E-ISSN 1658-7820
 

Review Article

Online Publishing Date:
28 / 12 / 2022

 


Comorbidities in sickle cell disease patients with obstructive sleep apnea: a systematic review and meta-analysis

Samah Mohamed Elmubarak Hassan, Saleh Abdullah S. Almoallem, Abdullah Mohammad G. Alruwaili, Ahmad Saleh A. Alrwaili, Saif Daham Zaid Alshalan, Saud Abdulaziz A. Alqader, Jamal Mohammed Ali Alhawiti, Ali Nuwaysir S. Alruwaili.


Abstract
Aim: Sickle cell disease (SCD) is a hematologic multisystem disorder. Despite rapid growth in the therapeutic modalities for SCD, it is still considered a life-threatening disorder with high morbidity and mortality rates. This study aims at assessing the prevalence of the comorbidities in patients with SCD with obstructive sleep apnea (OSA).
Methods: A computerized search was conducted through six databases. We included all papers that discussed the prevalence of neurological comorbidities in patients with SCD and OSA, whether alone or compared to patients with SCD and without OSA or any comparator. We calculated odds ratios (ORs) with corresponding 95% confidence intervals (95% CI) for stroke rates.
Results: Finally, we included six papers for this systematic review. There was a significant increase in stroke odds among the OSA group compared to the non-OSA one (OR = 1.84; 95% CI = 1.18-2.87; p-value = 0.024), with no significant heterogeneity among the included studies (I2 = 36%; p-value = 0.194). Seizure rates showed a significant increase in those with OSA compared to those without it (2.9% vs.1.7%; p-value < 0.001). The TIA and silent cerebral infarct rates were comparable among OSA and non-OSA groups.
Conclusion: OSA imposes a risk of neurological comorbidities among SCD patients.

Key words: Comorbidities , sickle cell disease, obstructive sleep apnea


 
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How to Cite this Article
Pubmed Style

Hassan SME, Almoallem SAS, Alruwaili AMG, Alrwaili ASA, Alshalan SDZ, Alqader SAA, Alhawiti JMA, Alruwaili ANS. Comorbidities in sickle cell disease patients with obstructive sleep apnea: a systematic review and meta-analysis. IJMDC. 2023; 7(4): 695-700. doi:10.24911/IJMDC.51-1669378064


Web Style

Hassan SME, Almoallem SAS, Alruwaili AMG, Alrwaili ASA, Alshalan SDZ, Alqader SAA, Alhawiti JMA, Alruwaili ANS. Comorbidities in sickle cell disease patients with obstructive sleep apnea: a systematic review and meta-analysis. https://www.ijmdc.com/?mno=132640 [Access: February 27, 2024]. doi:10.24911/IJMDC.51-1669378064


AMA (American Medical Association) Style

Hassan SME, Almoallem SAS, Alruwaili AMG, Alrwaili ASA, Alshalan SDZ, Alqader SAA, Alhawiti JMA, Alruwaili ANS. Comorbidities in sickle cell disease patients with obstructive sleep apnea: a systematic review and meta-analysis. IJMDC. 2023; 7(4): 695-700. doi:10.24911/IJMDC.51-1669378064



Vancouver/ICMJE Style

Hassan SME, Almoallem SAS, Alruwaili AMG, Alrwaili ASA, Alshalan SDZ, Alqader SAA, Alhawiti JMA, Alruwaili ANS. Comorbidities in sickle cell disease patients with obstructive sleep apnea: a systematic review and meta-analysis. IJMDC. (2023), [cited February 27, 2024]; 7(4): 695-700. doi:10.24911/IJMDC.51-1669378064



Harvard Style

Hassan, S. M. E., Almoallem, . S. A. S., Alruwaili, . A. M. G., Alrwaili, . A. S. A., Alshalan, . S. D. Z., Alqader, . S. A. A., Alhawiti, . J. M. A. & Alruwaili, . A. N. S. (2023) Comorbidities in sickle cell disease patients with obstructive sleep apnea: a systematic review and meta-analysis. IJMDC, 7 (4), 695-700. doi:10.24911/IJMDC.51-1669378064



Turabian Style

Hassan, Samah Mohamed Elmubarak, Saleh Abdullah S. Almoallem, Abdullah Mohammad G. Alruwaili, Ahmad Saleh A. Alrwaili, Saif Daham Zaid Alshalan, Saud Abdulaziz A. Alqader, Jamal Mohammed Ali Alhawiti, and Ali Nuwaysir S. Alruwaili. 2023. Comorbidities in sickle cell disease patients with obstructive sleep apnea: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 7 (4), 695-700. doi:10.24911/IJMDC.51-1669378064



Chicago Style

Hassan, Samah Mohamed Elmubarak, Saleh Abdullah S. Almoallem, Abdullah Mohammad G. Alruwaili, Ahmad Saleh A. Alrwaili, Saif Daham Zaid Alshalan, Saud Abdulaziz A. Alqader, Jamal Mohammed Ali Alhawiti, and Ali Nuwaysir S. Alruwaili. "Comorbidities in sickle cell disease patients with obstructive sleep apnea: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 7 (2023), 695-700. doi:10.24911/IJMDC.51-1669378064



MLA (The Modern Language Association) Style

Hassan, Samah Mohamed Elmubarak, Saleh Abdullah S. Almoallem, Abdullah Mohammad G. Alruwaili, Ahmad Saleh A. Alrwaili, Saif Daham Zaid Alshalan, Saud Abdulaziz A. Alqader, Jamal Mohammed Ali Alhawiti, and Ali Nuwaysir S. Alruwaili. "Comorbidities in sickle cell disease patients with obstructive sleep apnea: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 7.4 (2023), 695-700. Print. doi:10.24911/IJMDC.51-1669378064



APA (American Psychological Association) Style

Hassan, S. M. E., Almoallem, . S. A. S., Alruwaili, . A. M. G., Alrwaili, . A. S. A., Alshalan, . S. D. Z., Alqader, . S. A. A., Alhawiti, . J. M. A. & Alruwaili, . A. N. S. (2023) Comorbidities in sickle cell disease patients with obstructive sleep apnea: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 7 (4), 695-700. doi:10.24911/IJMDC.51-1669378064





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