IJMDC. 2022; 6(5): 760-767

Potential vaccines and common treatments for COVID-19: a systematic review of randomized controlled trials

Authors: Amjad Saud Alrowili.

ABSTRACT

Coronavirus disease 2019 infection, an emerging infection caused by severe acute respiratory syndrome coronavirus 2, is a respiratory illness attributable to severe respiratory system inflammation. This review aims to evaluate the efficacy and safety of potential therapeutic agents and vaccines proposed from the beginning of the pandemic until the present. A systematic electronic database search was conducted for relevant studies randomized controlled trials in six databases using keywords medical subject heading (MeSH) terms. In databases not supporting MeSH terms, combinations of all possible terms were used. Moreover, we conducted a manual search of references from the included articles by searching the primary studies that had cited our included papers. A total of 1,788 related articles were identified. The screening resulted in 37 records for further full-text screening. Manual search found one other paper. Finally, 13 studies were included in this systematic review. All of the reported vaccines showed acceptable efficacies and minimal side effects. However, they were not validated by big phase 3 trials, and therefore, their wide application to the public can not be recommended. Among the reported treatment modalities, convalescent plasma shows promising results in managing severe cases, while hydroxychloroquine was not efficacious as previously claimed.

Keywords:
COVID-19, treatment, vaccines, systematic review, randomised-controlled trials.


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Potential vaccines and common treatments for COVID-19: a systematic review of randomized controlled trials


Authors
Amjad Saud Alrowili
Clinical pharmacist, King Saud University, King Saud Medical City, Riyadh, Saudi Arabia.
PubMed articlesGoogle scholar articles


Correspondence to:
. Clinical pharmacist, King Saud University, King Saud Medical City, Riyadh, Saudi Arabia.; aljod.saad@gmail.com

Publication history
Received 28 Feb 2022
Accepted 11 Mar 2022
Published online 28 Mar 2022
Published in print 11 Apr 2022

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Pubmed Style

Amjad Saud Alrowili. Potential vaccines and common treatments for COVID-19: a systematic review of randomized controlled trials. IJMDC. 2022; 6(5): 760-767. doi:10.24911/IJMDC.51-1646055399


Web Style

Amjad Saud Alrowili. Potential vaccines and common treatments for COVID-19: a systematic review of randomized controlled trials. https://www.ijmdc.com/?mno=95018 [Access: July 03, 2022]. doi:10.24911/IJMDC.51-1646055399


AMA (American Medical Association) Style

Amjad Saud Alrowili. Potential vaccines and common treatments for COVID-19: a systematic review of randomized controlled trials. IJMDC. 2022; 6(5): 760-767. doi:10.24911/IJMDC.51-1646055399


Vancouver/ICMJE Style

Amjad Saud Alrowili. Potential vaccines and common treatments for COVID-19: a systematic review of randomized controlled trials. IJMDC. (2022), [cited July 03, 2022]; 6(5): 760-767. doi:10.24911/IJMDC.51-1646055399


Harvard Style

Amjad Saud Alrowili (2022) Potential vaccines and common treatments for COVID-19: a systematic review of randomized controlled trials. IJMDC, 6 (5), 760-767. doi:10.24911/IJMDC.51-1646055399


Turabian Style

Amjad Saud Alrowili. 2022. Potential vaccines and common treatments for COVID-19: a systematic review of randomized controlled trials. International Journal of Medicine in Developing Countries, 6 (5), 760-767. doi:10.24911/IJMDC.51-1646055399


Chicago Style

Amjad Saud Alrowili. "Potential vaccines and common treatments for COVID-19: a systematic review of randomized controlled trials." International Journal of Medicine in Developing Countries 6 (2022), 760-767. doi:10.24911/IJMDC.51-1646055399


MLA (The Modern Language Association) Style

Amjad Saud Alrowili. "Potential vaccines and common treatments for COVID-19: a systematic review of randomized controlled trials." International Journal of Medicine in Developing Countries 6.5 (2022), 760-767. Print. doi:10.24911/IJMDC.51-1646055399


APA (American Psychological Association) Style

Amjad Saud Alrowili (2022) Potential vaccines and common treatments for COVID-19: a systematic review of randomized controlled trials. International Journal of Medicine in Developing Countries, 6 (5), 760-767. doi:10.24911/IJMDC.51-1646055399


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