IJMDC. 2020; 4(11): 1980-1983

Role of serotonin reuptake inhibitor (SSRI) therapies as a therapeutic option for irritable bowel syndrome: a brief review

Authors: Ibrahim Mahmoud Ajwah, Waad Maher Alqulayti, Maram Salim Algrani, Maryam Talal Altuwayjiri, Sahar Yahya S Alatawi, Yazeed Saeed M Alqahtani, Razan Kamel Albalawi, Hadeel Ahmed Almutairi, Yassmeen Hmoud Alblowi, Alaa Sulaiman Almehmadi, Muflih Abdullah Saed Albalawi, Abdulmajeed Faisal A Albalawi, Waleed Khaled Alshehri, Maram Ali Jarallah, Wejdan Saleem Aljohani, Rama Osama Abu Alez.

ABSTRACT

Psychological factors are considered very important to be associated with the development of irritable bowel syndrome (IBS). Trials were suggesting that antidepressant therapy may be useful for patients for symptomatic relief in IBS patients. This study is aimed to summarize the role of selective serotonin reuptake inhibitor (SSRI) therapies for IBS. PubMed, Google Scholar, and EBSCO databases were used to systematically search for relevant articles. The terms ďantidepressant, functional bowel disorders, and irritable bowel syndromeę were used. Among 107 articles, six randomized controlled trials fulfilled the inclusion criteria. In these studies, the efficacy of selective SSRIs was analyzed in IBS. Different interventions were used although, in most studies, their effect on IBSís global symptom relief as a primary outcome was investigated. In IBS patients, SSRI was proven to be effective in pain-relieving and symptom improvement. Although clinical practice guidelines suggest the use of SSRI, clinicians should also consider patientsí acceptance for it.

Keywords:
Functional bowel disorders, systematic review, therapies


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Role of serotonin reuptake inhibitor (SSRI) therapies as a therapeutic option for irritable bowel syndrome: a brief review


Authors
Ibrahim Mahmoud Ajwah
King Salman Armed Forces Hospital, Tabuk, Saudi Arabia
PubMed articlesGoogle scholar articles

Waad Maher Alqulayti
National Guard Hospital, King Abdulaziz Medical City, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles

Maram Salim Algrani
University of Tabuk, Tabuk, Saudi Arabia
PubMed articlesGoogle scholar articles

Maryam Talal Altuwayjiri
University of Tabuk, Tabuk, Saudi Arabia
PubMed articlesGoogle scholar articles

Sahar Yahya S Alatawi
University of Tabuk, Tabuk, Saudi Arabia
PubMed articlesGoogle scholar articles

Yazeed Saeed M Alqahtani
University of Tabuk, Tabuk, Saudi Arabia
PubMed articlesGoogle scholar articles

Razan Kamel Albalawi
University of Tabuk, Tabuk, Saudi Arabia
PubMed articlesGoogle scholar articles

Hadeel Ahmed Almutairi
University of Tabuk, Tabuk, Saudi Arabia
PubMed articlesGoogle scholar articles

Yassmeen Hmoud Alblowi
University of Tabuk, Tabuk, Saudi Arabia
PubMed articlesGoogle scholar articles

Alaa Sulaiman Almehmadi
University of Tabuk, Tabuk, Saudi Arabia
PubMed articlesGoogle scholar articles

Muflih Abdullah Saed Albalawi
University of Tabuk, Tabuk, Saudi Arabia
PubMed articlesGoogle scholar articles

Abdulmajeed Faisal A Albalawi
University of Tabuk, Tabuk, Saudi Arabia
PubMed articlesGoogle scholar articles

Waleed Khaled Alshehri
University of Tabuk, Tabuk, Saudi Arabia
PubMed articlesGoogle scholar articles

Maram Ali Jarallah
University of Tabuk, Tabuk, Saudi Arabia
PubMed articlesGoogle scholar articles

Wejdan Saleem Aljohani
University of Tabuk, Tabuk, Saudi Arabia
PubMed articlesGoogle scholar articles

Rama Osama Abu Alez
University of Tabuk, Tabuk, Saudi Arabia.
PubMed articlesGoogle scholar articles


Correspondence to:
. King Salman Armed Forces Hospital, Tabuk, Saudi Arabia.; aj.wa@hotmail.com

Publication history
Received 26 Aug 2020
Accepted 30 Sep 2020
Published online 14 Oct 2020
Published in print 05 Nov 2020

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Pubmed Style

Ajwah IM, Alqulayti WM, Algrani MS, Altuwayjiri MT, Alatawi SYS, Alqahtani YSM, Albalawi RK, Almutairi HA, Alblowi YH, Almehmadi AS, Albalawi MAS, Albalawi AFA, Alshehri WK, Jarallah MA, Aljohani WS, Alez ROA. Role of serotonin reuptake inhibitor (SSRI) therapies as a therapeutic option for irritable bowel syndrome: a brief review. IJMDC. 2020; 4(11): 1980-1983. doi:10.24911/IJMDC.51-1598469297


Web Style

Ajwah IM, Alqulayti WM, Algrani MS, Altuwayjiri MT, Alatawi SYS, Alqahtani YSM, Albalawi RK, Almutairi HA, Alblowi YH, Almehmadi AS, Albalawi MAS, Albalawi AFA, Alshehri WK, Jarallah MA, Aljohani WS, Alez ROA. Role of serotonin reuptake inhibitor (SSRI) therapies as a therapeutic option for irritable bowel syndrome: a brief review. http://www.ijmdc.com/?mno=129119 [Access: January 27, 2021]. doi:10.24911/IJMDC.51-1598469297


AMA (American Medical Association) Style

Ajwah IM, Alqulayti WM, Algrani MS, Altuwayjiri MT, Alatawi SYS, Alqahtani YSM, Albalawi RK, Almutairi HA, Alblowi YH, Almehmadi AS, Albalawi MAS, Albalawi AFA, Alshehri WK, Jarallah MA, Aljohani WS, Alez ROA. Role of serotonin reuptake inhibitor (SSRI) therapies as a therapeutic option for irritable bowel syndrome: a brief review. IJMDC. 2020; 4(11): 1980-1983. doi:10.24911/IJMDC.51-1598469297


Vancouver/ICMJE Style

Ajwah IM, Alqulayti WM, Algrani MS, Altuwayjiri MT, Alatawi SYS, Alqahtani YSM, Albalawi RK, Almutairi HA, Alblowi YH, Almehmadi AS, Albalawi MAS, Albalawi AFA, Alshehri WK, Jarallah MA, Aljohani WS, Alez ROA. Role of serotonin reuptake inhibitor (SSRI) therapies as a therapeutic option for irritable bowel syndrome: a brief review. IJMDC. (2020), [cited January 27, 2021]; 4(11): 1980-1983. doi:10.24911/IJMDC.51-1598469297


Harvard Style

Ajwah, I. M., Alqulayti, . W. M., Algrani, . M. S., Altuwayjiri, . M. T., Alatawi, . S. Y. S., Alqahtani, . Y. S. M., Albalawi, . R. K., Almutairi, . H. A., Alblowi, . Y. H., Almehmadi, . A. S., Albalawi, . M. A. S., Albalawi, . A. F. A., Alshehri, . W. K., Jarallah, . M. A., Aljohani, . W. S. & Alez, . R. O. A. (2020) Role of serotonin reuptake inhibitor (SSRI) therapies as a therapeutic option for irritable bowel syndrome: a brief review. IJMDC, 4 (11), 1980-1983. doi:10.24911/IJMDC.51-1598469297


Turabian Style

Ajwah, Ibrahim Mahmoud, Waad Maher Alqulayti, Maram Salim Algrani, Maryam Talal Altuwayjiri, Sahar Yahya S Alatawi, Yazeed Saeed M Alqahtani, Razan Kamel Albalawi, Hadeel Ahmed Almutairi, Yassmeen Hmoud Alblowi, Alaa Sulaiman Almehmadi, Muflih Abdullah Saed Albalawi, Abdulmajeed Faisal A Albalawi, Waleed Khaled Alshehri, Maram Ali Jarallah, Wejdan Saleem Aljohani, and Rama Osama Abu Alez. 2020. Role of serotonin reuptake inhibitor (SSRI) therapies as a therapeutic option for irritable bowel syndrome: a brief review. International Journal of Medicine in Developing Countries, 4 (11), 1980-1983. doi:10.24911/IJMDC.51-1598469297


Chicago Style

Ajwah, Ibrahim Mahmoud, Waad Maher Alqulayti, Maram Salim Algrani, Maryam Talal Altuwayjiri, Sahar Yahya S Alatawi, Yazeed Saeed M Alqahtani, Razan Kamel Albalawi, Hadeel Ahmed Almutairi, Yassmeen Hmoud Alblowi, Alaa Sulaiman Almehmadi, Muflih Abdullah Saed Albalawi, Abdulmajeed Faisal A Albalawi, Waleed Khaled Alshehri, Maram Ali Jarallah, Wejdan Saleem Aljohani, and Rama Osama Abu Alez. "Role of serotonin reuptake inhibitor (SSRI) therapies as a therapeutic option for irritable bowel syndrome: a brief review." International Journal of Medicine in Developing Countries 4 (2020), 1980-1983. doi:10.24911/IJMDC.51-1598469297


MLA (The Modern Language Association) Style

Ajwah, Ibrahim Mahmoud, Waad Maher Alqulayti, Maram Salim Algrani, Maryam Talal Altuwayjiri, Sahar Yahya S Alatawi, Yazeed Saeed M Alqahtani, Razan Kamel Albalawi, Hadeel Ahmed Almutairi, Yassmeen Hmoud Alblowi, Alaa Sulaiman Almehmadi, Muflih Abdullah Saed Albalawi, Abdulmajeed Faisal A Albalawi, Waleed Khaled Alshehri, Maram Ali Jarallah, Wejdan Saleem Aljohani, and Rama Osama Abu Alez. "Role of serotonin reuptake inhibitor (SSRI) therapies as a therapeutic option for irritable bowel syndrome: a brief review." International Journal of Medicine in Developing Countries 4.11 (2020), 1980-1983. Print. doi:10.24911/IJMDC.51-1598469297


APA (American Psychological Association) Style

Ajwah, I. M., Alqulayti, . W. M., Algrani, . M. S., Altuwayjiri, . M. T., Alatawi, . S. Y. S., Alqahtani, . Y. S. M., Albalawi, . R. K., Almutairi, . H. A., Alblowi, . Y. H., Almehmadi, . A. S., Albalawi, . M. A. S., Albalawi, . A. F. A., Alshehri, . W. K., Jarallah, . M. A., Aljohani, . W. S. & Alez, . R. O. A. (2020) Role of serotonin reuptake inhibitor (SSRI) therapies as a therapeutic option for irritable bowel syndrome: a brief review. International Journal of Medicine in Developing Countries, 4 (11), 1980-1983. doi:10.24911/IJMDC.51-1598469297


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