Monogenic forms of childhood obesity: a review

Sultan Yahya Asiri; Razan Thamer Alqarni; Njoud Khaled Alkhaldi; Njoud Naif Alharbi; Shaden Mohammed Alkhayal; Ghadeer Mohammed Alghamdi; Waad Khalid Alghamdi; Maram Abdullah Al-Taleb; Meshael Abdulmohsin Aldrees

doi:10.24911/IJMDC.51-1672675373

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Review Article
Online Published: 06 Jan 2023

IJMDC. 2023; 7(4): 716-721

doi: 10.24911/IJMDC.51-1672675373

Monogenic forms of childhood obesity: a review

Sultan Yahya Asiri, Razan Thamer Alqarni, Njoud Khaled Alkhaldi, Njoud Naif Alharbi, Shaden Mohammed Alkhayal, Ghadeer Mohammed Alghamdi, Waad Khalid Alghamdi, Maram Abdullah Al-taleb, Meshael Abdulmohsin Aldrees.

Abstract
Childhood obesity has become a notable health concern in the world. According to American Medical Association, obesity is defined as having a body mass index greater than 30 kg/m2. Childhood obesity is classified into three main categories, polygenic obesity, which is the most common form; followed by monogenic obesity, which is rare; and non-syndromic obesity. The management of childhood obesity is complex and requires a multidisciplinary approach. For monogenic obesity, several treatment options have been investigated. Long-term body weight maintenance is challenging. This review aimed to provide an overview of monogenic obesity, its mechanisms, evaluation, and treatment options. Monogenic forms of childhood obesity are rare. However, early diagnosis using whole-exome sequencing is needed to identify the causes of obesity and its associated anomalies for subsequent treatment. In addition, the early initiation of a multidisciplinary management approach is essential to prevent long-term morbidity and mortality. Several new treatment options have recently emerged, which could, in combination with lifestyle modifications, provide a favorable outcome for patients with non-syndromic forms of obesity.

Key words: pediatrics, genetics, childhood, obesity

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Pubmed Style

Asiri SY, Alqarni RT, Alkhaldi NK, Alharbi NN, Alkhayal SM, Alghamdi GM, Alghamdi WK, Al-taleb MA, Aldrees MA. Monogenic forms of childhood obesity: a review. IJMDC. 2023; 7(4): 716-721. doi:10.24911/IJMDC.51-1672675373

Web Style

Asiri SY, Alqarni RT, Alkhaldi NK, Alharbi NN, Alkhayal SM, Alghamdi GM, Alghamdi WK, Al-taleb MA, Aldrees MA. Monogenic forms of childhood obesity: a review. https://www.ijmdc.com/?mno=135946 [Access: April 22, 2025]. doi:10.24911/IJMDC.51-1672675373

AMA (American Medical Association) Style

Asiri SY, Alqarni RT, Alkhaldi NK, Alharbi NN, Alkhayal SM, Alghamdi GM, Alghamdi WK, Al-taleb MA, Aldrees MA. Monogenic forms of childhood obesity: a review. IJMDC. 2023; 7(4): 716-721. doi:10.24911/IJMDC.51-1672675373

Vancouver/ICMJE Style

Asiri SY, Alqarni RT, Alkhaldi NK, Alharbi NN, Alkhayal SM, Alghamdi GM, Alghamdi WK, Al-taleb MA, Aldrees MA. Monogenic forms of childhood obesity: a review. IJMDC. (2023), [cited April 22, 2025]; 7(4): 716-721. doi:10.24911/IJMDC.51-1672675373

Harvard Style

Asiri, S. Y., Alqarni, . R. T., Alkhaldi, . N. K., Alharbi, . N. N., Alkhayal, . S. M., Alghamdi, . G. M., Alghamdi, . W. K., Al-taleb, . M. A. & Aldrees, . M. A. (2023) Monogenic forms of childhood obesity: a review. IJMDC, 7 (4), 716-721. doi:10.24911/IJMDC.51-1672675373

Turabian Style

Asiri, Sultan Yahya, Razan Thamer Alqarni, Njoud Khaled Alkhaldi, Njoud Naif Alharbi, Shaden Mohammed Alkhayal, Ghadeer Mohammed Alghamdi, Waad Khalid Alghamdi, Maram Abdullah Al-taleb, and Meshael Abdulmohsin Aldrees. 2023. Monogenic forms of childhood obesity: a review. International Journal of Medicine in Developing Countries, 7 (4), 716-721. doi:10.24911/IJMDC.51-1672675373

Chicago Style

Asiri, Sultan Yahya, Razan Thamer Alqarni, Njoud Khaled Alkhaldi, Njoud Naif Alharbi, Shaden Mohammed Alkhayal, Ghadeer Mohammed Alghamdi, Waad Khalid Alghamdi, Maram Abdullah Al-taleb, and Meshael Abdulmohsin Aldrees. "Monogenic forms of childhood obesity: a review." International Journal of Medicine in Developing Countries 7 (2023), 716-721. doi:10.24911/IJMDC.51-1672675373

MLA (The Modern Language Association) Style

Asiri, Sultan Yahya, Razan Thamer Alqarni, Njoud Khaled Alkhaldi, Njoud Naif Alharbi, Shaden Mohammed Alkhayal, Ghadeer Mohammed Alghamdi, Waad Khalid Alghamdi, Maram Abdullah Al-taleb, and Meshael Abdulmohsin Aldrees. "Monogenic forms of childhood obesity: a review." International Journal of Medicine in Developing Countries 7.4 (2023), 716-721. Print. doi:10.24911/IJMDC.51-1672675373

APA (American Psychological Association) Style

Asiri, S. Y., Alqarni, . R. T., Alkhaldi, . N. K., Alharbi, . N. N., Alkhayal, . S. M., Alghamdi, . G. M., Alghamdi, . W. K., Al-taleb, . M. A. & Aldrees, . M. A. (2023) Monogenic forms of childhood obesity: a review. International Journal of Medicine in Developing Countries, 7 (4), 716-721. doi:10.24911/IJMDC.51-1672675373

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