Case Report
IJMDC. 2023; 7(4): 727-731
A study of the clinical toxicity of methotrexate in the Taif region: a case report
Authors: Khalid M. Alhusayni, Ibrahim M. Alanazi, Ibrahim M. Dighriri, Ahmed T. Alnazzawi, Ozoof A. Rashed, Faisal M. Alharthi, Fawaz M. Mashi, Nabeel A. Ogdy, Mohammed T. Sulimani, Mohammad S. Alzahrani, Mohannd A. Alghamdi, Sami A. Almalki, Khalid M. Alzaidi, Ghadi I. Alqurashi, Fahad S. Alqurashi.
ABSTRACT
Background: The first report, written by Sidney Farber in 1948, detailed his success in the use of methotrexate (MTX) for the treatment of leukemia in children. The drug was used for the first time in 1951 for the treatment of rheumatoid arthritis and psoriasis. MTX classical antifolate, also known as amethopterin, is 4-amino-4- dcoxy-Na-methyl folic acid. The correlation between toxic reactions and the pharmacokinetics of MTX discloses certain time- and concentration-dependent relationships that appear to determine which target tissue is at risk for toxicity, whether toxicity will occur and the severity of MTX toxicity. A high dose of MTX (HDMTX) is defined as more than 500 mg/m2 or if given intravenously. Case Presentation: HDMTX can cause significant toxicity, including myelosuppression, mucositis, hepatotoxicity and, in severe cases, may cause multiorgan failure. Conclusion: An early understanding of the causes and risk factors for MTX toxicity may be beneficial in reducing the occurrence of MTX toxicity in the Taif region.
Keywords:
Methotrexte, toxicity, high dose, hepatotoxicity, rheumatoid arthritis.
Authors
Khalid M Alhusayni
Department of Pharmacy, King Abdulaziz Specialist Hospital, Taif, Saudi Arabia
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Ibrahim M Alanazi
Department of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia
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Ibrahim M Dighriri
Department of Pharmacy, King Abdulaziz Specialist Hospital, Taif, Saudi Arabia
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Ahmed T Alnazzawi
Department of Pharmacy, King Faisal Hospital, Makkah, Saudi Arabia
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Ozoof A Rashed
Department of Pharmacy, King Faisal Hospital, Makkah, Saudi Arabia
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Faisal M Alharthi
Department of Pharmacy, King Faisal Hospital, Makkah, Saudi Arabia
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Fawaz M Mashi
Department of Pharmacy, King Fahad Central Hospital, Jazan, Saudi Arabia
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Nabeel A Ogdy
Department of Pharmacy, King Fahad Central Hospital, Jazan, Saudi Arabia
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Mohammed T Sulimani
Department of Pharmacy, King Abdulaziz Specialist Hospital, Taif, Saudi Arabia
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Mohammad S Alzahrani
Eradah and Mental Health Complex Pharmacy, Taif, Saudi Arabia
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Mohannd A Alghamdi
Obligation Department of the MOH, Jeddah, Saudi Arabia
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Sami A Almalki
Department of Pharmacy, Ajyad Hospital, Makkah, Saudi Arabia
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Khalid M Alzaidi
Department of Pharmacy, King Abdulaziz Specialist Hospital, Taif, Saudi Arabia
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Ghadi I Alqurashi
Department of Pharmacy, King Abdulaziz Specialist Hospital, Taif, Saudi Arabia
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Fahad S Alqurashi
Department of Pharmacy, King Abdulaziz Specialist Hospital, Taif, Saudi Arabia.
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Correspondence to:
. Khalid Mohammed Alhusayni, Department of Pharmacy, King Abdulaziz Hospital,Taif city, Saudi Arabia.; khaled_2080@hotmail.com
Publication history
Received 15 Nov 2022
Accepted 28 Dec 2022
Published online 02 Jan 2023
Published in print 15 Jan 2023
How to cite this article?
Export to EndNote Export to refManPubmed Style
Alhusayni KM, Alanazi IM, Dighriri IM, Alnazzawi AT, Rashed OA, Alharthi FM, Mashi FM, Ogdy NA, Sulimani MT, Alzahrani MS, Alghamdi MA, Almalki SA, Alzaidi KM, Alqurashi GI, Alqurashi FS. A study of the clinical toxicity of methotrexate in the Taif region: a case report. IJMDC. 2023; 7(4): 727-731. doi:10.24911/IJMDC.51-1668495868
Web Style
Alhusayni KM, Alanazi IM, Dighriri IM, Alnazzawi AT, Rashed OA, Alharthi FM, Mashi FM, Ogdy NA, Sulimani MT, Alzahrani MS, Alghamdi MA, Almalki SA, Alzaidi KM, Alqurashi GI, Alqurashi FS. A study of the clinical toxicity of methotrexate in the Taif region: a case report. https://www.ijmdc.com/?mno=129882 [Access: March 22, 2023]. doi:10.24911/IJMDC.51-1668495868
AMA (American Medical Association) Style
Alhusayni KM, Alanazi IM, Dighriri IM, Alnazzawi AT, Rashed OA, Alharthi FM, Mashi FM, Ogdy NA, Sulimani MT, Alzahrani MS, Alghamdi MA, Almalki SA, Alzaidi KM, Alqurashi GI, Alqurashi FS. A study of the clinical toxicity of methotrexate in the Taif region: a case report. IJMDC. 2023; 7(4): 727-731. doi:10.24911/IJMDC.51-1668495868
Vancouver/ICMJE Style
Alhusayni KM, Alanazi IM, Dighriri IM, Alnazzawi AT, Rashed OA, Alharthi FM, Mashi FM, Ogdy NA, Sulimani MT, Alzahrani MS, Alghamdi MA, Almalki SA, Alzaidi KM, Alqurashi GI, Alqurashi FS. A study of the clinical toxicity of methotrexate in the Taif region: a case report. IJMDC. (2023), [cited March 22, 2023]; 7(4): 727-731. doi:10.24911/IJMDC.51-1668495868
Harvard Style
Alhusayni, K. M., Alanazi, . I. M., Dighriri, . I. M., Alnazzawi, . A. T., Rashed, . O. A., Alharthi, . F. M., Mashi, . F. M., Ogdy, . N. A., Sulimani, . M. T., Alzahrani, . M. S., Alghamdi, . M. A., Almalki, . S. A., Alzaidi, . K. M., Alqurashi, . G. I. & Alqurashi, . F. S. (2023) A study of the clinical toxicity of methotrexate in the Taif region: a case report. IJMDC, 7 (4), 727-731. doi:10.24911/IJMDC.51-1668495868
Turabian Style
Alhusayni, Khalid M., Ibrahim M. Alanazi, Ibrahim M. Dighriri, Ahmed T. Alnazzawi, Ozoof A. Rashed, Faisal M. Alharthi, Fawaz M. Mashi, Nabeel A. Ogdy, Mohammed T. Sulimani, Mohammad S. Alzahrani, Mohannd A. Alghamdi, Sami A. Almalki, Khalid M. Alzaidi, Ghadi I. Alqurashi, and Fahad S. Alqurashi. 2023. A study of the clinical toxicity of methotrexate in the Taif region: a case report. International Journal of Medicine in Developing Countries, 7 (4), 727-731. doi:10.24911/IJMDC.51-1668495868
Chicago Style
Alhusayni, Khalid M., Ibrahim M. Alanazi, Ibrahim M. Dighriri, Ahmed T. Alnazzawi, Ozoof A. Rashed, Faisal M. Alharthi, Fawaz M. Mashi, Nabeel A. Ogdy, Mohammed T. Sulimani, Mohammad S. Alzahrani, Mohannd A. Alghamdi, Sami A. Almalki, Khalid M. Alzaidi, Ghadi I. Alqurashi, and Fahad S. Alqurashi. "A study of the clinical toxicity of methotrexate in the Taif region: a case report." International Journal of Medicine in Developing Countries 7 (2023), 727-731. doi:10.24911/IJMDC.51-1668495868
MLA (The Modern Language Association) Style
Alhusayni, Khalid M., Ibrahim M. Alanazi, Ibrahim M. Dighriri, Ahmed T. Alnazzawi, Ozoof A. Rashed, Faisal M. Alharthi, Fawaz M. Mashi, Nabeel A. Ogdy, Mohammed T. Sulimani, Mohammad S. Alzahrani, Mohannd A. Alghamdi, Sami A. Almalki, Khalid M. Alzaidi, Ghadi I. Alqurashi, and Fahad S. Alqurashi. "A study of the clinical toxicity of methotrexate in the Taif region: a case report." International Journal of Medicine in Developing Countries 7.4 (2023), 727-731. Print. doi:10.24911/IJMDC.51-1668495868
APA (American Psychological Association) Style
Alhusayni, K. M., Alanazi, . I. M., Dighriri, . I. M., Alnazzawi, . A. T., Rashed, . O. A., Alharthi, . F. M., Mashi, . F. M., Ogdy, . N. A., Sulimani, . M. T., Alzahrani, . M. S., Alghamdi, . M. A., Almalki, . S. A., Alzaidi, . K. M., Alqurashi, . G. I. & Alqurashi, . F. S. (2023) A study of the clinical toxicity of methotrexate in the Taif region: a case report. International Journal of Medicine in Developing Countries, 7 (4), 727-731. doi:10.24911/IJMDC.51-1668495868
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