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2024, Vol: 8, Issue: 4
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Review Article

Online Publishing Date:
21 / 03 / 2023

 


Obesity due to iatrogenic causes in patients with epilepsy: a systematic review

Naif Hadi Ali, Mohammed Majeed A. Alwaily, Asayel Saeed M. Alqahtani, Ali Abdullah A. Businnah, Abdulaziz Ibrahim Alatef, Abdullah Mesfer AL Aldbey.


Abstract
Over the past few years, research has suggested a link between valproate sodium (VPA) therapy and weight gain. This systematic review investigates the association between obesity and VPA treatment in epilepsy patients. PubMed, Web of Science, Science Direct, EBSCO, SCOPUS, Wiley, and Cochrane Library were used to perform a systematic literature search. Study articles were screened by title and abstract using Rayyan QCRI then a full-text assessment was implemented. A total of 9 studies with 416 patients were included. Valproatetreated adult patients for epilepsy experience weight gain up to obesity while undergoing treatment. Studies investigating the pediatric population reported that obesity in children receiving VPA is widespread. Treatment with VPA is associated with a significant weight gain and related metabolic disorders in adults and children with
epilepsy. Leptin and insulin resistance are suggested as the primary mechanisms underlying weight gain with VPA, despite the need for extensive research into the mechanisms underlying their development in patients taking the medication.

Key words: Obesity, weight gain, epilepsy, valproate, systematic review.


 
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How to Cite this Article
Pubmed Style

Ali NH, Alwaily MMA, Alqahtani ASM, Businnah AAA, Alatef AI, Aldbey AMA. Obesity due to iatrogenic causes in patients with epilepsy: a systematic review. IJMDC. 2023; 7(7): 1034-1040. doi:10.24911/IJMDC.51-1675505374

Web Style

Ali NH, Alwaily MMA, Alqahtani ASM, Businnah AAA, Alatef AI, Aldbey AMA. Obesity due to iatrogenic causes in patients with epilepsy: a systematic review. https://www.ijmdc.com/?mno=142823 [Access: March 28, 2024]. doi:10.24911/IJMDC.51-1675505374

AMA (American Medical Association) Style

Ali NH, Alwaily MMA, Alqahtani ASM, Businnah AAA, Alatef AI, Aldbey AMA. Obesity due to iatrogenic causes in patients with epilepsy: a systematic review. IJMDC. 2023; 7(7): 1034-1040. doi:10.24911/IJMDC.51-1675505374


Vancouver/ICMJE Style

Ali NH, Alwaily MMA, Alqahtani ASM, Businnah AAA, Alatef AI, Aldbey AMA. Obesity due to iatrogenic causes in patients with epilepsy: a systematic review. IJMDC. (2023), [cited March 28, 2024]; 7(7): 1034-1040. doi:10.24911/IJMDC.51-1675505374


Harvard Style

Ali, N. H., Alwaily, . M. M. A., Alqahtani, . A. S. M., Businnah, . A. A. A., Alatef, . A. I. & Aldbey, . A. M. A. (2023) Obesity due to iatrogenic causes in patients with epilepsy: a systematic review. IJMDC, 7 (7), 1034-1040. doi:10.24911/IJMDC.51-1675505374


Turabian Style

Ali, Naif Hadi, Mohammed Majeed A. Alwaily, Asayel Saeed M. Alqahtani, Ali Abdullah A. Businnah, Abdulaziz Ibrahim Alatef, and Abdullah Mesfer AL Aldbey. 2023. Obesity due to iatrogenic causes in patients with epilepsy: a systematic review. International Journal of Medicine in Developing Countries, 7 (7), 1034-1040. doi:10.24911/IJMDC.51-1675505374


Chicago Style

Ali, Naif Hadi, Mohammed Majeed A. Alwaily, Asayel Saeed M. Alqahtani, Ali Abdullah A. Businnah, Abdulaziz Ibrahim Alatef, and Abdullah Mesfer AL Aldbey. "Obesity due to iatrogenic causes in patients with epilepsy: a systematic review." International Journal of Medicine in Developing Countries 7 (2023), 1034-1040. doi:10.24911/IJMDC.51-1675505374


MLA (The Modern Language Association) Style

Ali, Naif Hadi, Mohammed Majeed A. Alwaily, Asayel Saeed M. Alqahtani, Ali Abdullah A. Businnah, Abdulaziz Ibrahim Alatef, and Abdullah Mesfer AL Aldbey. "Obesity due to iatrogenic causes in patients with epilepsy: a systematic review." International Journal of Medicine in Developing Countries 7.7 (2023), 1034-1040. Print. doi:10.24911/IJMDC.51-1675505374


APA (American Psychological Association) Style

Ali, N. H., Alwaily, . M. M. A., Alqahtani, . A. S. M., Businnah, . A. A. A., Alatef, . A. I. & Aldbey, . A. M. A. (2023) Obesity due to iatrogenic causes in patients with epilepsy: a systematic review. International Journal of Medicine in Developing Countries, 7 (7), 1034-1040. doi:10.24911/IJMDC.51-1675505374




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