IJMDC. 2023; 7(4): 727-731

A study of the clinical toxicity of methotrexate in the Taif region: a case report

Authors: Khalid M. Alhusayni, Ibrahim M. Alanazi, Ibrahim M. Dighriri, Ahmed T. Alnazzawi, Ozoof A. Rashed, Faisal M. Alharthi, Fawaz M. Mashi, Nabeel A. Ogdy, Mohammed T. Sulimani, Mohammad S. Alzahrani, Mohannd A. Alghamdi, Sami A. Almalki, Khalid M. Alzaidi, Ghadi I. Alqurashi, Fahad S. Alqurashi.

ABSTRACT

Background: The first report, written by Sidney Farber in 1948, detailed his success in the use of methotrexate (MTX) for the treatment of leukemia in children. The drug was used for the first time in 1951 for the treatment of rheumatoid arthritis and psoriasis. MTX classical antifolate, also known as amethopterin, is 4-amino-4- dcoxy-Na-methyl folic acid. The correlation between toxic reactions and the pharmacokinetics of MTX discloses certain time- and concentration-dependent relationships that appear to determine which target tissue is at risk for toxicity, whether toxicity will occur and the severity of MTX toxicity. A high dose of MTX (HDMTX) is defined as more than 500 mg/m2 or if given intravenously. Case Presentation: HDMTX can cause significant toxicity, including myelosuppression, mucositis, hepatotoxicity and, in severe cases, may cause multiorgan failure. Conclusion: An early understanding of the causes and risk factors for MTX toxicity may be beneficial in reducing the occurrence of MTX toxicity in the Taif region.

Keywords:
Methotrexte, toxicity, high dose, hepatotoxicity, rheumatoid arthritis.


';
A study of the clinical toxicity of methotrexate in the Taif region: a case report


Authors
Khalid M Alhusayni
Department of Pharmacy, King Abdulaziz Specialist Hospital, Taif, Saudi Arabia
PubMed articlesGoogle scholar articles

Ibrahim M Alanazi
Department of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia
PubMed articlesGoogle scholar articles

Ibrahim M Dighriri
Department of Pharmacy, King Abdulaziz Specialist Hospital, Taif, Saudi Arabia
PubMed articlesGoogle scholar articles

Ahmed T Alnazzawi
Department of Pharmacy, King Faisal Hospital, Makkah, Saudi Arabia
PubMed articlesGoogle scholar articles

Ozoof A Rashed
Department of Pharmacy, King Faisal Hospital, Makkah, Saudi Arabia
PubMed articlesGoogle scholar articles

Faisal M Alharthi
Department of Pharmacy, King Faisal Hospital, Makkah, Saudi Arabia
PubMed articlesGoogle scholar articles

Fawaz M Mashi
Department of Pharmacy, King Fahad Central Hospital, Jazan, Saudi Arabia
PubMed articlesGoogle scholar articles

Nabeel A Ogdy
Department of Pharmacy, King Fahad Central Hospital, Jazan, Saudi Arabia
PubMed articlesGoogle scholar articles

Mohammed T Sulimani
Department of Pharmacy, King Abdulaziz Specialist Hospital, Taif, Saudi Arabia
PubMed articlesGoogle scholar articles

Mohammad S Alzahrani
Eradah and Mental Health Complex Pharmacy, Taif, Saudi Arabia
PubMed articlesGoogle scholar articles

Mohannd A Alghamdi
Obligation Department of the MOH, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles

Sami A Almalki
Department of Pharmacy, Ajyad Hospital, Makkah, Saudi Arabia
PubMed articlesGoogle scholar articles

Khalid M Alzaidi
Department of Pharmacy, King Abdulaziz Specialist Hospital, Taif, Saudi Arabia
PubMed articlesGoogle scholar articles

Ghadi I Alqurashi
Department of Pharmacy, King Abdulaziz Specialist Hospital, Taif, Saudi Arabia
PubMed articlesGoogle scholar articles

Fahad S Alqurashi
Department of Pharmacy, King Abdulaziz Specialist Hospital, Taif, Saudi Arabia.
PubMed articlesGoogle scholar articles


Correspondence to:
. Khalid Mohammed Alhusayni, Department of Pharmacy, King Abdulaziz Hospital,Taif city, Saudi Arabia.; khaled_2080@hotmail.com

Publication history
Received 15 Nov 2022
Accepted 28 Dec 2022
Published online 02 Jan 2023
Published in print 15 Jan 2023

How to cite this article?

Export to EndNote Export to refMan

Pubmed Style

Alhusayni KM, Alanazi IM, Dighriri IM, Alnazzawi AT, Rashed OA, Alharthi FM, Mashi FM, Ogdy NA, Sulimani MT, Alzahrani MS, Alghamdi MA, Almalki SA, Alzaidi KM, Alqurashi GI, Alqurashi FS. A study of the clinical toxicity of methotrexate in the Taif region: a case report. IJMDC. 2023; 7(4): 727-731. doi:10.24911/IJMDC.51-1668495868


Web Style

Alhusayni KM, Alanazi IM, Dighriri IM, Alnazzawi AT, Rashed OA, Alharthi FM, Mashi FM, Ogdy NA, Sulimani MT, Alzahrani MS, Alghamdi MA, Almalki SA, Alzaidi KM, Alqurashi GI, Alqurashi FS. A study of the clinical toxicity of methotrexate in the Taif region: a case report. https://www.ijmdc.com/?mno=129882 [Access: March 22, 2023]. doi:10.24911/IJMDC.51-1668495868


AMA (American Medical Association) Style

Alhusayni KM, Alanazi IM, Dighriri IM, Alnazzawi AT, Rashed OA, Alharthi FM, Mashi FM, Ogdy NA, Sulimani MT, Alzahrani MS, Alghamdi MA, Almalki SA, Alzaidi KM, Alqurashi GI, Alqurashi FS. A study of the clinical toxicity of methotrexate in the Taif region: a case report. IJMDC. 2023; 7(4): 727-731. doi:10.24911/IJMDC.51-1668495868


Vancouver/ICMJE Style

Alhusayni KM, Alanazi IM, Dighriri IM, Alnazzawi AT, Rashed OA, Alharthi FM, Mashi FM, Ogdy NA, Sulimani MT, Alzahrani MS, Alghamdi MA, Almalki SA, Alzaidi KM, Alqurashi GI, Alqurashi FS. A study of the clinical toxicity of methotrexate in the Taif region: a case report. IJMDC. (2023), [cited March 22, 2023]; 7(4): 727-731. doi:10.24911/IJMDC.51-1668495868


Harvard Style

Alhusayni, K. M., Alanazi, . I. M., Dighriri, . I. M., Alnazzawi, . A. T., Rashed, . O. A., Alharthi, . F. M., Mashi, . F. M., Ogdy, . N. A., Sulimani, . M. T., Alzahrani, . M. S., Alghamdi, . M. A., Almalki, . S. A., Alzaidi, . K. M., Alqurashi, . G. I. & Alqurashi, . F. S. (2023) A study of the clinical toxicity of methotrexate in the Taif region: a case report. IJMDC, 7 (4), 727-731. doi:10.24911/IJMDC.51-1668495868


Turabian Style

Alhusayni, Khalid M., Ibrahim M. Alanazi, Ibrahim M. Dighriri, Ahmed T. Alnazzawi, Ozoof A. Rashed, Faisal M. Alharthi, Fawaz M. Mashi, Nabeel A. Ogdy, Mohammed T. Sulimani, Mohammad S. Alzahrani, Mohannd A. Alghamdi, Sami A. Almalki, Khalid M. Alzaidi, Ghadi I. Alqurashi, and Fahad S. Alqurashi. 2023. A study of the clinical toxicity of methotrexate in the Taif region: a case report. International Journal of Medicine in Developing Countries, 7 (4), 727-731. doi:10.24911/IJMDC.51-1668495868


Chicago Style

Alhusayni, Khalid M., Ibrahim M. Alanazi, Ibrahim M. Dighriri, Ahmed T. Alnazzawi, Ozoof A. Rashed, Faisal M. Alharthi, Fawaz M. Mashi, Nabeel A. Ogdy, Mohammed T. Sulimani, Mohammad S. Alzahrani, Mohannd A. Alghamdi, Sami A. Almalki, Khalid M. Alzaidi, Ghadi I. Alqurashi, and Fahad S. Alqurashi. "A study of the clinical toxicity of methotrexate in the Taif region: a case report." International Journal of Medicine in Developing Countries 7 (2023), 727-731. doi:10.24911/IJMDC.51-1668495868


MLA (The Modern Language Association) Style

Alhusayni, Khalid M., Ibrahim M. Alanazi, Ibrahim M. Dighriri, Ahmed T. Alnazzawi, Ozoof A. Rashed, Faisal M. Alharthi, Fawaz M. Mashi, Nabeel A. Ogdy, Mohammed T. Sulimani, Mohammad S. Alzahrani, Mohannd A. Alghamdi, Sami A. Almalki, Khalid M. Alzaidi, Ghadi I. Alqurashi, and Fahad S. Alqurashi. "A study of the clinical toxicity of methotrexate in the Taif region: a case report." International Journal of Medicine in Developing Countries 7.4 (2023), 727-731. Print. doi:10.24911/IJMDC.51-1668495868


APA (American Psychological Association) Style

Alhusayni, K. M., Alanazi, . I. M., Dighriri, . I. M., Alnazzawi, . A. T., Rashed, . O. A., Alharthi, . F. M., Mashi, . F. M., Ogdy, . N. A., Sulimani, . M. T., Alzahrani, . M. S., Alghamdi, . M. A., Almalki, . S. A., Alzaidi, . K. M., Alqurashi, . G. I. & Alqurashi, . F. S. (2023) A study of the clinical toxicity of methotrexate in the Taif region: a case report. International Journal of Medicine in Developing Countries, 7 (4), 727-731. doi:10.24911/IJMDC.51-1668495868


Share this article

Click the icon of the social media platform on which you would like to share this article.

Article Statistics

Request permissions

If you wish to reuse any part or all of this article please contact the copyright holder, contact@ijmdc.com.

Copyright ©2023 Discover STM Publishing. All Rights Reserved.