E-ISSN 1658-7820
 

Review Article

Online Publishing Date:
12 / 01 / 2023

 


β-blocker dose, heart rate reduction, and death in patients with heart f ailure: a systematic review

Maram Alomari, Abdullah Alyahia, Nuha Al Otaibi, Naif Al Ruais, Norah Alzayed, Dhaifallah Alotaibi.


Abstract
Background: In individuals with systolic chronic Heart failure (HF), β-blockers enhance cardiac function and increase survival. The precise processes driving these advantages are unclear, though. It is uncertain if there is a direct link between clinical results with these medications and heart rate (HR) decrease. According to recommendations, β-blockers should be administered to individuals with HF at effective dosages in clinical studies. It is unknown if the advantages of β-blockade are dose-related, even though the disadvantages are.
Aim: To investigate the survival benefits of β-blockade in HF and its association with the level of HR reduction or the β-blocker dose.
Methods: This is an updated systematic review of studies discussing the survival benefits of β-blockade in HF and its association with the level of HR reduction or the β-blocker dose between 2020 and 2022. The PubMed and Google Scholar databases were used to explore studies regarding our subject. The keywords included “β-blocker Dose, Heart Rate Reduction, Death, Patients, and Heart Failure,” and were used in various combinations. The inclusion criteria were original studies that reported the survival benefits of β-blockade in HF and its association with the level of HR reduction or the β-blocker dose and full-text articles.
Results: Though 240 articles were obtained, only 8 of them met the inclusion criteria. The studies included more than 120,348 patients: 4 prospective studies, 1 case series, 1 multicenter, a randomized clinical trial, and 2 observational cohort studies.
Conclusion: Oral β-blocker therapy was independently associated with a lower risk of poor in-hospital outcomes in sore throat speech therapy (ST)-elevation myocardial infarction patients with Killip class II or III HF. In individuals with chronic or acute coronary syndrome, an HR of 70 bpm was related to poorer clinical indicators and prognosis. β-blocker therapy was independently associated with a lower risk of all-cause death. In HF patients with reduced ejection fraction with advanced chronic kidney disease, using β-blockers was linked to decreased morbidity and death rates. Moreover, HF patients who receive medical treatment with βb can reverse exercise oscillatory ventilation.

Key words: β-blocker dose, heart rate reduction, death, patients, and heart failure.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Maram Alomari
Articles by Abdullah Alyahia
Articles by Nuha Al Otaibi
Articles by Naif Al Ruais
Articles by Norah Alzayed
Articles by Dhaifallah Alotaibi
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Alomari M, Alyahia A, Otaibi NA, Ruais NA, Alzayed N, Alotaibi D. β-blocker dose, heart rate reduction, and death in patients with heart f ailure: a systematic review. IJMDC. 2023; 7(4): 687-694. doi:10.24911/IJMDC.51-1667765600


Web Style

Alomari M, Alyahia A, Otaibi NA, Ruais NA, Alzayed N, Alotaibi D. β-blocker dose, heart rate reduction, and death in patients with heart f ailure: a systematic review. https://www.ijmdc.com/?mno=127902 [Access: July 14, 2024]. doi:10.24911/IJMDC.51-1667765600


AMA (American Medical Association) Style

Alomari M, Alyahia A, Otaibi NA, Ruais NA, Alzayed N, Alotaibi D. β-blocker dose, heart rate reduction, and death in patients with heart f ailure: a systematic review. IJMDC. 2023; 7(4): 687-694. doi:10.24911/IJMDC.51-1667765600



Vancouver/ICMJE Style

Alomari M, Alyahia A, Otaibi NA, Ruais NA, Alzayed N, Alotaibi D. β-blocker dose, heart rate reduction, and death in patients with heart f ailure: a systematic review. IJMDC. (2023), [cited July 14, 2024]; 7(4): 687-694. doi:10.24911/IJMDC.51-1667765600



Harvard Style

Alomari, M., Alyahia, . A., Otaibi, . N. A., Ruais, . N. A., Alzayed, . N. & Alotaibi, . D. (2023) β-blocker dose, heart rate reduction, and death in patients with heart f ailure: a systematic review. IJMDC, 7 (4), 687-694. doi:10.24911/IJMDC.51-1667765600



Turabian Style

Alomari, Maram, Abdullah Alyahia, Nuha Al Otaibi, Naif Al Ruais, Norah Alzayed, and Dhaifallah Alotaibi. 2023. β-blocker dose, heart rate reduction, and death in patients with heart f ailure: a systematic review. International Journal of Medicine in Developing Countries, 7 (4), 687-694. doi:10.24911/IJMDC.51-1667765600



Chicago Style

Alomari, Maram, Abdullah Alyahia, Nuha Al Otaibi, Naif Al Ruais, Norah Alzayed, and Dhaifallah Alotaibi. "β-blocker dose, heart rate reduction, and death in patients with heart f ailure: a systematic review." International Journal of Medicine in Developing Countries 7 (2023), 687-694. doi:10.24911/IJMDC.51-1667765600



MLA (The Modern Language Association) Style

Alomari, Maram, Abdullah Alyahia, Nuha Al Otaibi, Naif Al Ruais, Norah Alzayed, and Dhaifallah Alotaibi. "β-blocker dose, heart rate reduction, and death in patients with heart f ailure: a systematic review." International Journal of Medicine in Developing Countries 7.4 (2023), 687-694. Print. doi:10.24911/IJMDC.51-1667765600



APA (American Psychological Association) Style

Alomari, M., Alyahia, . A., Otaibi, . N. A., Ruais, . N. A., Alzayed, . N. & Alotaibi, . D. (2023) β-blocker dose, heart rate reduction, and death in patients with heart f ailure: a systematic review. International Journal of Medicine in Developing Countries, 7 (4), 687-694. doi:10.24911/IJMDC.51-1667765600





Most Viewed Articles
Most Accessed Articles

  • Marginal adaptation of fixed prosthodontics
    Shahad Mohammed Halawani, Sahar Amer Al-Harbi
    IJMDC. 2017; 1(2): 78-84
    » Abstract » doi: 10.24911/IJMDC.1.2.7

  • Parasites in central nervous system
    Amal Ahmed Mohamed, Asmaa Mohamed Mansour
    IJMDC. 2017; 1(2): 72-77
    » Abstract » doi: 10.24911/IJMDC.1.2.6

  • Non-diabetic retinopathy: a case report
    Hassan F. Alkwikbi, Nabil Mamon Abdelfattah, Haithem Mamon Abdelfattah
    IJMDC. 2017; 1(1): 33-37
    » Abstract » doi: 10.24911/IJMDC.1.1.6

  • Vitamin D deficiency among high school female students in Riyadh
    Sahar Mohsen Aldhafeeri, Fatemah Ibraheem Alrawaji, Abrar Mubarak Algharbi, Alanoud Abdullah Alhessan, Ayat Sami Qabaja, Ghaleah Abdulaziz Alnassar, Ghaliah Ofayn Alsulami, Mashael Belal Alrubaian, Norah Abdulaziz Alhatim, Salehah Salih Alotaibi, Zahra Ali Alkhamees
    IJMDC. 2017; 1(1): 18-23
    » Abstract » doi: 10.24911/IJMDC.1.1.4

  • Prognosis of chronic complications of diabetes mellitus (DM) after multiple events of diabetic ketoacidosis (DKA)
    Baraa Faiez Rajab, Anwar Essa Alamrim, Ali Essa Alamri
    IJMDC. 2019; 3(5): 474-479
    » Abstract » doi: 10.24911/IJMDC.51-1546551993

  • Most Downloaded
    Top Downloaded Articles

  • Anti-IL-17 markedly inhibited the in vitro granuloma induced by Schistosoma mansoni soluble egg antigen.
    Asmaa Ezz, Irene S. Gmail, Fatma Elzahraa H. Salem, Rabab Salama, Soad Nady
    IJMDC. 2018; 2(January 2018): 38-46
    » Abstract » doi: 10.24911/IJMDC.2.1.7

  • Vitamin D deficiency among high school female students in Riyadh
    Sahar Mohsen Aldhafeeri, Fatemah Ibraheem Alrawaji, Abrar Mubarak Algharbi, Alanoud Abdullah Alhessan, Ayat Sami Qabaja, Ghaleah Abdulaziz Alnassar, Ghaliah Ofayn Alsulami, Mashael Belal Alrubaian, Norah Abdulaziz Alhatim, Salehah Salih Alotaibi, Zahra Ali Alkhamees
    IJMDC. 2017; 1(1): 18-23
    » Abstract » doi: 10.24911/IJMDC.1.1.4

  • Antibiotic Resistance Crisis
    Nuha Saad Mobarki, Buthaina Abdullah Almerabi, Ahmad Hattan Hattan
    IJMDC. 2019; 3(6): 561-564
    » Abstract » doi: 10.24911/IJMDC.51-1549060699

  • The knowledge of mothers about children malnutrition and associated factors
    Anas Abdulrahman Aljohani, Mujahid Abdulrahman Aljohani
    IJMDC. 2020; 4(1): 7-11
    » Abstract » doi: 10.24911/IJMDC.51-1541620358

  • Knowledge and attitude of caregivers of cerebral palsy children in Riyadh city
    Abdulaziz Alruwaished, Baleegh Ali, Lubna Abdullah Alhowaimil , Abaraa adullah Alhowaimil, Najd Abdullah Alhowaimil, Aminah Alessa
    IJMDC. 2020; 4(1): 12-17
    » Abstract » doi: 10.24911/IJMDC.51-1547833051

  • Most Cited Articles
    Most Cited Articles

  • Antibiotic Resistance Crisis
    Nuha Saad Mobarki, Buthaina Abdullah Almerabi, Ahmad Hattan Hattan
    IJMDC. 2019; 3(6): 561-564
    » Abstract » doi: 10.24911/IJMDC.51-1549060699
    Cited : 34 times [Click to see citing articles]

  • Prevalence of depression, anxiety and stress among diabetes mellitus patients in Arar, Northern Saudi Arabia
    AMohammed Elamin Mukrim, Nujud Muteb D. Alshammari, Wurud Muteb D. Alshammari, Maali Subhi T. Alshammari, Yousef Nasif R. Alshammari, Abdulaziz Sael M. Alshammari, Maisa Hamad F. Alanazi, Abdulelah Abdulrhman F. Alzammam, Muharib Mana M. Alshammari, Slwa Khaled Abu Asyah, Aseel Jamal Alzuhayri, Mushref Saeid Alshammari
    IJMDC. 2019; 3(3): 229-233
    » Abstract » doi: 10.24911/IJMDC.51-1542576396
    Cited : 8 times [Click to see citing articles]

  • Knowledge, attitude, and practice of breast self-examination toward breast cancer among female students at King Saud University in Riyadh, Saudi Arabia
    Abdullah Nasser Alomair, Dania Ghazi Felemban, Mohannad Sami Felemban, Jameel Abdullah Awadain, Ammar Saud Altowairqi, Nawaf Fawzan Alfawzan, Fatimah Mohammed Almazayen, Abdulrahman Jalwi Korkoman, Nawaf Saad Alrusayyis
    IJMDC. 2020; 4(2): 429-434
    » Abstract » doi: 10.24911/IJMDC.51-1576668182
    Cited : 8 times [Click to see citing articles]

  • Population awareness about rheumatoid arthritis in Jazan region, Saudi Arabia
    Ahmad Ali Hazzazi, Mohssen Hassen Ageeli, Ahmed Ali Muyidi, Abdulaziz Mohammad Abulgasim, Abdullah Ahmad Yateemi, Nabil Alhakami
    IJMDC. 2020; 4(3): 668-675
    » Abstract » doi: 10.24911/IJMDC.51-1576010943
    Cited : 4 times [Click to see citing articles]

  • Prevalence and factors associated with depression among health care workers in National Guard Hospital in Riyadh, KSA
    Noor Mohammad AlFahhad
    IJMDC. 2018; 2(September 2018): 92-96
    » Abstract » doi: 10.24911/IJMDC.51-1526306040
    Cited : 4 times [Click to see citing articles]