Review Article
IJMDC. 2021; 5(11): 1988-1995
Antioxidant properties of Zamzam water: a review for arsenic concerns and potential modulation of drug toxicity
Authors: Naif Aljuhani.
ABSTRACT
Zamzam water is a well-known natural alkaline (pH: 8) drinking water originating from Zamzam well in Makkah (Saudi Arabia) that needs many research efforts being consumed worldwide. A recently published German study confirmed the purity, alkalinity, and stability of Zamzam water components. Zamzam water confers many health benefits and tissue-protective benefits that are promising based on the high mineral and electrolyte contents that correct dehydration and relieve malnutrition besides water alkalinity gastro-esophageal conditions and metabolic acidosis. Pharmacologically, Zamzam water exerts antioxidant hepatoprotective effects against toxins-induced oxidative stress (against carbon tetrachloride and other toxins). Mineral contents of Zamzam water cannot be gained from any other drinking water source except for food. Absent signs, symptoms, and clinical reports of arsenic toxicity greatly relieve British Broadcasting Corporation concerns regarding the consumption of Zamzam water. Reported arsenic concentrations in Zamzam water produce arsenic trioxide (anti-leukemia). Also, co-administration of antioxidants and arsenicals abolished arsenic-induced cellular cytotoxicity. Zamzam waters overall antioxidant effects strongly support its therapeutic roles as potential antitoxic water, a pharmacological property that may better be utilized in clinical toxicology and treating different kinds of toxicities. We emphasize many drugs-induced free radicals through drug metabolism and discuss biochemical pathways that describe drug metabolites disposition in humans. In this review article, all these issues are discussed.
Keywords:
Zamzam water, ROS, antioxidant, arsenic, GSH, drugs
Authors
Naif Aljuhani
Pharmacology and Toxicology Department, Faculty of Pharmacy, Taibah University, Madinah, Saudi Arabia
PubMed articlesGoogle scholar articles
Correspondence to:
. Naif Aljuhani, Pharmacology and Toxicology Department, Faculty of Pharmacy, Taibah University, Madinah, Saudi Arabia.; Njohany@taibahu.edu.sa
Publication history
Received 07 Nov 2020
Accepted 19 Nov 2020
Published online 30 Oct 2021
Published in print 18 Nov 2021
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Naif Aljuhani. Antioxidant properties of Zamzam water: a review for arsenic concerns and potential modulation of drug toxicity. IJMDC. 2021; 5(11): 1988-1995. doi:10.24911/IJMDC.51-1604775624
Web Style
Naif Aljuhani. Antioxidant properties of Zamzam water: a review for arsenic concerns and potential modulation of drug toxicity. https://www.ijmdc.com/?mno=27665 [Access: August 18, 2022]. doi:10.24911/IJMDC.51-1604775624
AMA (American Medical Association) Style
Naif Aljuhani. Antioxidant properties of Zamzam water: a review for arsenic concerns and potential modulation of drug toxicity. IJMDC. 2021; 5(11): 1988-1995. doi:10.24911/IJMDC.51-1604775624
Vancouver/ICMJE Style
Naif Aljuhani. Antioxidant properties of Zamzam water: a review for arsenic concerns and potential modulation of drug toxicity. IJMDC. (2021), [cited August 18, 2022]; 5(11): 1988-1995. doi:10.24911/IJMDC.51-1604775624
Harvard Style
Naif Aljuhani (2021) Antioxidant properties of Zamzam water: a review for arsenic concerns and potential modulation of drug toxicity. IJMDC, 5 (11), 1988-1995. doi:10.24911/IJMDC.51-1604775624
Turabian Style
Naif Aljuhani. 2021. Antioxidant properties of Zamzam water: a review for arsenic concerns and potential modulation of drug toxicity. International Journal of Medicine in Developing Countries, 5 (11), 1988-1995. doi:10.24911/IJMDC.51-1604775624
Chicago Style
Naif Aljuhani. "Antioxidant properties of Zamzam water: a review for arsenic concerns and potential modulation of drug toxicity." International Journal of Medicine in Developing Countries 5 (2021), 1988-1995. doi:10.24911/IJMDC.51-1604775624
MLA (The Modern Language Association) Style
Naif Aljuhani. "Antioxidant properties of Zamzam water: a review for arsenic concerns and potential modulation of drug toxicity." International Journal of Medicine in Developing Countries 5.11 (2021), 1988-1995. Print. doi:10.24911/IJMDC.51-1604775624
APA (American Psychological Association) Style
Naif Aljuhani (2021) Antioxidant properties of Zamzam water: a review for arsenic concerns and potential modulation of drug toxicity. International Journal of Medicine in Developing Countries, 5 (11), 1988-1995. doi:10.24911/IJMDC.51-1604775624
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