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2024, Vol: 8, Issue: 4
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Review Article

Online Publishing Date:
23 / 04 / 2021

 


Genetic basis of Parkinson's disease: a brief review

Anas Sulaiman Aljohani, Alhassan Abdulnasser Mawlan Ahmed, AbdulBaqi Mansour Bukhary, Syed Imam Nazar.


Abstract
Parkinson's disease (PD) is characterized by rigidity, resting tremor, instability, and bradykinesia. Although not necessarily heritable, Parkinson may run in families in specific combinations of mutations in certain genes. In this review, we aim to summarize the list of genes that are involved in the inheritance of PD. The online databases such as PubMed, ScienceDirect, and UpToDate were used to carry out a literature search for publications without any date or language restrictions. We used a combination of relevant search terms and identified publications and systematically screened titles, abstracts, and full texts of the collected publications. The study found that SNCA and leucine-rich repeat kinase 2 (LRRK2) genes may cause dominant expressions, while PINK1, DJ11, and PARKIN cause a recessive expression. The GBA and MAPT genes were reported as genetic risk factors in most of the studies.

Key words: Parkinson, genetic, SNCA, LRRK2, PARKIN, GBA, PINK1.


 
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How to Cite this Article
Pubmed Style

Aljohani AS, Ahmed AAM, Bukhary AM, Nazar SI. Genetic basis of Parkinson's disease: a brief review. IJMDC. 2021; 5(5): 1244-1247. doi:10.24911/IJMDC.51-1612790077

Web Style

Aljohani AS, Ahmed AAM, Bukhary AM, Nazar SI. Genetic basis of Parkinson's disease: a brief review. https://www.ijmdc.com/?mno=53649 [Access: March 26, 2024]. doi:10.24911/IJMDC.51-1612790077

AMA (American Medical Association) Style

Aljohani AS, Ahmed AAM, Bukhary AM, Nazar SI. Genetic basis of Parkinson's disease: a brief review. IJMDC. 2021; 5(5): 1244-1247. doi:10.24911/IJMDC.51-1612790077


Vancouver/ICMJE Style

Aljohani AS, Ahmed AAM, Bukhary AM, Nazar SI. Genetic basis of Parkinson's disease: a brief review. IJMDC. (2021), [cited March 26, 2024]; 5(5): 1244-1247. doi:10.24911/IJMDC.51-1612790077


Harvard Style

Aljohani, A. S., Ahmed, . A. A. M., Bukhary, . A. M. & Nazar, . S. I. (2021) Genetic basis of Parkinson's disease: a brief review. IJMDC, 5 (5), 1244-1247. doi:10.24911/IJMDC.51-1612790077


Turabian Style

Aljohani, Anas Sulaiman, Alhassan Abdulnasser Mawlan Ahmed, AbdulBaqi Mansour Bukhary, and Syed Imam Nazar. 2021. Genetic basis of Parkinson's disease: a brief review. International Journal of Medicine in Developing Countries, 5 (5), 1244-1247. doi:10.24911/IJMDC.51-1612790077


Chicago Style

Aljohani, Anas Sulaiman, Alhassan Abdulnasser Mawlan Ahmed, AbdulBaqi Mansour Bukhary, and Syed Imam Nazar. "Genetic basis of Parkinson's disease: a brief review." International Journal of Medicine in Developing Countries 5 (2021), 1244-1247. doi:10.24911/IJMDC.51-1612790077


MLA (The Modern Language Association) Style

Aljohani, Anas Sulaiman, Alhassan Abdulnasser Mawlan Ahmed, AbdulBaqi Mansour Bukhary, and Syed Imam Nazar. "Genetic basis of Parkinson's disease: a brief review." International Journal of Medicine in Developing Countries 5.5 (2021), 1244-1247. Print. doi:10.24911/IJMDC.51-1612790077


APA (American Psychological Association) Style

Aljohani, A. S., Ahmed, . A. A. M., Bukhary, . A. M. & Nazar, . S. I. (2021) Genetic basis of Parkinson's disease: a brief review. International Journal of Medicine in Developing Countries, 5 (5), 1244-1247. doi:10.24911/IJMDC.51-1612790077




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