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Review Article
Online Published: 25 Dec 2019
 


The effect of Sitagliptin on carotid artery atherosclerosis in type2 diabetes mellitus: a systematic review

Maryam Hussain Al-ayesh, Abdullah Jafar Albariqi, Fatimah Salman Alramadhan, Abdullah Ibrahim Mohammed Alfawzan, Manal Mustafa Alghazal, Majed Abdulaziz Almajdui.


Abstract
Besides the diet and lifestyle modifications usually administered during T2D therapy, oral hypoglycemic drugs is also found to play an important role. Metformin is usually preferred as an initial pharmacological agent for T2D and if metformin monotherapy fails to achieve or maintain the hemoglobin A1c within a period of 3-6 months, usually a second drug is added to control glycemia. Among the add-on therapy options available, Sitagliptin, dipeptidyl peptidase-4 inhibitors are one of the recent and widely used drugs. The current review was aimed at exploring the effect of Sitagliptin on carotid artery atherosclerosis in type 2 diabetic patients. Multiple databases were employed in the literature review, which focused on studies that either reported the association or non-association of a Sitagliptin with carotid artery atherosclerosis. Using appropriate search terms, 8 articles published between analyzed and selected 18 articles published between the years of 2012-2018. The current systematic review concludes that Sitagliptin could be considered as a promising therapy for atherosclerosis in type 2 diabetes mellitus patients.

Key words: Sitagliptin, T2DM, atherosclerosis, carotid artery thickness


 
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How to Cite this Article
Pubmed Style

Al-ayesh MH, Albariqi AJ, Alramadhan FS, Alfawzan AIM, Alghazal MM, Almajdui MA. The effect of Sitagliptin on carotid artery atherosclerosis in type2 diabetes mellitus: a systematic review. IJMDC. 2020; 4(1): 240-243. doi:10.24911/IJMDC.51-1572542356

Web Style

Al-ayesh MH, Albariqi AJ, Alramadhan FS, Alfawzan AIM, Alghazal MM, Almajdui MA. The effect of Sitagliptin on carotid artery atherosclerosis in type2 diabetes mellitus: a systematic review. https://www.ijmdc.com/?mno=71925 [Access: July 04, 2025]. doi:10.24911/IJMDC.51-1572542356

AMA (American Medical Association) Style

Al-ayesh MH, Albariqi AJ, Alramadhan FS, Alfawzan AIM, Alghazal MM, Almajdui MA. The effect of Sitagliptin on carotid artery atherosclerosis in type2 diabetes mellitus: a systematic review. IJMDC. 2020; 4(1): 240-243. doi:10.24911/IJMDC.51-1572542356


Vancouver/ICMJE Style

Al-ayesh MH, Albariqi AJ, Alramadhan FS, Alfawzan AIM, Alghazal MM, Almajdui MA. The effect of Sitagliptin on carotid artery atherosclerosis in type2 diabetes mellitus: a systematic review. IJMDC. (2020), [cited July 04, 2025]; 4(1): 240-243. doi:10.24911/IJMDC.51-1572542356


Harvard Style

Al-ayesh, M. H., Albariqi, . A. J., Alramadhan, . F. S., Alfawzan, . A. I. M., Alghazal, . M. M. & Almajdui, . M. A. (2020) The effect of Sitagliptin on carotid artery atherosclerosis in type2 diabetes mellitus: a systematic review. IJMDC, 4 (1), 240-243. doi:10.24911/IJMDC.51-1572542356


Turabian Style

Al-ayesh, Maryam Hussain, Abdullah Jafar Albariqi, Fatimah Salman Alramadhan, Abdullah Ibrahim Mohammed Alfawzan, Manal Mustafa Alghazal, and Majed Abdulaziz Almajdui. 2020. The effect of Sitagliptin on carotid artery atherosclerosis in type2 diabetes mellitus: a systematic review. International Journal of Medicine in Developing Countries, 4 (1), 240-243. doi:10.24911/IJMDC.51-1572542356


Chicago Style

Al-ayesh, Maryam Hussain, Abdullah Jafar Albariqi, Fatimah Salman Alramadhan, Abdullah Ibrahim Mohammed Alfawzan, Manal Mustafa Alghazal, and Majed Abdulaziz Almajdui. "The effect of Sitagliptin on carotid artery atherosclerosis in type2 diabetes mellitus: a systematic review." International Journal of Medicine in Developing Countries 4 (2020), 240-243. doi:10.24911/IJMDC.51-1572542356


MLA (The Modern Language Association) Style

Al-ayesh, Maryam Hussain, Abdullah Jafar Albariqi, Fatimah Salman Alramadhan, Abdullah Ibrahim Mohammed Alfawzan, Manal Mustafa Alghazal, and Majed Abdulaziz Almajdui. "The effect of Sitagliptin on carotid artery atherosclerosis in type2 diabetes mellitus: a systematic review." International Journal of Medicine in Developing Countries 4.1 (2020), 240-243. Print. doi:10.24911/IJMDC.51-1572542356


APA (American Psychological Association) Style

Al-ayesh, M. H., Albariqi, . A. J., Alramadhan, . F. S., Alfawzan, . A. I. M., Alghazal, . M. M. & Almajdui, . M. A. (2020) The effect of Sitagliptin on carotid artery atherosclerosis in type2 diabetes mellitus: a systematic review. International Journal of Medicine in Developing Countries, 4 (1), 240-243. doi:10.24911/IJMDC.51-1572542356




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