Assessment of biomarkers for sepsis and their role in the diagnosis and prognosis of patients with bacterial infections

Manaf M. Alqahtani; Abdulkarim Abdulrahman; Salman Alali; Mohamed Abdulla Bucheeri

doi:10.24911/IJMDC.51-1586013522

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Original Article

Online Publishing Date:
20 / 07 / 2020

IJMDC. 2020; 4(8): 1123-1129

doi: 10.24911/IJMDC.51-1586013522

Assessment of biomarkers for sepsis and their role in the diagnosis and prognosis of patients with bacterial infections

Manaf M. Alqahtani, Abdulkarim Abdulrahman, Salman Alali, Mohamed Abdulla Bucheeri.

Abstract
Background: Sepsis, which is a serious clinical condition and an effect of a system-wide inflammation, may result in multiorgan failure and mortality in patients. Currently, procalcitonin (PCT) and C-reactive protein (CRP) are utilized globally. In a recent emergence, the ability of presepsin to identify sepsis is explored, but its prognosis needs to be established.
Methods: The prospective study consisting of 58 cases with possible bacterial sepsis was studied. The analysis of several inflammatory markers including CRP, white blood cells, lactate, PCT, and presepsin was accomplished. Inpatients were followed up, and their data on mortality, the necessity of renal replacement therapy (RRT), and inotropic support were cumulated. The prospects of the biomarkers were analyzed by the use of logistic regression models. The p-value < 0.05 is considered to be statistically significant.
Results: About 1,000 pg/ml increase in presepsin was useful in predicting mortality by 40% and the need for RRT by 73% (p = 0.027). Diagnostic sensitivity, specificity, and area under the curve of presepsin for mortality and RRT were 0.786, 0.524, and 0.721 (p = 0.014) and 1.0, 0.565, and 0.946 (p < 0.0001), respectively. The role of PCT and lactate was insignificant as predicting and diagnostic markers.
Conclusion: Presepsin can be a prospective biomarker in the identification and progression of sepsis, prediction of mortality, and a decisive parameter about the necessity of RRT.

Key words: Sepsis, presepsin, procalcitonin, c-reactive protein, renal replacement therapy

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Pubmed Style

Alqahtani MM, Abdulrahman A, Alali S, Bucheeri MA. Assessment of biomarkers for sepsis and their role in the diagnosis and prognosis of patients with bacterial infections. IJMDC. 2020; 4(8): 1123-1129. doi:10.24911/IJMDC.51-1586013522

Web Style

Alqahtani MM, Abdulrahman A, Alali S, Bucheeri MA. Assessment of biomarkers for sepsis and their role in the diagnosis and prognosis of patients with bacterial infections. https://www.ijmdc.com/?mno=96978 [Access: March 26, 2024]. doi:10.24911/IJMDC.51-1586013522

AMA (American Medical Association) Style

Alqahtani MM, Abdulrahman A, Alali S, Bucheeri MA. Assessment of biomarkers for sepsis and their role in the diagnosis and prognosis of patients with bacterial infections. IJMDC. 2020; 4(8): 1123-1129. doi:10.24911/IJMDC.51-1586013522

Vancouver/ICMJE Style

Alqahtani MM, Abdulrahman A, Alali S, Bucheeri MA. Assessment of biomarkers for sepsis and their role in the diagnosis and prognosis of patients with bacterial infections. IJMDC. (2020), [cited March 26, 2024]; 4(8): 1123-1129. doi:10.24911/IJMDC.51-1586013522

Harvard Style

Alqahtani, M. M., Abdulrahman, . A., Alali, . S. & Bucheeri, . M. A. (2020) Assessment of biomarkers for sepsis and their role in the diagnosis and prognosis of patients with bacterial infections. IJMDC, 4 (8), 1123-1129. doi:10.24911/IJMDC.51-1586013522

Turabian Style

Alqahtani, Manaf M., Abdulkarim Abdulrahman, Salman Alali, and Mohamed Abdulla Bucheeri. 2020. Assessment of biomarkers for sepsis and their role in the diagnosis and prognosis of patients with bacterial infections. International Journal of Medicine in Developing Countries, 4 (8), 1123-1129. doi:10.24911/IJMDC.51-1586013522

Chicago Style

Alqahtani, Manaf M., Abdulkarim Abdulrahman, Salman Alali, and Mohamed Abdulla Bucheeri. "Assessment of biomarkers for sepsis and their role in the diagnosis and prognosis of patients with bacterial infections." International Journal of Medicine in Developing Countries 4 (2020), 1123-1129. doi:10.24911/IJMDC.51-1586013522

MLA (The Modern Language Association) Style

Alqahtani, Manaf M., Abdulkarim Abdulrahman, Salman Alali, and Mohamed Abdulla Bucheeri. "Assessment of biomarkers for sepsis and their role in the diagnosis and prognosis of patients with bacterial infections." International Journal of Medicine in Developing Countries 4.8 (2020), 1123-1129. Print. doi:10.24911/IJMDC.51-1586013522

APA (American Psychological Association) Style

Alqahtani, M. M., Abdulrahman, . A., Alali, . S. & Bucheeri, . M. A. (2020) Assessment of biomarkers for sepsis and their role in the diagnosis and prognosis of patients with bacterial infections. International Journal of Medicine in Developing Countries, 4 (8), 1123-1129. doi:10.24911/IJMDC.51-1586013522

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