L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study

Osama Safdar; Ghazal Jambi; Omar Asaad; Lujain Hassan; Lujain AlDahlawi; Abdalrashid F. Halawani; Mohammed Jamjoom; Bahaa Shaikhoon; Ahmad Azhar; Zaher F. Zaher; Shatha Albokhari; Mohammed Shalaby

doi:10.24911/IJMDC.51-1574511938

2024, Vol: 8, Issue: 11

8 / 11Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

« Previous Article

Original Article
Online Published: 23 Jan 2020

IJMDC. 2020; 4(3): 612-619

doi: 10.24911/IJMDC.51-1574511938

L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study

Osama Safdar, Ghazal Jambi, Omar Asaad, Lujain Hassan, Lujain Aldahlawi, Abdalrashid F. Halawani, Mohammed Jamjoom, Bahaa Shaikhoon, Ahmad Azhar, Zaher F. Zaher, Shatha Albokhari, Mohammed Shalaby.

Cited By: 1

Abstract
Background: Patients with end-stage renal failure resort to different forms of renal replacement therapy, including peritoneal dialysis, hemodialysis, and renal transplantation. Hemodialysis patients often have reduced L-carnitine levels predisposing them to different musculoskeletal myopathies. This study aims to evaluate the beneficial circumstances of administering L-carnitine to dialyzed patients regarding improvements in the values of Parathyroid hormone (PTH), Calcium (Ca), Hemoglobin (HB), and Vitamin D levels (Vit D).
Methodology: This experimental study was conducted in a non-randomized manner among a sample size of seven pediatric patients under 18 years of age undergoing dialysis with low L-carnitine levels in King Abdul-Aziz University Hospital, throughout 6 to 10 months. L-carnitine was administered at a fixed dose of 50 mg/kg. Our focus was directed on the levels PTH, Ca2+, Hb, VitD, and PO4.
Results: The mean of phosphate was not significant with p-value 0.499. The mean of PTH level before administering the drug was 134.26 and after administering the drug it was found 57.41. This decrease was statistically significant with p-value 0.028. The mean of Ca was not significant with p-value 0.735. The mean of HB is not significant with p-value 0.499. The mean of Vit D was not significant (p-value 0.237).
Conclusion: The only significant statistical result was involving PTH. Decreasing the level of PTH had several advantages most importantly it led to reduction of bone resorption; therefore, maintaining bone density and decreasing the likelihood of developing degenerative bone diseases.

Key words: Pediatric, hemodialysis, L-carnitine

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Osama Safdar Articles by Ghazal Jambi Articles by Omar Asaad Articles by Lujain Hassan Articles by Lujain AlDahlawi Articles by Abdalrashid F. Halawani Articles by Mohammed Jamjoom Articles by Bahaa Shaikhoon Articles by Ahmad Azhar Articles by Zaher F. Zaher Articles by Shatha Albokhari Articles by Mohammed Shalaby
	on Google
	on Google Scholar

This Article Cited By the following articles

The Nutraceutical Value of Carnitine and Its Use in Dietary Supplements Molecules 2020; 25(9): 2127.	1

How to Cite this Article

Pubmed Style

Safdar O, Jambi G, Asaad O, Hassan L, Aldahlawi L, Halawani AF, Jamjoom M, Shaikhoon B, Azhar A, Zaher ZF, Albokhari S, Shalaby M. L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. IJMDC. 2020; 4(3): 612-619. doi:10.24911/IJMDC.51-1574511938

Web Style

Safdar O, Jambi G, Asaad O, Hassan L, Aldahlawi L, Halawani AF, Jamjoom M, Shaikhoon B, Azhar A, Zaher ZF, Albokhari S, Shalaby M. L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. https://www.ijmdc.com/?mno=74994 [Access: January 14, 2025]. doi:10.24911/IJMDC.51-1574511938

AMA (American Medical Association) Style

Safdar O, Jambi G, Asaad O, Hassan L, Aldahlawi L, Halawani AF, Jamjoom M, Shaikhoon B, Azhar A, Zaher ZF, Albokhari S, Shalaby M. L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. IJMDC. 2020; 4(3): 612-619. doi:10.24911/IJMDC.51-1574511938

Vancouver/ICMJE Style

Safdar O, Jambi G, Asaad O, Hassan L, Aldahlawi L, Halawani AF, Jamjoom M, Shaikhoon B, Azhar A, Zaher ZF, Albokhari S, Shalaby M. L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. IJMDC. (2020), [cited January 14, 2025]; 4(3): 612-619. doi:10.24911/IJMDC.51-1574511938

Harvard Style

Safdar, O., Jambi, . G., Asaad, . O., Hassan, . L., Aldahlawi, . L., Halawani, . A. F., Jamjoom, . M., Shaikhoon, . B., Azhar, . A., Zaher, . Z. F., Albokhari, . S. & Shalaby, . M. (2020) L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. IJMDC, 4 (3), 612-619. doi:10.24911/IJMDC.51-1574511938

Turabian Style

Safdar, Osama, Ghazal Jambi, Omar Asaad, Lujain Hassan, Lujain Aldahlawi, Abdalrashid F. Halawani, Mohammed Jamjoom, Bahaa Shaikhoon, Ahmad Azhar, Zaher F. Zaher, Shatha Albokhari, and Mohammed Shalaby. 2020. L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. International Journal of Medicine in Developing Countries, 4 (3), 612-619. doi:10.24911/IJMDC.51-1574511938

Chicago Style

Safdar, Osama, Ghazal Jambi, Omar Asaad, Lujain Hassan, Lujain Aldahlawi, Abdalrashid F. Halawani, Mohammed Jamjoom, Bahaa Shaikhoon, Ahmad Azhar, Zaher F. Zaher, Shatha Albokhari, and Mohammed Shalaby. "L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study." International Journal of Medicine in Developing Countries 4 (2020), 612-619. doi:10.24911/IJMDC.51-1574511938

MLA (The Modern Language Association) Style

Safdar, Osama, Ghazal Jambi, Omar Asaad, Lujain Hassan, Lujain Aldahlawi, Abdalrashid F. Halawani, Mohammed Jamjoom, Bahaa Shaikhoon, Ahmad Azhar, Zaher F. Zaher, Shatha Albokhari, and Mohammed Shalaby. "L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study." International Journal of Medicine in Developing Countries 4.3 (2020), 612-619. Print. doi:10.24911/IJMDC.51-1574511938

APA (American Psychological Association) Style

Safdar, O., Jambi, . G., Asaad, . O., Hassan, . L., Aldahlawi, . L., Halawani, . A. F., Jamjoom, . M., Shaikhoon, . B., Azhar, . A., Zaher, . Z. F., Albokhari, . S. & Shalaby, . M. (2020) L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. International Journal of Medicine in Developing Countries, 4 (3), 612-619. doi:10.24911/IJMDC.51-1574511938

Most Viewed Articles

Most Accessed Articles

Marginal adaptation of fixed prosthodontics
Shahad Mohammed Halawani, Sahar Amer Al-Harbi
IJMDC. 2017; 1(2): 78-84
» Abstract » doi: 10.24911/IJMDC.1.2.7

Parasites in central nervous system
Amal Ahmed Mohamed, Asmaa Mohamed Mansour
IJMDC. 2017; 1(2): 72-77
» Abstract » doi: 10.24911/IJMDC.1.2.6

Non-diabetic retinopathy: a case report
Hassan F. Alkwikbi, Nabil Mamon Abdelfattah, Haithem Mamon Abdelfattah
IJMDC. 2017; 1(1): 33-37
» Abstract » doi: 10.24911/IJMDC.1.1.6

Vitamin D deficiency among high school female students in Riyadh
Sahar Mohsen Aldhafeeri, Fatemah Ibraheem Alrawaji, Abrar Mubarak Algharbi, Alanoud Abdullah Alhessan, Ayat Sami Qabaja, Ghaleah Abdulaziz Alnassar, Ghaliah Ofayn Alsulami, Mashael Belal Alrubaian, Norah Abdulaziz Alhatim, Salehah Salih Alotaibi, Zahra Ali Alkhamees
IJMDC. 2017; 1(1): 18-23
» Abstract » doi: 10.24911/IJMDC.1.1.4

Prognosis of chronic complications of diabetes mellitus (DM) after multiple events of diabetic ketoacidosis (DKA)
Baraa Faiez Rajab, Anwar Essa Alamrim, Ali Essa Alamri
IJMDC. 2019; 3(5): 474-479
» Abstract » doi: 10.24911/IJMDC.51-1546551993

Most Downloaded

Top Downloaded Articles

Anti-IL-17 markedly inhibited the in vitro granuloma induced by Schistosoma mansoni soluble egg antigen.
Asmaa Ezz, Irene S. Gmail, Fatma Elzahraa H. Salem, Rabab Salama, Soad Nady
IJMDC. 2018; 2(January 2018): 38-46
» Abstract » doi: 10.24911/IJMDC.2.1.7

Antibiotic Resistance Crisis
Nuha Saad Mobarki, Buthaina Abdullah Almerabi, Ahmad Hattan Hattan
IJMDC. 2019; 3(6): 561-564
» Abstract » doi: 10.24911/IJMDC.51-1549060699

The knowledge of mothers about children malnutrition and associated factors
Anas Abdulrahman Aljohani, Mujahid Abdulrahman Aljohani
IJMDC. 2020; 4(1): 7-11
» Abstract » doi: 10.24911/IJMDC.51-1541620358

Knowledge and attitude of caregivers of cerebral palsy children in Riyadh city
Abdulaziz Alruwaished, Baleegh Ali, Lubna Abdullah Alhowaimil , Abaraa adullah Alhowaimil, Najd Abdullah Alhowaimil, Aminah Alessa
IJMDC. 2020; 4(1): 12-17
» Abstract » doi: 10.24911/IJMDC.51-1547833051

Most Cited Articles

Most Cited Articles

Antibiotic Resistance Crisis
Nuha Saad Mobarki, Buthaina Abdullah Almerabi, Ahmad Hattan Hattan
IJMDC. 2019; 3(6): 561-564
» Abstract » doi: 10.24911/IJMDC.51-1549060699
Cited : 34 times [Click to see citing articles]

Prevalence of depression, anxiety and stress among diabetes mellitus patients in Arar, Northern Saudi Arabia
AMohammed Elamin Mukrim, Nujud Muteb D. Alshammari, Wurud Muteb D. Alshammari, Maali Subhi T. Alshammari, Yousef Nasif R. Alshammari, Abdulaziz Sael M. Alshammari, Maisa Hamad F. Alanazi, Abdulelah Abdulrhman F. Alzammam, Muharib Mana M. Alshammari, Slwa Khaled Abu Asyah, Aseel Jamal Alzuhayri, Mushref Saeid Alshammari
IJMDC. 2019; 3(3): 229-233
» Abstract » doi: 10.24911/IJMDC.51-1542576396
Cited : 8 times [Click to see citing articles]

Knowledge, attitude, and practice of breast self-examination toward breast cancer among female students at King Saud University in Riyadh, Saudi Arabia
Abdullah Nasser Alomair, Dania Ghazi Felemban, Mohannad Sami Felemban, Jameel Abdullah Awadain, Ammar Saud Altowairqi, Nawaf Fawzan Alfawzan, Fatimah Mohammed Almazayen, Abdulrahman Jalwi Korkoman, Nawaf Saad Alrusayyis
IJMDC. 2020; 4(2): 429-434
» Abstract » doi: 10.24911/IJMDC.51-1576668182
Cited : 8 times [Click to see citing articles]

Population awareness about rheumatoid arthritis in Jazan region, Saudi Arabia
Ahmad Ali Hazzazi, Mohssen Hassen Ageeli, Ahmed Ali Muyidi, Abdulaziz Mohammad Abulgasim, Abdullah Ahmad Yateemi, Nabil Alhakami
IJMDC. 2020; 4(3): 668-675
» Abstract » doi: 10.24911/IJMDC.51-1576010943
Cited : 4 times [Click to see citing articles]

Prevalence and factors associated with depression among health care workers in National Guard Hospital in Riyadh, KSA
Noor Mohammad AlFahhad
IJMDC. 2018; 2(September 2018): 92-96
» Abstract » doi: 10.24911/IJMDC.51-1526306040
Cited : 4 times [Click to see citing articles]

About International Journal of Medicine in Developing Countries

Contact Information

How to cite this article