E-ISSN 1658-7820
 
2024, Vol: 8, Issue: 5
8 / 5Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Review Article

Online Publishing Date:
23 / 09 / 2023

 


Pethidine-related neurotoxicity in pediatric sickle cell disease: a systematic review

Khaled Ali Almasoud, Atheer Fahad Aldaghmi, Amna Ali Alahmed, Mansour Mana Alzamanan, Ali Hussain Majrashi.


Abstract
Sickle cell disease describes a set of related blood disorders that result from defective production of hemoglobin that causes rigid fibers to form in the red blood cells, bending them into a characteristic sickle shape. These misshapen blood cells are then prone to becoming lodged in smaller blood vessels, resulting in a vaso-occlusive crisis, which can be very painful. Rapid and potent analgesia is crucial in the care of patients presenting with sickle cell crisis, and opioid analgesics, such as pethidine and morphine, have been the mainstay of treatment for decades. However, there are reports in the literature of seizures associated with pethidine use, particularly if used for more than a few days or in patients with kidney disease. A systematic review of the literature was conducted to identify any case reports or studies of the use of pethidine in children presenting with painful sickle cell crisis with a specific focus on the prevalence of seizures in this patient group. The pharmacology and pharmacokinetics of pethidine and its active metabolite norpethidine are briefly explored, along with alternative analgesic approaches, both pharmacological and nonpharmacological.

Key words: Pethidine , Neurotoxicity , sickle cell disease , paediatric , systematic review.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Khaled Ali Almasoud
Articles by Atheer Fahad Aldaghmi
Articles by Amna Ali Alahmed
Articles by Mansour Mana Alzamanan
Articles by Ali Hussain Majrashi
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Almasoud KA, Aldaghmi AF, Alahmed AA, Alzamanan MM, Majrashi AH. Pethidine-related neurotoxicity in pediatric sickle cell disease: a systematic review. IJMDC. 2023; 7(12): 1758-1765. doi:10.24911/IJMDC.51-1693034094

Web Style

Almasoud KA, Aldaghmi AF, Alahmed AA, Alzamanan MM, Majrashi AH. Pethidine-related neurotoxicity in pediatric sickle cell disease: a systematic review. https://www.ijmdc.com/?mno=166984 [Access: March 27, 2024]. doi:10.24911/IJMDC.51-1693034094

AMA (American Medical Association) Style

Almasoud KA, Aldaghmi AF, Alahmed AA, Alzamanan MM, Majrashi AH. Pethidine-related neurotoxicity in pediatric sickle cell disease: a systematic review. IJMDC. 2023; 7(12): 1758-1765. doi:10.24911/IJMDC.51-1693034094


Vancouver/ICMJE Style

Almasoud KA, Aldaghmi AF, Alahmed AA, Alzamanan MM, Majrashi AH. Pethidine-related neurotoxicity in pediatric sickle cell disease: a systematic review. IJMDC. (2023), [cited March 27, 2024]; 7(12): 1758-1765. doi:10.24911/IJMDC.51-1693034094


Harvard Style

Almasoud, K. A., Aldaghmi, . A. F., Alahmed, . A. A., Alzamanan, . M. M. & Majrashi, . A. H. (2023) Pethidine-related neurotoxicity in pediatric sickle cell disease: a systematic review. IJMDC, 7 (12), 1758-1765. doi:10.24911/IJMDC.51-1693034094


Turabian Style

Almasoud, Khaled Ali, Atheer Fahad Aldaghmi, Amna Ali Alahmed, Mansour Mana Alzamanan, and Ali Hussain Majrashi. 2023. Pethidine-related neurotoxicity in pediatric sickle cell disease: a systematic review. International Journal of Medicine in Developing Countries, 7 (12), 1758-1765. doi:10.24911/IJMDC.51-1693034094


Chicago Style

Almasoud, Khaled Ali, Atheer Fahad Aldaghmi, Amna Ali Alahmed, Mansour Mana Alzamanan, and Ali Hussain Majrashi. "Pethidine-related neurotoxicity in pediatric sickle cell disease: a systematic review." International Journal of Medicine in Developing Countries 7 (2023), 1758-1765. doi:10.24911/IJMDC.51-1693034094


MLA (The Modern Language Association) Style

Almasoud, Khaled Ali, Atheer Fahad Aldaghmi, Amna Ali Alahmed, Mansour Mana Alzamanan, and Ali Hussain Majrashi. "Pethidine-related neurotoxicity in pediatric sickle cell disease: a systematic review." International Journal of Medicine in Developing Countries 7.12 (2023), 1758-1765. Print. doi:10.24911/IJMDC.51-1693034094


APA (American Psychological Association) Style

Almasoud, K. A., Aldaghmi, . A. F., Alahmed, . A. A., Alzamanan, . M. M. & Majrashi, . A. H. (2023) Pethidine-related neurotoxicity in pediatric sickle cell disease: a systematic review. International Journal of Medicine in Developing Countries, 7 (12), 1758-1765. doi:10.24911/IJMDC.51-1693034094




Most Viewed Articles
Most Accessed Articles

  • Marginal adaptation of fixed prosthodontics
    Shahad Mohammed Halawani, Sahar Amer Al-Harbi
    IJMDC. 2017; 1(2): 78-84
    » Abstract » doi: 10.24911/IJMDC.1.2.7

  • Parasites in central nervous system
    Amal Ahmed Mohamed, Asmaa Mohamed Mansour
    IJMDC. 2017; 1(2): 72-77
    » Abstract » doi: 10.24911/IJMDC.1.2.6

  • Non-diabetic retinopathy: a case report
    Hassan F. Alkwikbi, Nabil Mamon Abdelfattah, Haithem Mamon Abdelfattah
    IJMDC. 2017; 1(1): 33-37
    » Abstract » doi: 10.24911/IJMDC.1.1.6

  • Vitamin D deficiency among high school female students in Riyadh
    Sahar Mohsen Aldhafeeri, Fatemah Ibraheem Alrawaji, Abrar Mubarak Algharbi, Alanoud Abdullah Alhessan, Ayat Sami Qabaja, Ghaleah Abdulaziz Alnassar, Ghaliah Ofayn Alsulami, Mashael Belal Alrubaian, Norah Abdulaziz Alhatim, Salehah Salih Alotaibi, Zahra Ali Alkhamees
    IJMDC. 2017; 1(1): 18-23
    » Abstract » doi: 10.24911/IJMDC.1.1.4

  • Prognosis of chronic complications of diabetes mellitus (DM) after multiple events of diabetic ketoacidosis (DKA)
    Baraa Faiez Rajab, Anwar Essa Alamrim, Ali Essa Alamri
    IJMDC. 2019; 3(5): 474-479
    » Abstract » doi: 10.24911/IJMDC.51-1546551993

    •
    Most Downloaded
    Top Downloaded Articles

  • Anti-IL-17 markedly inhibited the in vitro granuloma induced by Schistosoma mansoni soluble egg antigen.
    Asmaa Ezz, Irene S. Gmail, Fatma Elzahraa H. Salem, Rabab Salama, Soad Nady
    IJMDC. 2018; 2(January 2018): 38-46
    » Abstract » doi: 10.24911/IJMDC.2.1.7

  • Vitamin D deficiency among high school female students in Riyadh
    Sahar Mohsen Aldhafeeri, Fatemah Ibraheem Alrawaji, Abrar Mubarak Algharbi, Alanoud Abdullah Alhessan, Ayat Sami Qabaja, Ghaleah Abdulaziz Alnassar, Ghaliah Ofayn Alsulami, Mashael Belal Alrubaian, Norah Abdulaziz Alhatim, Salehah Salih Alotaibi, Zahra Ali Alkhamees
    IJMDC. 2017; 1(1): 18-23
    » Abstract » doi: 10.24911/IJMDC.1.1.4

  • Antibiotic Resistance Crisis
    Nuha Saad Mobarki, Buthaina Abdullah Almerabi, Ahmad Hattan Hattan
    IJMDC. 2019; 3(6): 561-564
    » Abstract » doi: 10.24911/IJMDC.51-1549060699

  • The knowledge of mothers about children malnutrition and associated factors
    Anas Abdulrahman Aljohani, Mujahid Abdulrahman Aljohani
    IJMDC. 2020; 4(1): 7-11
    » Abstract » doi: 10.24911/IJMDC.51-1541620358

  • Knowledge and attitude of caregivers of cerebral palsy children in Riyadh city
    Abdulaziz Alruwaished, Baleegh Ali, Lubna Abdullah Alhowaimil , Abaraa adullah Alhowaimil, Najd Abdullah Alhowaimil, Aminah Alessa
    IJMDC. 2020; 4(1): 12-17
    » Abstract » doi: 10.24911/IJMDC.51-1547833051

    •
    Most Cited Articles
    Most Cited Articles

  • Antibiotic Resistance Crisis
    Nuha Saad Mobarki, Buthaina Abdullah Almerabi, Ahmad Hattan Hattan
    IJMDC. 2019; 3(6): 561-564
    » Abstract » doi: 10.24911/IJMDC.51-1549060699
    Cited : 34 times [Click to see citing articles]

  • Prevalence of depression, anxiety and stress among diabetes mellitus patients in Arar, Northern Saudi Arabia
    AMohammed Elamin Mukrim, Nujud Muteb D. Alshammari, Wurud Muteb D. Alshammari, Maali Subhi T. Alshammari, Yousef Nasif R. Alshammari, Abdulaziz Sael M. Alshammari, Maisa Hamad F. Alanazi, Abdulelah Abdulrhman F. Alzammam, Muharib Mana M. Alshammari, Slwa Khaled Abu Asyah, Aseel Jamal Alzuhayri, Mushref Saeid Alshammari
    IJMDC. 2019; 3(3): 229-233
    » Abstract » doi: 10.24911/IJMDC.51-1542576396
    Cited : 8 times [Click to see citing articles]

  • Knowledge, attitude, and practice of breast self-examination toward breast cancer among female students at King Saud University in Riyadh, Saudi Arabia
    Abdullah Nasser Alomair, Dania Ghazi Felemban, Mohannad Sami Felemban, Jameel Abdullah Awadain, Ammar Saud Altowairqi, Nawaf Fawzan Alfawzan, Fatimah Mohammed Almazayen, Abdulrahman Jalwi Korkoman, Nawaf Saad Alrusayyis
    IJMDC. 2020; 4(2): 429-434
    » Abstract » doi: 10.24911/IJMDC.51-1576668182
    Cited : 8 times [Click to see citing articles]

  • Population awareness about rheumatoid arthritis in Jazan region, Saudi Arabia
    Ahmad Ali Hazzazi, Mohssen Hassen Ageeli, Ahmed Ali Muyidi, Abdulaziz Mohammad Abulgasim, Abdullah Ahmad Yateemi, Nabil Alhakami
    IJMDC. 2020; 4(3): 668-675
    » Abstract » doi: 10.24911/IJMDC.51-1576010943
    Cited : 4 times [Click to see citing articles]

  • Prevalence and factors associated with depression among health care workers in National Guard Hospital in Riyadh, KSA
    Noor Mohammad AlFahhad
    IJMDC. 2018; 2(September 2018): 92-96
    » Abstract » doi: 10.24911/IJMDC.51-1526306040
    Cited : 4 times [Click to see citing articles]

    •

    About International Journal of Medicine in Developing Countries

    International Journal of Medicine in Developing Countries is a peer-reviewed, open access international medical journal. Journal Title Internat ... Read more.



    For best results, please use Internet Explorer or Google Chrome.

    Contact Information

    Publisher: Discover STM Publishing Ltd. 164 Moyville. Rathfarnham, Dublin, D16Y4E, Ireland

    Hours:  M-F: 7:30am - 4:30pm 

    Fax: +353 (0)1 633 5037 

    Emails:

    Journal Editorial Office:  contact@ijmdc.com

    All queries regarding the publishing or accepting of the manuscript should be directed to the Journal Editorial Office at Riyadh, Saudi Arabia. 

    Publishing and Hosting service is provided by Discover STM (Ireland):  contact@discoverpublish.com
    POLICIES & JOURNAL LINKS
    Author Login
    Reviewer Login
    About Publisher
    Advertising Policy
    Author's Rights and Obligations
    Conflict of Interest Policy
    Copyright Information
    Digital Archiving & Preservation Policies
    Editorial Policies
    Peer Review Policy
    Editorial & Peer Review Process
    License Information
    Open Access Policy
    Plagiarism Policy
    Privacy Policy
    Protection of Research Participants (Statement On Human And Animal Rights)
    Publication Ethics and Publication Malpractice Statement
    Corrections, Retractions & Expressions of Concern
    Self-Archiving Policies
    Statement of Informed Consent
    Terms of Use