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Case Report
Online Published: 02 Jan 2023
 


A study of the clinical toxicity of methotrexate in the Taif region: a case report

Khalid M. Alhusayni, Ibrahim M. Alanazi, Ibrahim M. Dighriri, Ahmed T. Alnazzawi, Ozoof A. Rashed, Faisal M. Alharthi, Fawaz M. Mashi, Nabeel A. Ogdy, Mohammed T. Sulimani, Mohammad S. Alzahrani, Mohannd A. Alghamdi, Sami A. Almalki, Khalid M. Alzaidi, Ghadi I. Alqurashi, Fahad S. Alqurashi.


Abstract
Background: The first report, written by Sidney Farber in 1948, detailed his success in the use of methotrexate (MTX) for the treatment of leukemia in children. The drug was used for the first time in 1951 for the treatment of rheumatoid arthritis and psoriasis. MTX classical antifolate, also known as amethopterin, is 4-amino-4- dcoxy-Na-methyl folic acid. The correlation between toxic reactions and the pharmacokinetics of MTX discloses certain time- and concentration-dependent relationships that appear to determine which target tissue is at risk for toxicity, whether toxicity will occur and the severity of MTX toxicity. A high dose of MTX (HDMTX) is defined as more than 500 mg/m2 or if given intravenously.
Case Presentation: HDMTX can cause significant toxicity, including myelosuppression, mucositis, hepatotoxicity and, in severe cases, may cause multiorgan failure.
Conclusion: An early understanding of the causes and risk factors for MTX toxicity may be beneficial in reducing the occurrence of MTX toxicity in the Taif region.

Key words: Methotrexte, toxicity, high dose, hepatotoxicity, rheumatoid arthritis.


 
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How to Cite this Article
Pubmed Style

Alhusayni KM, Alanazi IM, Dighriri IM, Alnazzawi AT, Rashed OA, Alharthi FM, Mashi FM, Ogdy NA, Sulimani MT, Alzahrani MS, Alghamdi MA, Almalki SA, Alzaidi KM, Alqurashi GI, Alqurashi FS. A study of the clinical toxicity of methotrexate in the Taif region: a case report. IJMDC. 2023; 7(4): 727-731. doi:10.24911/IJMDC.51-1668495868

Web Style

Alhusayni KM, Alanazi IM, Dighriri IM, Alnazzawi AT, Rashed OA, Alharthi FM, Mashi FM, Ogdy NA, Sulimani MT, Alzahrani MS, Alghamdi MA, Almalki SA, Alzaidi KM, Alqurashi GI, Alqurashi FS. A study of the clinical toxicity of methotrexate in the Taif region: a case report. https://www.ijmdc.com/?mno=129882 [Access: April 23, 2025]. doi:10.24911/IJMDC.51-1668495868

AMA (American Medical Association) Style

Alhusayni KM, Alanazi IM, Dighriri IM, Alnazzawi AT, Rashed OA, Alharthi FM, Mashi FM, Ogdy NA, Sulimani MT, Alzahrani MS, Alghamdi MA, Almalki SA, Alzaidi KM, Alqurashi GI, Alqurashi FS. A study of the clinical toxicity of methotrexate in the Taif region: a case report. IJMDC. 2023; 7(4): 727-731. doi:10.24911/IJMDC.51-1668495868


Vancouver/ICMJE Style

Alhusayni KM, Alanazi IM, Dighriri IM, Alnazzawi AT, Rashed OA, Alharthi FM, Mashi FM, Ogdy NA, Sulimani MT, Alzahrani MS, Alghamdi MA, Almalki SA, Alzaidi KM, Alqurashi GI, Alqurashi FS. A study of the clinical toxicity of methotrexate in the Taif region: a case report. IJMDC. (2023), [cited April 23, 2025]; 7(4): 727-731. doi:10.24911/IJMDC.51-1668495868


Harvard Style

Alhusayni, K. M., Alanazi, . I. M., Dighriri, . I. M., Alnazzawi, . A. T., Rashed, . O. A., Alharthi, . F. M., Mashi, . F. M., Ogdy, . N. A., Sulimani, . M. T., Alzahrani, . M. S., Alghamdi, . M. A., Almalki, . S. A., Alzaidi, . K. M., Alqurashi, . G. I. & Alqurashi, . F. S. (2023) A study of the clinical toxicity of methotrexate in the Taif region: a case report. IJMDC, 7 (4), 727-731. doi:10.24911/IJMDC.51-1668495868


Turabian Style

Alhusayni, Khalid M., Ibrahim M. Alanazi, Ibrahim M. Dighriri, Ahmed T. Alnazzawi, Ozoof A. Rashed, Faisal M. Alharthi, Fawaz M. Mashi, Nabeel A. Ogdy, Mohammed T. Sulimani, Mohammad S. Alzahrani, Mohannd A. Alghamdi, Sami A. Almalki, Khalid M. Alzaidi, Ghadi I. Alqurashi, and Fahad S. Alqurashi. 2023. A study of the clinical toxicity of methotrexate in the Taif region: a case report. International Journal of Medicine in Developing Countries, 7 (4), 727-731. doi:10.24911/IJMDC.51-1668495868


Chicago Style

Alhusayni, Khalid M., Ibrahim M. Alanazi, Ibrahim M. Dighriri, Ahmed T. Alnazzawi, Ozoof A. Rashed, Faisal M. Alharthi, Fawaz M. Mashi, Nabeel A. Ogdy, Mohammed T. Sulimani, Mohammad S. Alzahrani, Mohannd A. Alghamdi, Sami A. Almalki, Khalid M. Alzaidi, Ghadi I. Alqurashi, and Fahad S. Alqurashi. "A study of the clinical toxicity of methotrexate in the Taif region: a case report." International Journal of Medicine in Developing Countries 7 (2023), 727-731. doi:10.24911/IJMDC.51-1668495868


MLA (The Modern Language Association) Style

Alhusayni, Khalid M., Ibrahim M. Alanazi, Ibrahim M. Dighriri, Ahmed T. Alnazzawi, Ozoof A. Rashed, Faisal M. Alharthi, Fawaz M. Mashi, Nabeel A. Ogdy, Mohammed T. Sulimani, Mohammad S. Alzahrani, Mohannd A. Alghamdi, Sami A. Almalki, Khalid M. Alzaidi, Ghadi I. Alqurashi, and Fahad S. Alqurashi. "A study of the clinical toxicity of methotrexate in the Taif region: a case report." International Journal of Medicine in Developing Countries 7.4 (2023), 727-731. Print. doi:10.24911/IJMDC.51-1668495868


APA (American Psychological Association) Style

Alhusayni, K. M., Alanazi, . I. M., Dighriri, . I. M., Alnazzawi, . A. T., Rashed, . O. A., Alharthi, . F. M., Mashi, . F. M., Ogdy, . N. A., Sulimani, . M. T., Alzahrani, . M. S., Alghamdi, . M. A., Almalki, . S. A., Alzaidi, . K. M., Alqurashi, . G. I. & Alqurashi, . F. S. (2023) A study of the clinical toxicity of methotrexate in the Taif region: a case report. International Journal of Medicine in Developing Countries, 7 (4), 727-731. doi:10.24911/IJMDC.51-1668495868




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