Original Article

IJMDC. 2021; 5(6): 1312-1316

Cross-sectional study establishing the most common causative agents for meningitis in neonates in King Abdulaziz Medical City

Authors: Mohammed Marzoog Almutairi, Abdulrahman Mohammed Altaher Aljifri, Hassan Ali Barakat, Abdulrahman Wail Linjawi, Alaa Mohammed Aljuaid.

ABSTRACT

Background: Bacterial neonatal meningitis is inflammation of the meninges in newborns. It causes lifelong severe complications in the affected neonates. Neonatal meningitis remains the biggest cause of mortality and morbidity in newborns despite advancements in screening methods and antibiotics. Thus, this study aimed to find out the most common organisms that cause neonatal meningitis (meningitis in newborns less than 3 months of age). Methodology: This cross-sectional study was conducted from 2013 to 2017. The study was conducted in the pediatric intensive care unit of King Khalid Hospital, King Abdulaziz Medical City, Jeddah. Patients diagnosed with meningitis (excluding viral) with positive cerebrospinal fluid, blood, or urine culture within the first 3 months of their lives were included. Results: The study showed that the most common organisms present in meningitis patients in neonates (<90 days) were Gram-negative, most commonly, Escherichia coli found in 37 cultures (30.3%). The second most common was Klebsiella pneumoniae found in 20 cultures (16.4%). Extended spectrum beta lactamase was found in 15 isolates (19.2%) from the Gram-negative organisms. This was the most common mechanism of resistance in the current study. For resistant Gram-positive organisms, methicillin-resistant Staphylococcus aureus was identified in only one species. Conclusion: Based on the current results, the most common organisms were E. coli and K. pneumoniae, for that continued use of ampicillin and gentamycin was recommended. However, for the resistant organisms, better empiric therapy should be administered.

Keywords:
Meningitis, neonates, cultures, resistance, organisms


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Cross-sectional study establishing the most common causative agents for meningitis in neonates in King Abdulaziz Medical City


Authors
Mohammed Marzoog Almutairi
Department of Paediatrics, King Abdulaziz Medical City, Riyadh, Saudi Arabia
PubMed articlesGoogle scholar articles

Abdulrahman Mohammed Altaher Aljifri
Department of Paediatrics, King Abdulaziz Medical City, Riyadh, Saudi Arabia
PubMed articlesGoogle scholar articles

Hassan Ali Barakat
Department of Paediatrics, King Abdulaziz Medical City, Riyadh, Saudi Arabia
PubMed articlesGoogle scholar articles

Abdulrahman Wail Linjawi
Department of Paediatrics, King Abdulaziz Medical City, Riyadh, Saudi Arabia
PubMed articlesGoogle scholar articles

Alaa Mohammed Aljuaid
College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles


Correspondence to:
. Mohammed Marzoog Almutairi, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.; mohmmad99955@gmail.com

Publication history
Received 06 May 2021
Accepted 31 May 2021
Published online 22 Jun 2021
Published in print 29 Jun 2021

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Pubmed Style

Almutairi MM, Aljifri AMA, Barakat HA, Linjawi AW, Aljuaid AM. Cross-sectional study establishing the most common causative agents for meningitis in neonates in King Abdulaziz Medical City. IJMDC. 2021; 5(6): 1312-1316. doi:10.24911/IJMDC.51-1620332752


Web Style

Almutairi MM, Aljifri AMA, Barakat HA, Linjawi AW, Aljuaid AM. Cross-sectional study establishing the most common causative agents for meningitis in neonates in King Abdulaziz Medical City. https://www.ijmdc.com/?mno=79549 [Access: September 19, 2021]. doi:10.24911/IJMDC.51-1620332752


AMA (American Medical Association) Style

Almutairi MM, Aljifri AMA, Barakat HA, Linjawi AW, Aljuaid AM. Cross-sectional study establishing the most common causative agents for meningitis in neonates in King Abdulaziz Medical City. IJMDC. 2021; 5(6): 1312-1316. doi:10.24911/IJMDC.51-1620332752


Vancouver/ICMJE Style

Almutairi MM, Aljifri AMA, Barakat HA, Linjawi AW, Aljuaid AM. Cross-sectional study establishing the most common causative agents for meningitis in neonates in King Abdulaziz Medical City. IJMDC. (2021), [cited September 19, 2021]; 5(6): 1312-1316. doi:10.24911/IJMDC.51-1620332752


Harvard Style

Almutairi, M. M., Aljifri, . A. M. A., Barakat, . H. A., Linjawi, . A. W. & Aljuaid, . A. M. (2021) Cross-sectional study establishing the most common causative agents for meningitis in neonates in King Abdulaziz Medical City. IJMDC, 5 (6), 1312-1316. doi:10.24911/IJMDC.51-1620332752


Turabian Style

Almutairi, Mohammed Marzoog, Abdulrahman Mohammed Altaher Aljifri, Hassan Ali Barakat, Abdulrahman Wail Linjawi, and Alaa Mohammed Aljuaid. 2021. Cross-sectional study establishing the most common causative agents for meningitis in neonates in King Abdulaziz Medical City. International Journal of Medicine in Developing Countries, 5 (6), 1312-1316. doi:10.24911/IJMDC.51-1620332752


Chicago Style

Almutairi, Mohammed Marzoog, Abdulrahman Mohammed Altaher Aljifri, Hassan Ali Barakat, Abdulrahman Wail Linjawi, and Alaa Mohammed Aljuaid. "Cross-sectional study establishing the most common causative agents for meningitis in neonates in King Abdulaziz Medical City." International Journal of Medicine in Developing Countries 5 (2021), 1312-1316. doi:10.24911/IJMDC.51-1620332752


MLA (The Modern Language Association) Style

Almutairi, Mohammed Marzoog, Abdulrahman Mohammed Altaher Aljifri, Hassan Ali Barakat, Abdulrahman Wail Linjawi, and Alaa Mohammed Aljuaid. "Cross-sectional study establishing the most common causative agents for meningitis in neonates in King Abdulaziz Medical City." International Journal of Medicine in Developing Countries 5.6 (2021), 1312-1316. Print. doi:10.24911/IJMDC.51-1620332752


APA (American Psychological Association) Style

Almutairi, M. M., Aljifri, . A. M. A., Barakat, . H. A., Linjawi, . A. W. & Aljuaid, . A. M. (2021) Cross-sectional study establishing the most common causative agents for meningitis in neonates in King Abdulaziz Medical City. International Journal of Medicine in Developing Countries, 5 (6), 1312-1316. doi:10.24911/IJMDC.51-1620332752


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