IJMDC. 2021; 5(3): 948-953

Antioxidant role of vitamin D and its correlation with vitamin D deficiency in adults: a systematic review

Authors: Taha Hussain Alamir, Zain Ahmed Al Shafie, Sultan Obaid Al Adwani.

ABSTRACT

Background: In the past few years, vitamin D levels have been correlated to multiple medical conditions. Furthermore, it has also been assumed to have protective roles in some situations. However, the antioxidant role of vitamin D is still controversial. This systematic review aimed to provide a holistic overview of vitamin D's antioxidant effects under different medical settings. Methods: A thorough examination of the medical databases, including OVID, Medline, PubMed, and Embase, was conducted between 2010 and 2020. The keywords used for searching the databases were: “vitamin D” AND “oxidation” OR “oxidative” OR “oxidant” AND “Adult.” The outcomes of this search were then refined to include only original research that investigated the antioxidant role of vitamin D in different medical settings. Selected trials included the type of medical setting under investigation. Result: A total of 93 articles were retrieved. After removing review articles and considering original research articles solely, 12 articles showed up. Eight research articles were to be included. Two studies included healthy adults, two studies included elderly patients; two studies included type 2 diabetes mellitus, one study included ischemic stroke patients. In contrast, one study included non-alcoholic fatty liver disease, diabetic and ischemic stroke patients showed a significant negative correlation between vitamin D levels and oxidative stress, which was controversial among healthy adults. Conclusion: Vitamin D supplementation can improve the oxidation stress status in multiple pathological conditions. Further studies are required in normal healthy adults.

Keywords:
Vitamin D, role, deficiency, supplementation, adults, antioxidant.


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Antioxidant role of vitamin D and its correlation with vitamin D deficiency in adults: a systematic review


Authors
Taha Hussain Alamir
Specialist, Clinical Nutrition, Sharura Armed Forces Hospital, SharuraArmed Forces Hospital, Saudi Arabia
PubMed articlesGoogle scholar articles

Zain Ahmed Al Shafie
Consultant, Family and Community Medicine, Sharura Armed Forces Hospital, Saudi Arabia
PubMed articlesGoogle scholar articles

Sultan Obaid Al Adwani
Specialist, Health Administration, Sharura Armed Forces Hospital, Saudi Arabia.
PubMed articlesGoogle scholar articles


Correspondence to:
. Taha Hussain Alamir, Specialist, Clinical Nutrition, Sharura Armed Forces Hospital, SharuraArmed Forces Hospital, Kingdom of Saudi Arabia.; talamer41@gmail.com

Publication history
Received 30 Dec 2020
Accepted 21 Jan 2021
Published online 21 Jan 2021
Published in print 04 Mar 2021

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Pubmed Style

Alamir TH, Shafie ZAA, Adwani SOA. Antioxidant role of vitamin D and its correlation with vitamin D deficiency in adults: a systematic review. IJMDC. 2021; 5(3): 948-953. doi:10.24911/IJMDC.51-1609350238


Web Style

Alamir TH, Shafie ZAA, Adwani SOA. Antioxidant role of vitamin D and its correlation with vitamin D deficiency in adults: a systematic review. http://www.ijmdc.com/?mno=38082 [Access: April 22, 2021]. doi:10.24911/IJMDC.51-1609350238


AMA (American Medical Association) Style

Alamir TH, Shafie ZAA, Adwani SOA. Antioxidant role of vitamin D and its correlation with vitamin D deficiency in adults: a systematic review. IJMDC. 2021; 5(3): 948-953. doi:10.24911/IJMDC.51-1609350238


Vancouver/ICMJE Style

Alamir TH, Shafie ZAA, Adwani SOA. Antioxidant role of vitamin D and its correlation with vitamin D deficiency in adults: a systematic review. IJMDC. (2021), [cited April 22, 2021]; 5(3): 948-953. doi:10.24911/IJMDC.51-1609350238


Harvard Style

Alamir, T. H., Shafie, . Z. A. A. & Adwani, . S. O. A. (2021) Antioxidant role of vitamin D and its correlation with vitamin D deficiency in adults: a systematic review. IJMDC, 5 (3), 948-953. doi:10.24911/IJMDC.51-1609350238


Turabian Style

Alamir, Taha Hussain, Zain Ahmed Al Shafie, and Sultan Obaid Al Adwani. 2021. Antioxidant role of vitamin D and its correlation with vitamin D deficiency in adults: a systematic review. International Journal of Medicine in Developing Countries, 5 (3), 948-953. doi:10.24911/IJMDC.51-1609350238


Chicago Style

Alamir, Taha Hussain, Zain Ahmed Al Shafie, and Sultan Obaid Al Adwani. "Antioxidant role of vitamin D and its correlation with vitamin D deficiency in adults: a systematic review." International Journal of Medicine in Developing Countries 5 (2021), 948-953. doi:10.24911/IJMDC.51-1609350238


MLA (The Modern Language Association) Style

Alamir, Taha Hussain, Zain Ahmed Al Shafie, and Sultan Obaid Al Adwani. "Antioxidant role of vitamin D and its correlation with vitamin D deficiency in adults: a systematic review." International Journal of Medicine in Developing Countries 5.3 (2021), 948-953. Print. doi:10.24911/IJMDC.51-1609350238


APA (American Psychological Association) Style

Alamir, T. H., Shafie, . Z. A. A. & Adwani, . S. O. A. (2021) Antioxidant role of vitamin D and its correlation with vitamin D deficiency in adults: a systematic review. International Journal of Medicine in Developing Countries, 5 (3), 948-953. doi:10.24911/IJMDC.51-1609350238


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