Original Article

IJMDC. 2022; 6(7): 900-908

Acquired thrombotic thrombocytopenic purpura landscaping in Gulf countries: a study protocol

Authors: Magdy Rabea, Mina Nagib, Zahir Chouikrat.

ABSTRACT

Background: Thrombotic thrombocytopenic purpura (TTP) is a very rare, life-threatening disorder that results in blood clots in the small blood vessels leading to its occlusion with consequent reduction of the blood flow to vital organs, including the heart, brain, and kidney. TTP prevalence is increasing worldwide. Data related to disease nature and local burden on the healthcare system in Gulf countries are not available. The main objective of this study protocol is to explore and identify the local burden (clinical and healthcare utilization) of acquired thrombotic thrombocytopenic purpura (aTTP) and understand the aTTP management pattern in the Greater Gulf region. Methods: This multi-national, observational, retrospective study will extract data of aTTP patients from existing medical records. Fifty eligible aTTP patients are planned to be included from five countries in the Arabian Gulf region. Each patient’s record (either hard or electronic) will be assessed for data availability and quality. The primary outcomes of this study will be to assess the time to reach platelet normalization, clinical remission rate, mortality rate, rate of recurrence, and refractoriness to treatment. Results: This protocol was reviewed and approved by the Institutional Review Board of the included centers and funded by Sanofi Genzyme, Gulf region. Our sample size calculation provided a total sample ranging between 40 to 60 patients to be included for data extraction. With this state of data scarcity and heavy healthcare resources utilization, courtiers of the Arabian Gulf region are facing local problems due to the significant disease burden on aTTP patients. The patient’s journey in the Gulf region is not previously described in the literature. Therefore, to understand the disease’s nature and local burden in this part of the world, we will collect data related to the patient’s journey and different clinical practices. Conclusion: These data will help us discover our healthcare system’s weak points, address unmet medical needs, and implement healthcare resources in more practical and efficient methods.

Keywords:
Thrombotic thrombocytopenic purpura, TTP, aTTP, plasma exchange, gulf.


';
Acquired thrombotic thrombocytopenic purpura landscaping in Gulf countries: a study protocol


Authors
Magdy Rabea
Sanofi Genzyme, Department of Medical Affairs, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles

Mina Nagib
Sanofi-Genzyme, Dubai, United Arab Emirates
PubMed articlesGoogle scholar articles

Zahir Chouikrat
Sanofi-Genzyme, Dubai, United Arab Emirates.
PubMed articlesGoogle scholar articles


Correspondence to:
. Sanofi Genzyme, Department of Medical Affairs, Jeddah, Saudi Arabia.; Magdy.Rabea@sanofi.com

Publication history
Received 17 Nov 2021
Revised 05 Apr 2022
Accepted 25 Apr 2022
Published online 24 May 2022
Published in print 08 Jul 2022

How to cite this article?

Export to EndNote Export to refMan

Pubmed Style

Rabea M, Nagib M, Chouikrat Z. Acquired thrombotic thrombocytopenic purpura landscaping in Gulf countries: a study protocol. IJMDC. 2022; 6(7): 900-908. doi:10.24911/IJMDC.51-1637147458


Web Style

Rabea M, Nagib M, Chouikrat Z. Acquired thrombotic thrombocytopenic purpura landscaping in Gulf countries: a study protocol. https://www.ijmdc.com/?mno=10932 [Access: August 18, 2022]. doi:10.24911/IJMDC.51-1637147458


AMA (American Medical Association) Style

Rabea M, Nagib M, Chouikrat Z. Acquired thrombotic thrombocytopenic purpura landscaping in Gulf countries: a study protocol. IJMDC. 2022; 6(7): 900-908. doi:10.24911/IJMDC.51-1637147458


Vancouver/ICMJE Style

Rabea M, Nagib M, Chouikrat Z. Acquired thrombotic thrombocytopenic purpura landscaping in Gulf countries: a study protocol. IJMDC. (2022), [cited August 18, 2022]; 6(7): 900-908. doi:10.24911/IJMDC.51-1637147458


Harvard Style

Rabea, M., Nagib, . M. & Chouikrat, . Z. (2022) Acquired thrombotic thrombocytopenic purpura landscaping in Gulf countries: a study protocol. IJMDC, 6 (7), 900-908. doi:10.24911/IJMDC.51-1637147458


Turabian Style

Rabea, Magdy, Mina Nagib, and Zahir Chouikrat. 2022. Acquired thrombotic thrombocytopenic purpura landscaping in Gulf countries: a study protocol. International Journal of Medicine in Developing Countries, 6 (7), 900-908. doi:10.24911/IJMDC.51-1637147458


Chicago Style

Rabea, Magdy, Mina Nagib, and Zahir Chouikrat. "Acquired thrombotic thrombocytopenic purpura landscaping in Gulf countries: a study protocol." International Journal of Medicine in Developing Countries 6 (2022), 900-908. doi:10.24911/IJMDC.51-1637147458


MLA (The Modern Language Association) Style

Rabea, Magdy, Mina Nagib, and Zahir Chouikrat. "Acquired thrombotic thrombocytopenic purpura landscaping in Gulf countries: a study protocol." International Journal of Medicine in Developing Countries 6.7 (2022), 900-908. Print. doi:10.24911/IJMDC.51-1637147458


APA (American Psychological Association) Style

Rabea, M., Nagib, . M. & Chouikrat, . Z. (2022) Acquired thrombotic thrombocytopenic purpura landscaping in Gulf countries: a study protocol. International Journal of Medicine in Developing Countries, 6 (7), 900-908. doi:10.24911/IJMDC.51-1637147458


Share this article

Click the icon of the social media platform on which you would like to share this article.

Article Statistics

Request permissions

If you wish to reuse any part or all of this article please contact the copyright holder, contact@ijmdc.com.

Copyright ©2022 Discover STM Publishing. All Rights Reserved.