Anti-IL-17 markedly inhibited the in vitro granuloma induced by Schistosoma mansoni soluble egg antigen.

Asmaa Ezz; Irene S. Gmail; Fatma Elzahraa H. Salem; Rabab Salama; Soad Nady

doi:10.24911/IJMDC.2.1.7

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IJMDC. 2018; 2(January 2018): 38-46

doi: 10.24911/IJMDC.2.1.7

Anti-IL-17 markedly inhibited the in vitro granuloma induced by Schistosoma mansoni soluble egg antigen.

Asmaa Ezz, Irene S. Gmail, Fatma Elzahraa H. Salem, Rabab Salama, Soad Nady.

Abstract
IL-17 is a proinflammatory cytokine produced by T helper cells and is involved in the recruitment of white blood cells during the formation of granuloma induced by Schistosoma eggs. The aim of the present study was to examine the formation of in vitro granuloma induced by Schistosoma mansoni soluble egg antigen (SEA) after neutralization of IL-17 using Anti-IL-17 antibody. Peripheral blood mononuclear cells (PBMCs) were isolated from 20 S. mansoni monoinfected, 50 S. mansoni/Hepatitis C virus (HCV) coinfected patients and 25 healthy individuals. The isolated PBMCs were used for in vitro granuloma induction using S. mansoni SEA conjugated polyacrylamide beads. Different concentrations of Anti-IL-17 (0.5, 1, 2 or 4 ng/ml) were added to the cultured granuloma at the first day then the sizes of granuloma were assessed by granuloma index (GI) after 3, 7 or 14 days. Results revealed that, Anti-IL-17 at a concentration of 2 ng/ml optimally reduced the GI of the granuloma formed using PBMCs isolated from S. mansoni monoinfected, S. mansoni/HCV coinfected patients or healthy individuals after all the experimental time intervals. In conclusion, IL-17 blocking with the neutralizing Anti-IL-17 antibody promotes a marked reduction in the sizes of granuloma induced by S. mansoni SEA.

Key words: Peripheral blood mononuclear cells, Th-17 cells, IL-17 cytokine, Schistosoma mansoni, granuloma, Anti-IL-17 antibody.

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Pubmed Style

Ezz A, Gmail IS, Salem FEH, Salama R, Nady S. Anti-IL-17 markedly inhibited the in vitro granuloma induced by Schistosoma mansoni soluble egg antigen.. IJMDC. 2018; 2(January 2018): 38-46. doi:10.24911/IJMDC.2.1.7

Web Style

Ezz A, Gmail IS, Salem FEH, Salama R, Nady S. Anti-IL-17 markedly inhibited the in vitro granuloma induced by Schistosoma mansoni soluble egg antigen.. https://www.ijmdc.com/?mno=291092 [Access: January 23, 2025]. doi:10.24911/IJMDC.2.1.7

AMA (American Medical Association) Style

Ezz A, Gmail IS, Salem FEH, Salama R, Nady S. Anti-IL-17 markedly inhibited the in vitro granuloma induced by Schistosoma mansoni soluble egg antigen.. IJMDC. 2018; 2(January 2018): 38-46. doi:10.24911/IJMDC.2.1.7

Vancouver/ICMJE Style

Ezz A, Gmail IS, Salem FEH, Salama R, Nady S. Anti-IL-17 markedly inhibited the in vitro granuloma induced by Schistosoma mansoni soluble egg antigen.. IJMDC. (2018), [cited January 23, 2025]; 2(January 2018): 38-46. doi:10.24911/IJMDC.2.1.7

Harvard Style

Ezz, A., Gmail, . I. S., Salem, . F. E. H., Salama, . R. & Nady, . S. (2018) Anti-IL-17 markedly inhibited the in vitro granuloma induced by Schistosoma mansoni soluble egg antigen.. IJMDC, 2 (January 2018), 38-46. doi:10.24911/IJMDC.2.1.7

Turabian Style

Ezz, Asmaa, Irene S. Gmail, Fatma Elzahraa H. Salem, Rabab Salama, and Soad Nady. 2018. Anti-IL-17 markedly inhibited the in vitro granuloma induced by Schistosoma mansoni soluble egg antigen.. International Journal of Medicine in Developing Countries, 2 (January 2018), 38-46. doi:10.24911/IJMDC.2.1.7

Chicago Style

Ezz, Asmaa, Irene S. Gmail, Fatma Elzahraa H. Salem, Rabab Salama, and Soad Nady. "Anti-IL-17 markedly inhibited the in vitro granuloma induced by Schistosoma mansoni soluble egg antigen.." International Journal of Medicine in Developing Countries 2 (2018), 38-46. doi:10.24911/IJMDC.2.1.7

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Ezz, A., Gmail, . I. S., Salem, . F. E. H., Salama, . R. & Nady, . S. (2018) Anti-IL-17 markedly inhibited the in vitro granuloma induced by Schistosoma mansoni soluble egg antigen.. International Journal of Medicine in Developing Countries, 2 (January 2018), 38-46. doi:10.24911/IJMDC.2.1.7

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