The association between vitamin A deficiency and chalazion: a systematic review

Fatima Ismaeel Alhumaid; Abdullah Hussein Al Ibrahim; Waleed Mohammed Alshehri; Ahmed Mohammed Albelowi; Shaikha Aleid

doi:10.24911/IJMDC.51-1693136856

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Review Article
Online Published: 09 Oct 2023

IJMDC. 2023; 7(12): 1766-1771

doi: 10.24911/IJMDC.51-1693136856

The association between vitamin A deficiency and chalazion: a systematic review

Fatima Ismaeel Alhumaid, Abdullah Hussein Al Ibrahim, Waleed Mohammed Alshehri, Ahmed Mohammed Albelowi, Shaikha Aleid.

Abstract
Background: A chalazion is a common eye condition resulting from the accumulation of sebaceous secretions due to an obstructed meibomian gland which eventually will elicit the formation of a lipo-granulomatous reac tion. Recent attention is directed to vitamin A deficiency, being one of the contributing risk factors that have been studied, particularly in children. Vitamin A deficiency is common in certain geographical distributions due to the lack of access to vitamin A-rich nutrients, resulting in a wide range of related ocular morbidities.
Methodology: We aim to systemically review the available literature on the role of vitamin A deficiency in chalazion development. The search for relevant studies was carried out with the use of four databases: PubMed, Scopus, Web of Science, and Cochrane. After screening the search results, removing duplicates, and assessing the eligibility of the retrieved ones, a total of four studies were found to be eligible and hence, included in the review.
Results: One study that assessed the association of vitamin A and D with the risk of chalazion after collecting blood samples from cases and control groups has shown that vitamin A deficiency in the group of patients with chalazion (52.2%) was much higher than the control group (28.6%) with no significant difference in vitamin D levels between the two subjects. Similar results were concluded from the other studies as well.
Conclusion: To conclude, the available studies in the literature support the association of vitamin A with chalazion, although insufficient. Further studies are needed to support the available evidence.

Key words: Chalazion, chalazia, vitamin A deficiency, retinol deficiency, meibomian gland.

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Pubmed Style

Alhumaid FI, Ibrahim AHA, Alshehri WM, Albelowi AM, Aleid S. The association between vitamin A deficiency and chalazion: a systematic review. IJMDC. 2023; 7(12): 1766-1771. doi:10.24911/IJMDC.51-1693136856

Web Style

Alhumaid FI, Ibrahim AHA, Alshehri WM, Albelowi AM, Aleid S. The association between vitamin A deficiency and chalazion: a systematic review. https://www.ijmdc.com/?mno=167088 [Access: January 14, 2025]. doi:10.24911/IJMDC.51-1693136856

AMA (American Medical Association) Style

Alhumaid FI, Ibrahim AHA, Alshehri WM, Albelowi AM, Aleid S. The association between vitamin A deficiency and chalazion: a systematic review. IJMDC. 2023; 7(12): 1766-1771. doi:10.24911/IJMDC.51-1693136856

Vancouver/ICMJE Style

Alhumaid FI, Ibrahim AHA, Alshehri WM, Albelowi AM, Aleid S. The association between vitamin A deficiency and chalazion: a systematic review. IJMDC. (2023), [cited January 14, 2025]; 7(12): 1766-1771. doi:10.24911/IJMDC.51-1693136856

Harvard Style

Alhumaid, F. I., Ibrahim, . A. H. A., Alshehri, . W. M., Albelowi, . A. M. & Aleid, . S. (2023) The association between vitamin A deficiency and chalazion: a systematic review. IJMDC, 7 (12), 1766-1771. doi:10.24911/IJMDC.51-1693136856

Turabian Style

Alhumaid, Fatima Ismaeel, Abdullah Hussein Al Ibrahim, Waleed Mohammed Alshehri, Ahmed Mohammed Albelowi, and Shaikha Aleid. 2023. The association between vitamin A deficiency and chalazion: a systematic review. International Journal of Medicine in Developing Countries, 7 (12), 1766-1771. doi:10.24911/IJMDC.51-1693136856

Chicago Style

Alhumaid, Fatima Ismaeel, Abdullah Hussein Al Ibrahim, Waleed Mohammed Alshehri, Ahmed Mohammed Albelowi, and Shaikha Aleid. "The association between vitamin A deficiency and chalazion: a systematic review." International Journal of Medicine in Developing Countries 7 (2023), 1766-1771. doi:10.24911/IJMDC.51-1693136856

MLA (The Modern Language Association) Style

Alhumaid, Fatima Ismaeel, Abdullah Hussein Al Ibrahim, Waleed Mohammed Alshehri, Ahmed Mohammed Albelowi, and Shaikha Aleid. "The association between vitamin A deficiency and chalazion: a systematic review." International Journal of Medicine in Developing Countries 7.12 (2023), 1766-1771. Print. doi:10.24911/IJMDC.51-1693136856

APA (American Psychological Association) Style

Alhumaid, F. I., Ibrahim, . A. H. A., Alshehri, . W. M., Albelowi, . A. M. & Aleid, . S. (2023) The association between vitamin A deficiency and chalazion: a systematic review. International Journal of Medicine in Developing Countries, 7 (12), 1766-1771. doi:10.24911/IJMDC.51-1693136856

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