Review Article
IJMDC. 2023; 7(4): 695-700
Comorbidities in sickle cell disease patients with obstructive sleep apnea: a systematic review and meta-analysis
Authors: Samah Mohamed Elmubarak Hassan, Saleh Abdullah S. Almoallem, Abdullah Mohammad G. Alruwaili, Ahmad Saleh A. Alrwaili, Saif Daham Zaid Alshalan, Saud Abdulaziz A. Alqader, Jamal Mohammed Ali Alhawiti, Ali Nuwaysir S. Alruwaili.
ABSTRACT
Aim: Sickle cell disease (SCD) is a hematologic multisystem disorder. Despite rapid growth in the therapeutic modalities for SCD, it is still considered a life-threatening disorder with high morbidity and mortality rates. This study aims at assessing the prevalence of the comorbidities in patients with SCD with obstructive sleep apnea (OSA). Methods: A computerized search was conducted through six databases. We included all papers that discussed the prevalence of neurological comorbidities in patients with SCD and OSA, whether alone or compared to patients with SCD and without OSA or any comparator. We calculated odds ratios (ORs) with corresponding 95% confidence intervals (95% CI) for stroke rates. Results: Finally, we included six papers for this systematic review. There was a significant increase in stroke odds among the OSA group compared to the non-OSA one (OR = 1.84; 95% CI = 1.18-2.87; p-value = 0.024), with no significant heterogeneity among the included studies (I2 = 36%; p-value = 0.194). Seizure rates showed a significant increase in those with OSA compared to those without it (2.9% vs.1.7%; p-value < 0.001). The TIA and silent cerebral infarct rates were comparable among OSA and non-OSA groups. Conclusion: OSA imposes a risk of neurological comorbidities among SCD patients.
Keywords:
Comorbidities , sickle cell disease, obstructive sleep apnea
Authors
Samah Mohamed Elmubarak Hassan
Family Medicine, King Khaled Hospital, Tabuk, Saudi Arabia
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Saleh Abdullah S Almoallem
Family Medicine, King Khaled Hospital, Tabuk, Saudi Arabia
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Abdullah Mohammad G Alruwaili
Family Medicine, Jouf University, Al Jouf, Saudi Arabia
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Ahmad Saleh A Alrwaili
Family Medicine, King Abdulaziz Specialized Hospital, Sakaka, Saudi Arabia
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Saif Daham Zaid Alshalan
Family Medicine, Turaif General Hospital, Northern Border Region, Saudi Arabia
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Saud Abdulaziz A Alqader
Family Medicine, Iradh Hospital, Skaka Aljouf, Saudi Arabia
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Jamal Mohammed Ali Alhawiti
Family Medicine, Jouf University, Al Jouf, Saudi Arabia
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Ali Nuwaysir S Alruwaili
Intern, Family Medicine, Jouf University, Sakaka, Saudi Arabia.
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Correspondence to:
. Family Medicine, King Khaled Hospital, Tabuk, Saudi Arabia.; s2le7@hotmail.com
Publication history
Received 25 Nov 2022
Accepted 11 Dec 2022
Published online 28 Dec 2022
Published in print 15 Jan 2023
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Export to EndNote Export to refManPubmed Style
Hassan SME, Almoallem SAS, Alruwaili AMG, Alrwaili ASA, Alshalan SDZ, Alqader SAA, Alhawiti JMA, Alruwaili ANS. Comorbidities in sickle cell disease patients with obstructive sleep apnea: a systematic review and meta-analysis. IJMDC. 2023; 7(4): 695-700. doi:10.24911/IJMDC.51-1669378064
Web Style
Hassan SME, Almoallem SAS, Alruwaili AMG, Alrwaili ASA, Alshalan SDZ, Alqader SAA, Alhawiti JMA, Alruwaili ANS. Comorbidities in sickle cell disease patients with obstructive sleep apnea: a systematic review and meta-analysis. https://www.ijmdc.com/?mno=132640 [Access: March 22, 2023]. doi:10.24911/IJMDC.51-1669378064
AMA (American Medical Association) Style
Hassan SME, Almoallem SAS, Alruwaili AMG, Alrwaili ASA, Alshalan SDZ, Alqader SAA, Alhawiti JMA, Alruwaili ANS. Comorbidities in sickle cell disease patients with obstructive sleep apnea: a systematic review and meta-analysis. IJMDC. 2023; 7(4): 695-700. doi:10.24911/IJMDC.51-1669378064
Vancouver/ICMJE Style
Hassan SME, Almoallem SAS, Alruwaili AMG, Alrwaili ASA, Alshalan SDZ, Alqader SAA, Alhawiti JMA, Alruwaili ANS. Comorbidities in sickle cell disease patients with obstructive sleep apnea: a systematic review and meta-analysis. IJMDC. (2023), [cited March 22, 2023]; 7(4): 695-700. doi:10.24911/IJMDC.51-1669378064
Harvard Style
Hassan, S. M. E., Almoallem, . S. A. S., Alruwaili, . A. M. G., Alrwaili, . A. S. A., Alshalan, . S. D. Z., Alqader, . S. A. A., Alhawiti, . J. M. A. & Alruwaili, . A. N. S. (2023) Comorbidities in sickle cell disease patients with obstructive sleep apnea: a systematic review and meta-analysis. IJMDC, 7 (4), 695-700. doi:10.24911/IJMDC.51-1669378064
Turabian Style
Hassan, Samah Mohamed Elmubarak, Saleh Abdullah S. Almoallem, Abdullah Mohammad G. Alruwaili, Ahmad Saleh A. Alrwaili, Saif Daham Zaid Alshalan, Saud Abdulaziz A. Alqader, Jamal Mohammed Ali Alhawiti, and Ali Nuwaysir S. Alruwaili. 2023. Comorbidities in sickle cell disease patients with obstructive sleep apnea: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 7 (4), 695-700. doi:10.24911/IJMDC.51-1669378064
Chicago Style
Hassan, Samah Mohamed Elmubarak, Saleh Abdullah S. Almoallem, Abdullah Mohammad G. Alruwaili, Ahmad Saleh A. Alrwaili, Saif Daham Zaid Alshalan, Saud Abdulaziz A. Alqader, Jamal Mohammed Ali Alhawiti, and Ali Nuwaysir S. Alruwaili. "Comorbidities in sickle cell disease patients with obstructive sleep apnea: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 7 (2023), 695-700. doi:10.24911/IJMDC.51-1669378064
MLA (The Modern Language Association) Style
Hassan, Samah Mohamed Elmubarak, Saleh Abdullah S. Almoallem, Abdullah Mohammad G. Alruwaili, Ahmad Saleh A. Alrwaili, Saif Daham Zaid Alshalan, Saud Abdulaziz A. Alqader, Jamal Mohammed Ali Alhawiti, and Ali Nuwaysir S. Alruwaili. "Comorbidities in sickle cell disease patients with obstructive sleep apnea: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 7.4 (2023), 695-700. Print. doi:10.24911/IJMDC.51-1669378064
APA (American Psychological Association) Style
Hassan, S. M. E., Almoallem, . S. A. S., Alruwaili, . A. M. G., Alrwaili, . A. S. A., Alshalan, . S. D. Z., Alqader, . S. A. A., Alhawiti, . J. M. A. & Alruwaili, . A. N. S. (2023) Comorbidities in sickle cell disease patients with obstructive sleep apnea: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 7 (4), 695-700. doi:10.24911/IJMDC.51-1669378064
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