazar SI. Genetic basis of Parkinson's disease: a brief review. IJMDC. 2021; 5(5): 1244-1247. doi:10.24911/IJMDC.51-1612790077


Web Style

Aljohani AS, Ahmed AAM, Bukhary AM, Nazar SI. Genetic basis of Parkinson's disease: a brief review. https://www.ijmdc.com/?mno=53649 [Access: July 25, 2021]. doi:10.24911/IJMDC.51-1612790077


AMA (American Medical Association) Style

Aljohani AS, Ahmed AAM, Bukhary AM, Nazar SI. Genetic basis of Parkinson's disease: a brief review. IJMDC. 2021; 5(5): 1244-1247. doi:10.24911/IJMDC.51-1612790077


Vancouver/ICMJE Style

Aljohani AS, Ahmed AAM, Bukhary AM, Nazar SI. Genetic basis of Parkinson's disease: a brief review. IJMDC. (2021), [cited July 25, 2021]; 5(5): 1244-1247. doi:10.24911/IJMDC.51-1612790077


Harvard Style

Aljohani, A. S., Ahmed, . A. A. M., Bukhary, . A. M. & Nazar, . S. I. (2021) Genetic basis of Parkinson's disease: a brief review. IJMDC, 5 (5), 1244-1247. doi:10.24911/IJMDC.51-1612790077


Turabian Style

Aljohani, Anas Sulaiman, Alhassan Abdulnasser Mawlan Ahmed, AbdulBaqi Mansour Bukhary, and Syed Imam Nazar. 2021. Genetic basis of Parkinson's disease: a brief review. International Journal of Medicine in Developing Countries, 5 (5), 1244-1247. doi:10.24911/IJMDC.51-1612790077


Chicago Style

Aljohani, Anas Sulaiman, Alhassan Abdulnasser Mawlan Ahmed, AbdulBaqi Mansour Bukhary, and Syed Imam Nazar. "Genetic basis of Parkinson's disease: a brief review." International Journal of Medicine in Developing Countries 5 (2021), 1244-1247. doi:10.24911/IJMDC.51-1612790077


MLA (The Modern Language Association) Style

Aljohani, Anas Sulaiman, Alhassan Abdulnasser Mawlan Ahmed, AbdulBaqi Mansour Bukhary, and Syed Imam Nazar. "Genetic basis of Parkinson's disease: a brief review." International Journal of Medicine in Developing Countries 5.5 (2021), 1244-1247. Print. doi:10.24911/IJMDC.51-1612790077


APA (American Psychological Association) Style

Aljohani, A. S., Ahmed, . A. A. M., Bukhary, . A. M. & Nazar, . S. I. (2021) Genetic basis of Parkinson's disease: a brief review. International Journal of Medicine in Developing Countries, 5 (5), 1244-1247. doi:10.24911/IJMDC.51-1612790077


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