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Review Article
Online Published: 01 Jan 2025
 


Effectiveness of immunotherapy in recurrent respiratory papillomatosis; a systematic review

Hani Alanazi, Waleed Khalid Z. Alghuyaythat, Faisal Khalid A. Alluhaidan, Sarah Mastour T. Alotaibi, Albatool Falah Mohammed Aljofan, Abdullah Mastour Talaq Alotaibi, Anwar Ghudair T. Alanazi, Ahmed Hamad Alanazi, Abdulrahman Naqaa N. Almutairi.


Abstract
Recurrent respiratory papillomatosis (RRP) is a challenging clinical condition predominantly caused by human papillomavirus (HPV). Immunotherapy has emerged as a potential treatment strategy, prompting a systematic review to elucidate its effectiveness in managing RRP. The databases of Google Scholar, PubMed, Embase, Cochrane Library, Web of Science, Scopus, and CINAHL were assessed for the selection of studies pertinent to this review objectives, by the preferred reporting items for systematic reviews and meta-analyses reporting guidelines. A total of seven studies were included demonstrating that immunotherapy could reduce the frequency of surgical interventions and enhance immune system markers associated with fighting HPV. Notably, treatments that targeted programmed death-ligand 1 showed promise in reducing disease burden and extending recurrence-free intervals, particularly when compared to dual inhibition strategies, which were less effective. Significant improvements were noted in both pediatric and adult patient groups, indicating broad applicability across age ranges. Additionally, some therapies were effective in reducing papilloma volume and improving respiratory function, thereby enhancing the patient’s quality of life. Immunotherapy represented a viable option for the management of RRP, with the potential to decrease reliance on surgical interventions and modulate immune response favorably. However, the effectiveness varies based on the therapeutic approach and individual patient factors, underscoring the need for tailored treatment strategies. Continued research is essential to optimize immunotherapeutic regimens and fully understand their mechanisms of action within diverse patient populations.

Key words: Recurrent respiratory papillomatosis, immunotherapy, HPV, PD-L1 inhibition, systemic review


 
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How to Cite this Article
Pubmed Style

Alanazi H, Alghuyaythat WKZ, Alluhaidan FKA, Alotaibi SMT, Aljofan AFM, Alotaibi AMT, Alanazi AGT, Alanazi AH, Almutairi ANN. Effectiveness of immunotherapy in recurrent respiratory papillomatosis; a systematic review. IJMDC. 2024; 8(11): 3256-3269. doi:10.24911/IJMDC.51-1732089238

Web Style

Alanazi H, Alghuyaythat WKZ, Alluhaidan FKA, Alotaibi SMT, Aljofan AFM, Alotaibi AMT, Alanazi AGT, Alanazi AH, Almutairi ANN. Effectiveness of immunotherapy in recurrent respiratory papillomatosis; a systematic review. https://www.ijmdc.com/?mno=229509 [Access: January 14, 2025]. doi:10.24911/IJMDC.51-1732089238

AMA (American Medical Association) Style

Alanazi H, Alghuyaythat WKZ, Alluhaidan FKA, Alotaibi SMT, Aljofan AFM, Alotaibi AMT, Alanazi AGT, Alanazi AH, Almutairi ANN. Effectiveness of immunotherapy in recurrent respiratory papillomatosis; a systematic review. IJMDC. 2024; 8(11): 3256-3269. doi:10.24911/IJMDC.51-1732089238


Vancouver/ICMJE Style

Alanazi H, Alghuyaythat WKZ, Alluhaidan FKA, Alotaibi SMT, Aljofan AFM, Alotaibi AMT, Alanazi AGT, Alanazi AH, Almutairi ANN. Effectiveness of immunotherapy in recurrent respiratory papillomatosis; a systematic review. IJMDC. (2024), [cited January 14, 2025]; 8(11): 3256-3269. doi:10.24911/IJMDC.51-1732089238


Harvard Style

Alanazi, H., Alghuyaythat, . W. K. Z., Alluhaidan, . F. K. A., Alotaibi, . S. M. T., Aljofan, . A. F. M., Alotaibi, . A. M. T., Alanazi, . A. G. T., Alanazi, . A. H. & Almutairi, . A. N. N. (2024) Effectiveness of immunotherapy in recurrent respiratory papillomatosis; a systematic review. IJMDC, 8 (11), 3256-3269. doi:10.24911/IJMDC.51-1732089238


Turabian Style

Alanazi, Hani, Waleed Khalid Z. Alghuyaythat, Faisal Khalid A. Alluhaidan, Sarah Mastour T. Alotaibi, Albatool Falah Mohammed Aljofan, Abdullah Mastour Talaq Alotaibi, Anwar Ghudair T. Alanazi, Ahmed Hamad Alanazi, and Abdulrahman Naqaa N. Almutairi. 2024. Effectiveness of immunotherapy in recurrent respiratory papillomatosis; a systematic review. International Journal of Medicine in Developing Countries, 8 (11), 3256-3269. doi:10.24911/IJMDC.51-1732089238


Chicago Style

Alanazi, Hani, Waleed Khalid Z. Alghuyaythat, Faisal Khalid A. Alluhaidan, Sarah Mastour T. Alotaibi, Albatool Falah Mohammed Aljofan, Abdullah Mastour Talaq Alotaibi, Anwar Ghudair T. Alanazi, Ahmed Hamad Alanazi, and Abdulrahman Naqaa N. Almutairi. "Effectiveness of immunotherapy in recurrent respiratory papillomatosis; a systematic review." International Journal of Medicine in Developing Countries 8 (2024), 3256-3269. doi:10.24911/IJMDC.51-1732089238


MLA (The Modern Language Association) Style

Alanazi, Hani, Waleed Khalid Z. Alghuyaythat, Faisal Khalid A. Alluhaidan, Sarah Mastour T. Alotaibi, Albatool Falah Mohammed Aljofan, Abdullah Mastour Talaq Alotaibi, Anwar Ghudair T. Alanazi, Ahmed Hamad Alanazi, and Abdulrahman Naqaa N. Almutairi. "Effectiveness of immunotherapy in recurrent respiratory papillomatosis; a systematic review." International Journal of Medicine in Developing Countries 8.11 (2024), 3256-3269. Print. doi:10.24911/IJMDC.51-1732089238


APA (American Psychological Association) Style

Alanazi, H., Alghuyaythat, . W. K. Z., Alluhaidan, . F. K. A., Alotaibi, . S. M. T., Aljofan, . A. F. M., Alotaibi, . A. M. T., Alanazi, . A. G. T., Alanazi, . A. H. & Almutairi, . A. N. N. (2024) Effectiveness of immunotherapy in recurrent respiratory papillomatosis; a systematic review. International Journal of Medicine in Developing Countries, 8 (11), 3256-3269. doi:10.24911/IJMDC.51-1732089238




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