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Review Article

IJMDC. 2022; 6(5): 740-747

Cyclophosphamide related toxicity; a systematic review

Authors: Ahmed Eissa Alrefaei, Meshael Ahmed Alzahrani, Sultan Abdulrahman Alsuhaim.

ABSTRACT

Cyclophosphamide is an alkylating agent that has been used for the treatment of severe manifestations of autoimmune inflammatory disease. Cyclophosphamide is widely used for the treatment of malignancies; it exerts its impact through the cessation of cell division. Cyclophosphamide is similar to other chemotherapies and has various toxicities; however, its toxicity is not well reported. This review was conducted to find out cyclophosphamide-related toxicities as reported in the previous studies conducted on that subject. A total of 91 articles were obtained, but only six studies were eligible for the inclusion criteria. The studies included a total number of 3,531 participants. Cyclophosphamide was associated with various toxicities, including liver toxicity, urotoxicity, cardiac toxicity, hematological, and non-hematological toxicities. The toxicity of cyclophosphamide varied based on the regimen and combined medications, as well as some gene variants.

Keywords:
Cyclophosphamide, Toxicity, Predictors, Outcomes

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Cyclophosphamide related toxicity; a systematic review

Authors
Ahmed Eissa Alrefaei
Pharmacy Department, Alhada Armed Forces Hospital, Taif, Saudi Arabia
PubMed articles Google scholar articles

Meshael Ahmed Alzahrani
Pharmacy Department, Alhada Armed Forces Hospital, Taif, Saudi Arabia
PubMed articles Google scholar articles

Sultan Abdulrahman Alsuhaim
Pharmacy Department, Alhada Armed Forces Hospital, Taif, Saudi Arabia.
PubMed articles Google scholar articles

Correspondence to:
. Pharmacy Department, Alhada Armed Forces Hospital, Taif, Saudi Arabia.; a.alrefaei2018@gmail.com

Publication history
Received 03 Jan 2022
Accepted 09 Jan 2022
Published online 16 Jan 2022
Published in print 11 Apr 2022

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Pubmed Style

Alrefaei AE, Alzahrani MA, Alsuhaim SA. Cyclophosphamide related toxicity; a systematic review. IJMDC. 2022; 6(5): 740-747. doi:10.24911/IJMDC.51-1641243189

Web Style

Alrefaei AE, Alzahrani MA, Alsuhaim SA. Cyclophosphamide related toxicity; a systematic review. https://www.ijmdc.com/?mno=140403 [Access: July 03, 2022]. doi:10.24911/IJMDC.51-1641243189

AMA (American Medical Association) Style

Alrefaei AE, Alzahrani MA, Alsuhaim SA. Cyclophosphamide related toxicity; a systematic review. IJMDC. 2022; 6(5): 740-747. doi:10.24911/IJMDC.51-1641243189

Vancouver/ICMJE Style

Alrefaei AE, Alzahrani MA, Alsuhaim SA. Cyclophosphamide related toxicity; a systematic review. IJMDC. (2022), [cited July 03, 2022]; 6(5): 740-747. doi:10.24911/IJMDC.51-1641243189

Harvard Style

Alrefaei, A. E., Alzahrani, . M. A. & Alsuhaim, . S. A. (2022) Cyclophosphamide related toxicity; a systematic review. IJMDC, 6 (5), 740-747. doi:10.24911/IJMDC.51-1641243189

Turabian Style

Alrefaei, Ahmed Eissa, Meshael Ahmed Alzahrani, and Sultan Abdulrahman Alsuhaim. 2022. Cyclophosphamide related toxicity; a systematic review. International Journal of Medicine in Developing Countries, 6 (5), 740-747. doi:10.24911/IJMDC.51-1641243189

Chicago Style

Alrefaei, Ahmed Eissa, Meshael Ahmed Alzahrani, and Sultan Abdulrahman Alsuhaim. "Cyclophosphamide related toxicity; a systematic review." International Journal of Medicine in Developing Countries 6 (2022), 740-747. doi:10.24911/IJMDC.51-1641243189

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Alrefaei, A. E., Alzahrani, . M. A. & Alsuhaim, . S. A. (2022) Cyclophosphamide related toxicity; a systematic review. International Journal of Medicine in Developing Countries, 6 (5), 740-747. doi:10.24911/IJMDC.51-1641243189

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International Journal of Medicine in Developing Countries