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Review Article
Online Published: 07 May 2025
 


Risk factors, incidence, and treatment options for post-LASIK regression: a systematic review

Abdulrahman M. Alamri, Muzun Aedh Asiri, Nawal Mohammed Asiri, Manar Ali Alqahtani, Atheel Ali Alshehri, Rahaf Abdulaziz Alamri, Majd Abdullah Sultan, Rawan Abdulmohsen Alqarni, Salwa Abdullah Bin Qaed, Raghad Abdulaziz Alamri, Ayman Abdullah Alshehri.


Abstract
Background: Laser in situ keratomileusis (LASIK) describes the use of excimer laser ablation on the stromal bed to reshape the cornea and it is now one of the most commonly performed elective procedures across the world. However, the postoperative course of LASIK can be hindered by refractive regression, defined as a tendency of the eye to return toward its original refraction. Regression has a detrimental effect on long-term stability and predictability of LASIK. It can impair visual performance and quality of life. The primary aim of this systematic review was to comprehensively collate and analyze existing research on post-LASIK regression.
Methods: This was a narrative systematic review of the literature. Databases were systematically searched for studies about regression of visual acuity after LASIK surgery for myopia treatment. It included patients aged 18 years and above, with stable refractive errors, and those without autoimmune diseases or diabetes. The review included 16 articles. The risk of bias was assessed, and then the data were qualitatively analyzed.
Results: Myopic regression after LASIK surgery is a common issue, with an average incidence of 25% to 31%. Risk factors include older age, aspherical ablation, larger treatment zone, higher preoperative myopia, and smaller optical zone. Treatment options include routine postoperative review, artificial tears, and topical therapy. Alternative refractive correction options include small incision lenticule extraction, which offers comparable results to LASIK for hyperopia correction.
Conclusions: Myopic regression after LASIK surgery, influenced by risk factors such as age and larger treatment zones, can be treated with postoperative care, artificial tears, and topical timolol therapy.

Key words: LASIK, regression, Small Incision Lenticule Extraction, eye, incidence, risk factors.


 
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How to Cite this Article
Pubmed Style

Alamri AM, Asiri MA, Asiri NM, Alqahtani MA, Alshehri AA, Alamri RA, Sultan MA, Alqarni RA, Qaed SAB, Alamri RA, Alshehri AA. Risk factors, incidence, and treatment options for post-LASIK regression: a systematic review. IJMDC. 2025; 9(4): 980-985. doi:10.24911/IJMDC.51-1741197050

Web Style

Alamri AM, Asiri MA, Asiri NM, Alqahtani MA, Alshehri AA, Alamri RA, Sultan MA, Alqarni RA, Qaed SAB, Alamri RA, Alshehri AA. Risk factors, incidence, and treatment options for post-LASIK regression: a systematic review. https://www.ijmdc.com/?mno=245966 [Access: May 14, 2025]. doi:10.24911/IJMDC.51-1741197050

AMA (American Medical Association) Style

Alamri AM, Asiri MA, Asiri NM, Alqahtani MA, Alshehri AA, Alamri RA, Sultan MA, Alqarni RA, Qaed SAB, Alamri RA, Alshehri AA. Risk factors, incidence, and treatment options for post-LASIK regression: a systematic review. IJMDC. 2025; 9(4): 980-985. doi:10.24911/IJMDC.51-1741197050


Vancouver/ICMJE Style

Alamri AM, Asiri MA, Asiri NM, Alqahtani MA, Alshehri AA, Alamri RA, Sultan MA, Alqarni RA, Qaed SAB, Alamri RA, Alshehri AA. Risk factors, incidence, and treatment options for post-LASIK regression: a systematic review. IJMDC. (2025), [cited May 14, 2025]; 9(4): 980-985. doi:10.24911/IJMDC.51-1741197050


Harvard Style

Alamri, A. M., Asiri, . M. A., Asiri, . N. M., Alqahtani, . M. A., Alshehri, . A. A., Alamri, . R. A., Sultan, . M. A., Alqarni, . R. A., Qaed, . S. A. B., Alamri, . R. A. & Alshehri, . A. A. (2025) Risk factors, incidence, and treatment options for post-LASIK regression: a systematic review. IJMDC, 9 (4), 980-985. doi:10.24911/IJMDC.51-1741197050


Turabian Style

Alamri, Abdulrahman M., Muzun Aedh Asiri, Nawal Mohammed Asiri, Manar Ali Alqahtani, Atheel Ali Alshehri, Rahaf Abdulaziz Alamri, Majd Abdullah Sultan, Rawan Abdulmohsen Alqarni, Salwa Abdullah Bin Qaed, Raghad Abdulaziz Alamri, and Ayman Abdullah Alshehri. 2025. Risk factors, incidence, and treatment options for post-LASIK regression: a systematic review. International Journal of Medicine in Developing Countries, 9 (4), 980-985. doi:10.24911/IJMDC.51-1741197050


Chicago Style

Alamri, Abdulrahman M., Muzun Aedh Asiri, Nawal Mohammed Asiri, Manar Ali Alqahtani, Atheel Ali Alshehri, Rahaf Abdulaziz Alamri, Majd Abdullah Sultan, Rawan Abdulmohsen Alqarni, Salwa Abdullah Bin Qaed, Raghad Abdulaziz Alamri, and Ayman Abdullah Alshehri. "Risk factors, incidence, and treatment options for post-LASIK regression: a systematic review." International Journal of Medicine in Developing Countries 9 (2025), 980-985. doi:10.24911/IJMDC.51-1741197050


MLA (The Modern Language Association) Style

Alamri, Abdulrahman M., Muzun Aedh Asiri, Nawal Mohammed Asiri, Manar Ali Alqahtani, Atheel Ali Alshehri, Rahaf Abdulaziz Alamri, Majd Abdullah Sultan, Rawan Abdulmohsen Alqarni, Salwa Abdullah Bin Qaed, Raghad Abdulaziz Alamri, and Ayman Abdullah Alshehri. "Risk factors, incidence, and treatment options for post-LASIK regression: a systematic review." International Journal of Medicine in Developing Countries 9.4 (2025), 980-985. Print. doi:10.24911/IJMDC.51-1741197050


APA (American Psychological Association) Style

Alamri, A. M., Asiri, . M. A., Asiri, . N. M., Alqahtani, . M. A., Alshehri, . A. A., Alamri, . R. A., Sultan, . M. A., Alqarni, . R. A., Qaed, . S. A. B., Alamri, . R. A. & Alshehri, . A. A. (2025) Risk factors, incidence, and treatment options for post-LASIK regression: a systematic review. International Journal of Medicine in Developing Countries, 9 (4), 980-985. doi:10.24911/IJMDC.51-1741197050




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