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Review Article
Online Published: 28 May 2025
 


The role of vitamin D supplementation in preventing recurrent wheezing in pediatric asthma: a systematic review

Fahad Alamr, Saja Ahmed Naser Ameri, Noor Tuhayf Mohammed Alqahtani, Wajd Hamad Abdulaziz Alali, Rana Khalid Safran Alzaidi, Rand Nasser Abdullah Alzamil, Majedah Mohammed Nafea Alanazi, Zaher Muslih S. Hafiz, Dina Mushabab Ghazi Alotaibi, Noura Mohnnad Adel Aldaosari.


Abstract
Among asthmatic children, recurrent wheezing is considered a major complication and a significant health concern. Emerging evidence in the literature suggests a potential association between vitamin D deficiency and respiratory disorders, given its immunomodulatory role in reducing airway inflammation. However, the effectiveness of vitamin D supplementation in reducing recurrent wheezing remains controversial. The current systematic review aimed to evaluate the role of vitamin D and vitamin D supplements on wheezing progression in pediatric populations. This systematic review was conducted among studies in literature across different databases, in order to collect relevant studies published up to the year 2025. Inclusion criteria included randomized controlled studies, cohort studies, and observational studies that assessed the association between vitamin D level, vitamin D supplementation, and recurrent wheezing among children. This review included 10 studies among 3,552 children, where most of the studies reported a significant relationship between low levels of vitamin D and an increase in episodes of wheezing. Several studies reported that the use of vitamin D supplementation led to a reduction in wheezing frequency and severity, particularly among children with baseline low vitamin D. However, one study showed no significant improvement in asthma control or exacerbation rates. The findings suggested that vitamin D supplementation might be beneficial in reducing recurrent wheezing episodes in children, particularly in those with vitamin D deficiency. However, due to inconsistencies in study results, further well-designed randomized controlled trials with standardized supplementation protocols are needed to confirm these effects and establish optimal dosing strategies.

Key words: Vitamin D, supplementation, recurrent wheezing, pediatric asthma, systematic review


 
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How to Cite this Article
Pubmed Style

Alamr F, Ameri SAN, Alqahtani NTM, Alali WHA, Alzaidi RKS, Alzamil RNA, Alanazi MMN, Hafiz ZMS, Alotaibi DMG, Aldaosari NMA. The role of vitamin D supplementation in preventing recurrent wheezing in pediatric asthma: a systematic review. IJMDC. 2025; 9(5): 1212-1218. doi:10.24911/IJMDC.51-1741961073

Web Style

Alamr F, Ameri SAN, Alqahtani NTM, Alali WHA, Alzaidi RKS, Alzamil RNA, Alanazi MMN, Hafiz ZMS, Alotaibi DMG, Aldaosari NMA. The role of vitamin D supplementation in preventing recurrent wheezing in pediatric asthma: a systematic review. https://www.ijmdc.com/?mno=247444 [Access: October 14, 2025]. doi:10.24911/IJMDC.51-1741961073

AMA (American Medical Association) Style

Alamr F, Ameri SAN, Alqahtani NTM, Alali WHA, Alzaidi RKS, Alzamil RNA, Alanazi MMN, Hafiz ZMS, Alotaibi DMG, Aldaosari NMA. The role of vitamin D supplementation in preventing recurrent wheezing in pediatric asthma: a systematic review. IJMDC. 2025; 9(5): 1212-1218. doi:10.24911/IJMDC.51-1741961073


Vancouver/ICMJE Style

Alamr F, Ameri SAN, Alqahtani NTM, Alali WHA, Alzaidi RKS, Alzamil RNA, Alanazi MMN, Hafiz ZMS, Alotaibi DMG, Aldaosari NMA. The role of vitamin D supplementation in preventing recurrent wheezing in pediatric asthma: a systematic review. IJMDC. (2025), [cited October 14, 2025]; 9(5): 1212-1218. doi:10.24911/IJMDC.51-1741961073


Harvard Style

Alamr, F., Ameri, . S. A. N., Alqahtani, . N. T. M., Alali, . W. H. A., Alzaidi, . R. K. S., Alzamil, . R. N. A., Alanazi, . M. M. N., Hafiz, . Z. M. S., Alotaibi, . D. M. G. & Aldaosari, . N. M. A. (2025) The role of vitamin D supplementation in preventing recurrent wheezing in pediatric asthma: a systematic review. IJMDC, 9 (5), 1212-1218. doi:10.24911/IJMDC.51-1741961073


Turabian Style

Alamr, Fahad, Saja Ahmed Naser Ameri, Noor Tuhayf Mohammed Alqahtani, Wajd Hamad Abdulaziz Alali, Rana Khalid Safran Alzaidi, Rand Nasser Abdullah Alzamil, Majedah Mohammed Nafea Alanazi, Zaher Muslih S. Hafiz, Dina Mushabab Ghazi Alotaibi, and Noura Mohnnad Adel Aldaosari. 2025. The role of vitamin D supplementation in preventing recurrent wheezing in pediatric asthma: a systematic review. International Journal of Medicine in Developing Countries, 9 (5), 1212-1218. doi:10.24911/IJMDC.51-1741961073


Chicago Style

Alamr, Fahad, Saja Ahmed Naser Ameri, Noor Tuhayf Mohammed Alqahtani, Wajd Hamad Abdulaziz Alali, Rana Khalid Safran Alzaidi, Rand Nasser Abdullah Alzamil, Majedah Mohammed Nafea Alanazi, Zaher Muslih S. Hafiz, Dina Mushabab Ghazi Alotaibi, and Noura Mohnnad Adel Aldaosari. "The role of vitamin D supplementation in preventing recurrent wheezing in pediatric asthma: a systematic review." International Journal of Medicine in Developing Countries 9 (2025), 1212-1218. doi:10.24911/IJMDC.51-1741961073


MLA (The Modern Language Association) Style

Alamr, Fahad, Saja Ahmed Naser Ameri, Noor Tuhayf Mohammed Alqahtani, Wajd Hamad Abdulaziz Alali, Rana Khalid Safran Alzaidi, Rand Nasser Abdullah Alzamil, Majedah Mohammed Nafea Alanazi, Zaher Muslih S. Hafiz, Dina Mushabab Ghazi Alotaibi, and Noura Mohnnad Adel Aldaosari. "The role of vitamin D supplementation in preventing recurrent wheezing in pediatric asthma: a systematic review." International Journal of Medicine in Developing Countries 9.5 (2025), 1212-1218. Print. doi:10.24911/IJMDC.51-1741961073


APA (American Psychological Association) Style

Alamr, F., Ameri, . S. A. N., Alqahtani, . N. T. M., Alali, . W. H. A., Alzaidi, . R. K. S., Alzamil, . R. N. A., Alanazi, . M. M. N., Hafiz, . Z. M. S., Alotaibi, . D. M. G. & Aldaosari, . N. M. A. (2025) The role of vitamin D supplementation in preventing recurrent wheezing in pediatric asthma: a systematic review. International Journal of Medicine in Developing Countries, 9 (5), 1212-1218. doi:10.24911/IJMDC.51-1741961073




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