Review Article
IJMDC. 2023; 7(4): 716-721
Monogenic forms of childhood obesity: a review
Authors: Sultan Yahya Asiri, Razan Thamer Alqarni, Njoud Khaled Alkhaldi, Njoud Naif Alharbi, Shaden Mohammed Alkhayal, Ghadeer Mohammed Alghamdi, Waad Khalid Alghamdi, Maram Abdullah Al-Taleb, Meshael Abdulmohsin Aldrees.
ABSTRACT
Childhood obesity has become a notable health concern in the world. According to American Medical Association, obesity is defined as having a body mass index greater than 30 kg/m2. Childhood obesity is classified into three main categories, polygenic obesity, which is the most common form; followed by monogenic obesity, which is rare; and non-syndromic obesity. The management of childhood obesity is complex and requires a multidisciplinary approach. For monogenic obesity, several treatment options have been investigated. Long-term body weight maintenance is challenging. This review aimed to provide an overview of monogenic obesity, its mechanisms, evaluation, and treatment options. Monogenic forms of childhood obesity are rare. However, early diagnosis using whole-exome sequencing is needed to identify the causes of obesity and its associated anomalies for subsequent treatment. In addition, the early initiation of a multidisciplinary management approach is essential to prevent long-term morbidity and mortality. Several new treatment options have recently emerged, which could, in combination with lifestyle modifications, provide a favorable outcome for patients with non-syndromic forms of obesity.
Keywords:
pediatrics, genetics, childhood, obesity
Authors
Sultan Yahya Asiri
Neonatology, Ministry of Health, Abha, Saudi Arabia
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Razan Thamer Alqarni
Department of Pediatrics, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia
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Njoud Khaled Alkhaldi
Department of Pediatrics, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia
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Njoud Naif Alharbi
Department of Pediatrics, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia
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Shaden Mohammed Alkhayal
Department of Pediatrics, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia
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Ghadeer Mohammed Alghamdi
Department of Pediatrics, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia
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Waad Khalid Alghamdi
Department of Pediatrics, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia
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Maram Abdullah Al-Taleb
Department of Pediatrics, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia
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Meshael Abdulmohsin Aldrees
Department of Pediatrics, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
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Correspondence to:
. Razan Thamer Alqarni, Department of Pediatrics, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.; Rtalqarni0@gmail.com
Publication history
Received 02 Jan 2023
Accepted 06 Jan 2023
Published online 06 Jan 2023
Published in print 15 Jan 2023
How to cite this article?
Export to EndNote Export to refManPubmed Style
Asiri SY, Alqarni RT, Alkhaldi NK, Alharbi NN, Alkhayal SM, Alghamdi GM, Alghamdi WK, Al-Taleb MA, Aldrees MA. Monogenic forms of childhood obesity: a review. IJMDC. 2023; 7(4): 716-721. doi:10.24911/IJMDC.51-1672675373
Web Style
Asiri SY, Alqarni RT, Alkhaldi NK, Alharbi NN, Alkhayal SM, Alghamdi GM, Alghamdi WK, Al-Taleb MA, Aldrees MA. Monogenic forms of childhood obesity: a review. https://www.ijmdc.com/?mno=135946 [Access: March 22, 2023]. doi:10.24911/IJMDC.51-1672675373
AMA (American Medical Association) Style
Asiri SY, Alqarni RT, Alkhaldi NK, Alharbi NN, Alkhayal SM, Alghamdi GM, Alghamdi WK, Al-Taleb MA, Aldrees MA. Monogenic forms of childhood obesity: a review. IJMDC. 2023; 7(4): 716-721. doi:10.24911/IJMDC.51-1672675373
Vancouver/ICMJE Style
Asiri SY, Alqarni RT, Alkhaldi NK, Alharbi NN, Alkhayal SM, Alghamdi GM, Alghamdi WK, Al-Taleb MA, Aldrees MA. Monogenic forms of childhood obesity: a review. IJMDC. (2023), [cited March 22, 2023]; 7(4): 716-721. doi:10.24911/IJMDC.51-1672675373
Harvard Style
Asiri, S. Y., Alqarni, . R. T., Alkhaldi, . N. K., Alharbi, . N. N., Alkhayal, . S. M., Alghamdi, . G. M., Alghamdi, . W. K., Al-Taleb, . M. A. & Aldrees, . M. A. (2023) Monogenic forms of childhood obesity: a review. IJMDC, 7 (4), 716-721. doi:10.24911/IJMDC.51-1672675373
Turabian Style
Asiri, Sultan Yahya, Razan Thamer Alqarni, Njoud Khaled Alkhaldi, Njoud Naif Alharbi, Shaden Mohammed Alkhayal, Ghadeer Mohammed Alghamdi, Waad Khalid Alghamdi, Maram Abdullah Al-Taleb, and Meshael Abdulmohsin Aldrees. 2023. Monogenic forms of childhood obesity: a review. International Journal of Medicine in Developing Countries, 7 (4), 716-721. doi:10.24911/IJMDC.51-1672675373
Chicago Style
Asiri, Sultan Yahya, Razan Thamer Alqarni, Njoud Khaled Alkhaldi, Njoud Naif Alharbi, Shaden Mohammed Alkhayal, Ghadeer Mohammed Alghamdi, Waad Khalid Alghamdi, Maram Abdullah Al-Taleb, and Meshael Abdulmohsin Aldrees. "Monogenic forms of childhood obesity: a review." International Journal of Medicine in Developing Countries 7 (2023), 716-721. doi:10.24911/IJMDC.51-1672675373
MLA (The Modern Language Association) Style
Asiri, Sultan Yahya, Razan Thamer Alqarni, Njoud Khaled Alkhaldi, Njoud Naif Alharbi, Shaden Mohammed Alkhayal, Ghadeer Mohammed Alghamdi, Waad Khalid Alghamdi, Maram Abdullah Al-Taleb, and Meshael Abdulmohsin Aldrees. "Monogenic forms of childhood obesity: a review." International Journal of Medicine in Developing Countries 7.4 (2023), 716-721. Print. doi:10.24911/IJMDC.51-1672675373
APA (American Psychological Association) Style
Asiri, S. Y., Alqarni, . R. T., Alkhaldi, . N. K., Alharbi, . N. N., Alkhayal, . S. M., Alghamdi, . G. M., Alghamdi, . W. K., Al-Taleb, . M. A. & Aldrees, . M. A. (2023) Monogenic forms of childhood obesity: a review. International Journal of Medicine in Developing Countries, 7 (4), 716-721. doi:10.24911/IJMDC.51-1672675373
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