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2025, Vol: 9, Issue: 9
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Review Article
Online Published: 23 Sep 2023
 


Pethidine-related neurotoxicity in pediatric sickle cell disease: a systematic review

Khaled Ali Almasoud, Atheer Fahad Aldaghmi, Amna Ali Alahmed, Mansour Mana Alzamanan, Ali Hussain Majrashi.


Abstract
Sickle cell disease describes a set of related blood disorders that result from defective production of hemoglobin that causes rigid fibers to form in the red blood cells, bending them into a characteristic sickle shape. These misshapen blood cells are then prone to becoming lodged in smaller blood vessels, resulting in a vaso-occlusive crisis, which can be very painful. Rapid and potent analgesia is crucial in the care of patients presenting with sickle cell crisis, and opioid analgesics, such as pethidine and morphine, have been the mainstay of treatment for decades. However, there are reports in the literature of seizures associated with pethidine use, particularly if used for more than a few days or in patients with kidney disease. A systematic review of the literature was conducted to identify any case reports or studies of the use of pethidine in children presenting with painful sickle cell crisis with a specific focus on the prevalence of seizures in this patient group. The pharmacology and pharmacokinetics of pethidine and its active metabolite norpethidine are briefly explored, along with alternative analgesic approaches, both pharmacological and nonpharmacological.

Key words: Pethidine , Neurotoxicity , sickle cell disease , paediatric , systematic review.


 
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How to Cite this Article
Pubmed Style

Almasoud KA, Aldaghmi AF, Alahmed AA, Alzamanan MM, Majrashi AH. Pethidine-related neurotoxicity in pediatric sickle cell disease: a systematic review. IJMDC. 2023; 7(12): 1758-1765. doi:10.24911/IJMDC.51-1693034094

Web Style

Almasoud KA, Aldaghmi AF, Alahmed AA, Alzamanan MM, Majrashi AH. Pethidine-related neurotoxicity in pediatric sickle cell disease: a systematic review. https://www.ijmdc.com/?mno=166984 [Access: October 14, 2025]. doi:10.24911/IJMDC.51-1693034094

AMA (American Medical Association) Style

Almasoud KA, Aldaghmi AF, Alahmed AA, Alzamanan MM, Majrashi AH. Pethidine-related neurotoxicity in pediatric sickle cell disease: a systematic review. IJMDC. 2023; 7(12): 1758-1765. doi:10.24911/IJMDC.51-1693034094


Vancouver/ICMJE Style

Almasoud KA, Aldaghmi AF, Alahmed AA, Alzamanan MM, Majrashi AH. Pethidine-related neurotoxicity in pediatric sickle cell disease: a systematic review. IJMDC. (2023), [cited October 14, 2025]; 7(12): 1758-1765. doi:10.24911/IJMDC.51-1693034094


Harvard Style

Almasoud, K. A., Aldaghmi, . A. F., Alahmed, . A. A., Alzamanan, . M. M. & Majrashi, . A. H. (2023) Pethidine-related neurotoxicity in pediatric sickle cell disease: a systematic review. IJMDC, 7 (12), 1758-1765. doi:10.24911/IJMDC.51-1693034094


Turabian Style

Almasoud, Khaled Ali, Atheer Fahad Aldaghmi, Amna Ali Alahmed, Mansour Mana Alzamanan, and Ali Hussain Majrashi. 2023. Pethidine-related neurotoxicity in pediatric sickle cell disease: a systematic review. International Journal of Medicine in Developing Countries, 7 (12), 1758-1765. doi:10.24911/IJMDC.51-1693034094


Chicago Style

Almasoud, Khaled Ali, Atheer Fahad Aldaghmi, Amna Ali Alahmed, Mansour Mana Alzamanan, and Ali Hussain Majrashi. "Pethidine-related neurotoxicity in pediatric sickle cell disease: a systematic review." International Journal of Medicine in Developing Countries 7 (2023), 1758-1765. doi:10.24911/IJMDC.51-1693034094


MLA (The Modern Language Association) Style

Almasoud, Khaled Ali, Atheer Fahad Aldaghmi, Amna Ali Alahmed, Mansour Mana Alzamanan, and Ali Hussain Majrashi. "Pethidine-related neurotoxicity in pediatric sickle cell disease: a systematic review." International Journal of Medicine in Developing Countries 7.12 (2023), 1758-1765. Print. doi:10.24911/IJMDC.51-1693034094


APA (American Psychological Association) Style

Almasoud, K. A., Aldaghmi, . A. F., Alahmed, . A. A., Alzamanan, . M. M. & Majrashi, . A. H. (2023) Pethidine-related neurotoxicity in pediatric sickle cell disease: a systematic review. International Journal of Medicine in Developing Countries, 7 (12), 1758-1765. doi:10.24911/IJMDC.51-1693034094




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