IJMDC. 2020; 4(6): 1007-1010

Pharmacodynamic interactions of thiazide diuretics

Authors: Naina Mohamed Pakkir Maideen.

ABSTRACT

Thiazide diuretics are used as one of the first-line agents to treat hypertension. However, the treated patients may have to receive multiple medications to treat comorbidities ensuing in drug-induced side effects. The present review was conducted using keywords such as drug interactions, pharmacodynamic drug interactions, thiazide diuretics, hydrochlorothiazide, chlorthalidone, and indapamide. The abovementioned words were searched in databases such as Medline, PubMed, PubMed Central (PMC), Google Scholar, ScienceDirect, Cochrane Library, and reference lists. Thiazides are diuretics, known to interact with drugs such as digoxin, flecainide, and dofetilide pharmacodynamically through thiazide-induced hypokalemia, hyponatremia, and hypovolemia respectively. The pharmacological interaction of thiazide diuretics with drugs such as lithium, angiotensin-converting enzyme inhibitors, non-steroidal anti-inflammatory drugs, antidiabetic, and Vitamin D has been reported. Herbs such as licorice and ginkgo were also studied for their interactivity with thiazides. Doctors and pharmacists are required to be well aware of drug-induced side effects of thiazide. This step is crucial for preventing adverse side effects.

Keywords:
Drug interactions, thiazide diuretics, hydrochlorothiazide, chlorthalidone, indapamide.


View PDF
Pharmacodynamic interactions of thiazide diuretics


Authors
Naina Mohamed Pakkir Maideen
Pharmacologist, Dubai Health Authority, Dubai, United Arab Emirates.
PubMed articlesGoogle scholar articles


Correspondence to:
. Naina Mohamed Pakkir Maideen, Pharmacologist, Dubai Health Authority, Dubai, United Arab Emirates.; nmmaideen@dha.gov.ae

Publication history
Received 29 May 2019
Accepted 14 Jun 2020
Published online 20 Jun 2020
Published in print 25 Jun 2020

How to cite this article?

Export to EndNote Export to refMan

Pubmed Style

Naina Mohamed Pakkir Maideen. Pharmacodynamic interactions of thiazide diuretics. IJMDC. 2020; 4(6): 1007-1010. doi:10.24911/IJMDC.51-1559103046


Web Style

Naina Mohamed Pakkir Maideen. Pharmacodynamic interactions of thiazide diuretics. http://www.ijmdc.com/?mno=51031 [Access: July 14, 2020]. doi:10.24911/IJMDC.51-1559103046


AMA (American Medical Association) Style

Naina Mohamed Pakkir Maideen. Pharmacodynamic interactions of thiazide diuretics. IJMDC. 2020; 4(6): 1007-1010. doi:10.24911/IJMDC.51-1559103046


Vancouver/ICMJE Style

Naina Mohamed Pakkir Maideen. Pharmacodynamic interactions of thiazide diuretics. IJMDC. (2020), [cited July 14, 2020]; 4(6): 1007-1010. doi:10.24911/IJMDC.51-1559103046


Harvard Style

Naina Mohamed Pakkir Maideen (2020) Pharmacodynamic interactions of thiazide diuretics. IJMDC, 4 (6), 1007-1010. doi:10.24911/IJMDC.51-1559103046


Turabian Style

Naina Mohamed Pakkir Maideen. 2020. Pharmacodynamic interactions of thiazide diuretics. International Journal of Medicine in Developing Countries, 4 (6), 1007-1010. doi:10.24911/IJMDC.51-1559103046


Chicago Style

Naina Mohamed Pakkir Maideen. "Pharmacodynamic interactions of thiazide diuretics." International Journal of Medicine in Developing Countries 4 (2020), 1007-1010. doi:10.24911/IJMDC.51-1559103046


MLA (The Modern Language Association) Style

Naina Mohamed Pakkir Maideen. "Pharmacodynamic interactions of thiazide diuretics." International Journal of Medicine in Developing Countries 4.6 (2020), 1007-1010. Print. doi:10.24911/IJMDC.51-1559103046


APA (American Psychological Association) Style

Naina Mohamed Pakkir Maideen (2020) Pharmacodynamic interactions of thiazide diuretics. International Journal of Medicine in Developing Countries, 4 (6), 1007-1010. doi:10.24911/IJMDC.51-1559103046


Share this article

Click the icon of the social media platform on which you would like to share this article.

Article Statistics

Request permissions

If you wish to reuse any part or all of this article please contact the copyright holder, contact@ejmcr.com.

Copyright © 2018 Discover Publishing Group. All Rights Reserved.