Original Article

IJMDC. 2022; 6(2): 258-264

Feasibility of laparoscopic surgery for large gastric gastrointestinal stromal tumors: systematic review and meta-analysis

Authors: Ayman Muheisen Salem Alhouli, Assaf Khalid Alsirhani, Abdullah Khalid Abdullah Alghutayghit, Faisal Khalid Saad Alrashed, Abdullah Alturqi Kurdi Alanazi, Ayman Muheisen Salem Alhouli, Abdulaziz Saleh Daham Aldaham.

ABSTRACT

Background: Surgical resection of gastric gastrointestinal stromal tumors (GISTs) via laparoscopy is the gold standard of treatment, but an open laparotomy is the preferred mode of treatment if the patient is unstable. This study aims at comparing the feasibility and safety of laparoscopic versus open resection for gastric GISTs larger than 5 cm. Methods: A systematic search was performed over different medical databases to identify general surgery studies, which studied the outcome of the laparoscopic group versus the open surgery group of large GIST patients. Furthermore, a meta-analysis was performed on blood loss and length of hospital stay (LOS) as primary efficacy outcomes and overall complications and recurrence rates as secondary safety outcomes. Results: Nine studies were identified involving 564 patients, 274 patients in the laparoscopic group, and 290 patients in the open surgery group. Our meta-analysis analysis showed a highly significant decrease in mean blood loss, LOS and complications rate in the laparoscopic group compared to the open surgery group (p <0.05), respectively. However, we also found a non-significant difference in the overall recurrence rate (p > 0.05). Conclusion: To conclude, the laparoscopic approach was associated with decreased length of stay, a trend to less blood loss, and common complications compared with the open surgical approach, but there was no significant difference between both groups according to tumor recurrence.

Keywords:
Laparoscopic surgery, large, GIST


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Feasibility of laparoscopic surgery for large gastric gastrointestinal stromal tumors: systematic review and meta-analysis


Authors
Ayman Muheisen Salem Alhouli
Jouf University, Al Jawf, Saudi Arabia
PubMed articlesGoogle scholar articles

Assaf Khalid Alsirhani
Jouf University, Al Jawf, Saudi Arabia
PubMed articlesGoogle scholar articles

Abdullah Khalid Abdullah Alghutayghit
Jouf University, Al Jawf, Saudi Arabia
PubMed articlesGoogle scholar articles

Faisal Khalid Saad Alrashed
Jouf University, Al Jawf, Saudi Arabia
PubMed articlesGoogle scholar articles

Abdullah Alturqi Kurdi Alanazi
Jouf University, Al Jawf, Saudi Arabia
PubMed articlesGoogle scholar articles

Ayman Muheisen Salem Alhouli
Qurayyat General Hospital, Al Qurayyat, Saudi Arabia
PubMed articlesGoogle scholar articles

Abdulaziz Saleh Daham Aldaham
Jouf University, Al Jawf, Saudi Arabia
PubMed articlesGoogle scholar articles


Correspondence to:
. Ayman Muheisen Salem Alhouli, Qurayyat General Hospital, Al Qurayyat, Saudi Arabia.; Abdullah96alturqi@gmail.com

Publication history
Received 15 Nov 2021
Accepted 05 Dec 2021
Published online 07 Dec 2021
Published in print 19 Jan 2022

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Pubmed Style

Alhouli AMS, Alsirhani AK, Alghutayghit AKA, Alrashed FKS, Alanazi AAK, Alhouli AMS, Aldaham ASD. Feasibility of laparoscopic surgery for large gastric gastrointestinal stromal tumors: systematic review and meta-analysis. IJMDC. 2022; 6(2): 258-264. doi:10.24911/IJMDC.51-1636935527


Web Style

Alhouli AMS, Alsirhani AK, Alghutayghit AKA, Alrashed FKS, Alanazi AAK, Alhouli AMS, Aldaham ASD. Feasibility of laparoscopic surgery for large gastric gastrointestinal stromal tumors: systematic review and meta-analysis. https://www.ijmdc.com/?mno=4410 [Access: May 25, 2022]. doi:10.24911/IJMDC.51-1636935527


AMA (American Medical Association) Style

Alhouli AMS, Alsirhani AK, Alghutayghit AKA, Alrashed FKS, Alanazi AAK, Alhouli AMS, Aldaham ASD. Feasibility of laparoscopic surgery for large gastric gastrointestinal stromal tumors: systematic review and meta-analysis. IJMDC. 2022; 6(2): 258-264. doi:10.24911/IJMDC.51-1636935527


Vancouver/ICMJE Style

Alhouli AMS, Alsirhani AK, Alghutayghit AKA, Alrashed FKS, Alanazi AAK, Alhouli AMS, Aldaham ASD. Feasibility of laparoscopic surgery for large gastric gastrointestinal stromal tumors: systematic review and meta-analysis. IJMDC. (2022), [cited May 25, 2022]; 6(2): 258-264. doi:10.24911/IJMDC.51-1636935527


Harvard Style

Alhouli, A. M. S., Alsirhani, . A. K., Alghutayghit, . A. K. A., Alrashed, . F. K. S., Alanazi, . A. A. K., Alhouli, . A. M. S. & Aldaham, . A. S. D. (2022) Feasibility of laparoscopic surgery for large gastric gastrointestinal stromal tumors: systematic review and meta-analysis. IJMDC, 6 (2), 258-264. doi:10.24911/IJMDC.51-1636935527


Turabian Style

Alhouli, Ayman Muheisen Salem, Assaf Khalid Alsirhani, Abdullah Khalid Abdullah Alghutayghit, Faisal Khalid Saad Alrashed, Abdullah Alturqi Kurdi Alanazi, Ayman Muheisen Salem Alhouli, and Abdulaziz Saleh Daham Aldaham. 2022. Feasibility of laparoscopic surgery for large gastric gastrointestinal stromal tumors: systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 6 (2), 258-264. doi:10.24911/IJMDC.51-1636935527


Chicago Style

Alhouli, Ayman Muheisen Salem, Assaf Khalid Alsirhani, Abdullah Khalid Abdullah Alghutayghit, Faisal Khalid Saad Alrashed, Abdullah Alturqi Kurdi Alanazi, Ayman Muheisen Salem Alhouli, and Abdulaziz Saleh Daham Aldaham. "Feasibility of laparoscopic surgery for large gastric gastrointestinal stromal tumors: systematic review and meta-analysis." International Journal of Medicine in Developing Countries 6 (2022), 258-264. doi:10.24911/IJMDC.51-1636935527


MLA (The Modern Language Association) Style

Alhouli, Ayman Muheisen Salem, Assaf Khalid Alsirhani, Abdullah Khalid Abdullah Alghutayghit, Faisal Khalid Saad Alrashed, Abdullah Alturqi Kurdi Alanazi, Ayman Muheisen Salem Alhouli, and Abdulaziz Saleh Daham Aldaham. "Feasibility of laparoscopic surgery for large gastric gastrointestinal stromal tumors: systematic review and meta-analysis." International Journal of Medicine in Developing Countries 6.2 (2022), 258-264. Print. doi:10.24911/IJMDC.51-1636935527


APA (American Psychological Association) Style

Alhouli, A. M. S., Alsirhani, . A. K., Alghutayghit, . A. K. A., Alrashed, . F. K. S., Alanazi, . A. A. K., Alhouli, . A. M. S. & Aldaham, . A. S. D. (2022) Feasibility of laparoscopic surgery for large gastric gastrointestinal stromal tumors: systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 6 (2), 258-264. doi:10.24911/IJMDC.51-1636935527


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