Original Article

IJMDC. 2021; 5(1): 1-5

Vanillylacetone modulates acetaminophen induced hepatotoxicity in rats

Authors: Fadwa Fahad Alkhuraisi, Abdullah Mohammed Qahl, Sulaiman Abdulaziz Alderaibi, Abdulatif Arif Ibrahim Hadadi, Yasir Mohammed Hanbashi, Naif Ali Arishi, Nasser Ali Mansour Hanbashi.

ABSTRACT

Background: Acetaminophen (APAP) overdose is the most common type of drug-induced liver toxicity in humans. In this study, we investigated the protective mechanism of Vanillylacetone, which is the active ingredient of Ginger against APAP. Methodology: Rats were classified into four groups, and each was having six rats. Group-I was controlling, and the vehicle was given orally. Group II was toxic, and APAP was administered 2 g/kg p.o for 7 days. Group III was treating Vanillylacetone 60 mg/kg body weight given every day p.o. for 7 days. Group IV was parse and only given Vanillylacetone (60 mg/kg body weight) for 7 days. On day 8, the blood was collected, and rats were sacrificed immediately. Results: The levels of hepatic enzymes were monitored, and the result was significantly increased in Group-II (Toxic) as compared to Group-I (control). The level of these enzymes was decreased in Group-III (Toxic drug), and no changes in serum marker were observed in Group-IV compared to Group-I. The oxidative stress parameter like left posterior oblique (LPO) was also measured, and results indicated a significant increment in the content of thiobarbituric acid reactive substances (TBARS) in Group-II compared to Group-I. At the same time, the glutathione was reduced in Group-II as compared to Group-I. Still, after the treatment with Vanillylacetone, it was significantly recovered in Group-III as compared to Group-II. Thus, the outcome provides a clear picture of the protective mechanism of Vanillylacetone against APAP-induced hepatotoxicity. Conclusion: This result showed that the Vanillylacetone effectively suppresses the harmful effect of APAP on the liver due to its antioxidant properties, which had a major role in preventing the induction of hepatotoxicity.

Keywords:
Acetaminophen, hepatotoxicity, rats, Vanillylacetone


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Vanillylacetone modulates acetaminophen induced hepatotoxicity in rats


Authors
Fadwa Fahad Alkhuraisi
Prince Sultan Cardiac Center, Riyadh, Kingdom of Saudi Arabia
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Abdullah Mohammed Qahl
Jazan University Hospital, Jizan, Kingdom of Saudi Arabia
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Sulaiman Abdulaziz Alderaibi
Qassim Armed Forces Hospital, Qassim, Kingdom of Saudi Arabia
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Abdulatif Arif Ibrahim Hadadi
King Fahad Specialist Hospital, Dammam, Kingdom of Saudi Arabia
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Yasir Mohammed Hanbashi
Qassim Armed Forces Hospital, Qassim, Kingdom of Saudi Arabia
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Naif Ali Arishi
Qassim Armed Forces Hospital, Qassim, Kingdom of Saudi Arabia
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Nasser Ali Mansour Hanbashi
Mental Hospital Qassim, Ministry of Health, Qassim, Kingdom of Saudi Arabia
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Correspondence to:
. Naif Ali Arishi, Qassim Armed Forces Hospital, Qassim, Kingdom of Saudi Arabia.; naifaliarishi@gmail.com

Publication history
Received 17 Aug 2020
Accepted 04 Dec 2020
Published online 30 Dec 2020
Published in print 11 Jan 2021

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Pubmed Style

Alkhuraisi FF, Qahl AM, Alderaibi SA, Hadadi AAI, Hanbashi YM, Arishi NA, Hanbashi NAM. Vanillylacetone modulates acetaminophen induced hepatotoxicity in rats. IJMDC. 2021; 5(1): 1-5. doi:10.24911/IJMDC.51-1597568852


Web Style

Alkhuraisi FF, Qahl AM, Alderaibi SA, Hadadi AAI, Hanbashi YM, Arishi NA, Hanbashi NAM. Vanillylacetone modulates acetaminophen induced hepatotoxicity in rats. http://www.ijmdc.com/?mno=125804 [Access: March 07, 2021]. doi:10.24911/IJMDC.51-1597568852


AMA (American Medical Association) Style

Alkhuraisi FF, Qahl AM, Alderaibi SA, Hadadi AAI, Hanbashi YM, Arishi NA, Hanbashi NAM. Vanillylacetone modulates acetaminophen induced hepatotoxicity in rats. IJMDC. 2021; 5(1): 1-5. doi:10.24911/IJMDC.51-1597568852


Vancouver/ICMJE Style

Alkhuraisi FF, Qahl AM, Alderaibi SA, Hadadi AAI, Hanbashi YM, Arishi NA, Hanbashi NAM. Vanillylacetone modulates acetaminophen induced hepatotoxicity in rats. IJMDC. (2021), [cited March 07, 2021]; 5(1): 1-5. doi:10.24911/IJMDC.51-1597568852


Harvard Style

Alkhuraisi, F. F., Qahl, . A. M., Alderaibi, . S. A., Hadadi, . A. A. I., Hanbashi, . Y. M., Arishi, . N. A. & Hanbashi, . N. A. M. (2021) Vanillylacetone modulates acetaminophen induced hepatotoxicity in rats. IJMDC, 5 (1), 1-5. doi:10.24911/IJMDC.51-1597568852


Turabian Style

Alkhuraisi, Fadwa Fahad, Abdullah Mohammed Qahl, Sulaiman Abdulaziz Alderaibi, Abdulatif Arif Ibrahim Hadadi, Yasir Mohammed Hanbashi, Naif Ali Arishi, and Nasser Ali Mansour Hanbashi. 2021. Vanillylacetone modulates acetaminophen induced hepatotoxicity in rats. International Journal of Medicine in Developing Countries, 5 (1), 1-5. doi:10.24911/IJMDC.51-1597568852


Chicago Style

Alkhuraisi, Fadwa Fahad, Abdullah Mohammed Qahl, Sulaiman Abdulaziz Alderaibi, Abdulatif Arif Ibrahim Hadadi, Yasir Mohammed Hanbashi, Naif Ali Arishi, and Nasser Ali Mansour Hanbashi. "Vanillylacetone modulates acetaminophen induced hepatotoxicity in rats." International Journal of Medicine in Developing Countries 5 (2021), 1-5. doi:10.24911/IJMDC.51-1597568852


MLA (The Modern Language Association) Style

Alkhuraisi, Fadwa Fahad, Abdullah Mohammed Qahl, Sulaiman Abdulaziz Alderaibi, Abdulatif Arif Ibrahim Hadadi, Yasir Mohammed Hanbashi, Naif Ali Arishi, and Nasser Ali Mansour Hanbashi. "Vanillylacetone modulates acetaminophen induced hepatotoxicity in rats." International Journal of Medicine in Developing Countries 5.1 (2021), 1-5. Print. doi:10.24911/IJMDC.51-1597568852


APA (American Psychological Association) Style

Alkhuraisi, F. F., Qahl, . A. M., Alderaibi, . S. A., Hadadi, . A. A. I., Hanbashi, . Y. M., Arishi, . N. A. & Hanbashi, . N. A. M. (2021) Vanillylacetone modulates acetaminophen induced hepatotoxicity in rats. International Journal of Medicine in Developing Countries, 5 (1), 1-5. doi:10.24911/IJMDC.51-1597568852


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