IJMDC. 2022; 6(6): 895-899

Biologic treatments for chronic rhinosinusitis

Authors: Kamal Hazem A. Salama, Dakheelallah Al Mutairi.

ABSTRACT

Chronic rhinosinusitis is a complex inflammatory disorder manifesting without or with nasal polyps, with the latter being more life-threatening. Current standard care practice includes antibiotics, sinus surgery, and topical and systemic glucocorticosteroids individually or in different combinations. Despite their widespread acceptance, current treatments do not eliminate the reoccurrence of the condition insignificant number of patients. Recently, biologics have proven to be successful for different conditions including asthma. The biologics currently used are immunoglobin-E (IgE) targeting, interleukin (IL) 3,4, and 5 targeting. Omalizumab, Ligelizumab, and M1’ antibody are IgE targeting. Omalizumab binds to IgE receptors, while ligelizumab binds to IgE itself and M1 antibody induces apoptosis in B cells, collectively reducing serum IgE. Mepolizumab and Reslizumab are IL-5 targeting biologics working by either binding to free IL-5 or binding to IL-5 receptors, respectively. Pascolizumab and soluble recombinant IL-4 receptors bind to free IL-4. Lastly, lebrikizumab binds to free IL-3 ensuring it doesn’t bind to its receptors. Currently, only omalizumab is food and drug administration-approved. Given their success in treating asthma patients and a dire need for effective care plans to help improve the quality of life of patients, this study should serve as a clarion call for the scientific community to study these biologics and introduce standardized treatment plan powered by randomized control trials.

Keywords:
Biologic Treatments, Chronic Rhinosinusitis, asthma, nasal polyposis


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Biologic treatments for chronic rhinosinusitis


Authors
Kamal Hazem A Salama
Medical Student, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles

Dakheelallah Al Mutairi
College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia, King Abdullah International Medical Research Center, Jeddah, Saudi Arabia, Department of Otolaryngology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia.
PubMed articlesGoogle scholar articles


Correspondence to:
. Kamal Hazem A. Salama, Medical Student, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.; drkamalsalamah@gmail.com

Publication history
Received 17 Apr 2022
Accepted 24 Apr 2022
Published online 12 May 2022
Published in print 04 Jun 2022

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Pubmed Style

Salama KHA, Mutairi DA. Biologic treatments for chronic rhinosinusitis. IJMDC. 2022; 6(6): 895-899. doi:10.24911/IJMDC.51-1650155776


Web Style

Salama KHA, Mutairi DA. Biologic treatments for chronic rhinosinusitis. https://www.ijmdc.com/?mno=18470 [Access: August 18, 2022]. doi:10.24911/IJMDC.51-1650155776


AMA (American Medical Association) Style

Salama KHA, Mutairi DA. Biologic treatments for chronic rhinosinusitis. IJMDC. 2022; 6(6): 895-899. doi:10.24911/IJMDC.51-1650155776


Vancouver/ICMJE Style

Salama KHA, Mutairi DA. Biologic treatments for chronic rhinosinusitis. IJMDC. (2022), [cited August 18, 2022]; 6(6): 895-899. doi:10.24911/IJMDC.51-1650155776


Harvard Style

Salama, K. H. A. & Mutairi, . D. A. (2022) Biologic treatments for chronic rhinosinusitis. IJMDC, 6 (6), 895-899. doi:10.24911/IJMDC.51-1650155776


Turabian Style

Salama, Kamal Hazem A., and Dakheelallah Al Mutairi. 2022. Biologic treatments for chronic rhinosinusitis. International Journal of Medicine in Developing Countries, 6 (6), 895-899. doi:10.24911/IJMDC.51-1650155776


Chicago Style

Salama, Kamal Hazem A., and Dakheelallah Al Mutairi. "Biologic treatments for chronic rhinosinusitis." International Journal of Medicine in Developing Countries 6 (2022), 895-899. doi:10.24911/IJMDC.51-1650155776


MLA (The Modern Language Association) Style

Salama, Kamal Hazem A., and Dakheelallah Al Mutairi. "Biologic treatments for chronic rhinosinusitis." International Journal of Medicine in Developing Countries 6.6 (2022), 895-899. Print. doi:10.24911/IJMDC.51-1650155776


APA (American Psychological Association) Style

Salama, K. H. A. & Mutairi, . D. A. (2022) Biologic treatments for chronic rhinosinusitis. International Journal of Medicine in Developing Countries, 6 (6), 895-899. doi:10.24911/IJMDC.51-1650155776


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