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Case Report

IJMDC. 2022; 6(2): 411-414

Approach to alloimmune thrombocytopenia: case report

Authors: Njood A. Alabdulqader, Raghdah A. AlAmri, Razan Z. AlShammari, Abdulrahman A. Alarfaj, Nourah H. Alqahtani.

ABSTRACT

Background: Fetomaternal alloimmune thrombocytopenia (FMAIT) is a rare disease that occurs when the mothers immune system produces antibodies against foreign platelet antigens, which are inherited from the father, in the foetus. These antibodies can cross the placental barrier and opsonized fetal platelets, causing fetal thrombocytopenia and increasing the risk of bleeding. Case Presentation: In this study, the case of a 32-year-old female was presented with an affected first pregnancybwith FMAIT followed by surviving and healthy subsequent pregnancies. After the diagnosis of alloimmune thrombocytopenia was established in the first pregnancy, the management plan for the subsequent pregnancies was maternal administration of IVIG 1 g/kg/week, with the addition of hydrocortisone 0.5 mg/kg/ week from 20 weeks age of gestation until the fetal delivery. Conclusion: FMAIT is one of the most common causes of antenatal fetal bleeding. Timely management is the best way to preserve pregnancy. Effective prophylaxis in antenatal care with IVIG infusion and corticosteroids has been reported. However, no mainstay mode of delivery has been agreed upon until now.

Keywords:
Autoimmune disease, Neonatal alloimmune thrombocytopenia, Fetal Intracranial haemorrhage, Anti-human platelet antigen, IVIG

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Approach to alloimmune thrombocytopenia: case report

Authors
Njood A Alabdulqader
College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia
PubMed articles Google scholar articles

Raghdah A AlAmri
College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia
PubMed articles Google scholar articles

Razan Z AlShammari
College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia
PubMed articles Google scholar articles

Abdulrahman A Alarfaj
College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia
PubMed articles Google scholar articles

Nourah H Alqahtani
Department of Obstetrics and Gynecology, King Fahd Hospital of the University, Dammam, Saudi Arabia.
PubMed articles Google scholar articles

Correspondence to:
. Njood Alabdulqader, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia.; njoodella@outlook.sa

Publication history
Received 11 Dec 2021
Accepted 25 Dec 2021
Published online 30 Dec 2021
Published in print 19 Jan 2022

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Pubmed Style

Alabdulqader NA, AlAmri RA, AlShammari RZ, Alarfaj AA, Alqahtani NH. Approach to alloimmune thrombocytopenia: case report. IJMDC. 2022; 6(2): 411-414. doi:10.24911/IJMDC.51-1639250090

Web Style

Alabdulqader NA, AlAmri RA, AlShammari RZ, Alarfaj AA, Alqahtani NH. Approach to alloimmune thrombocytopenia: case report. https://www.ijmdc.com/?mno=48433 [Access: May 25, 2022]. doi:10.24911/IJMDC.51-1639250090

AMA (American Medical Association) Style

Alabdulqader NA, AlAmri RA, AlShammari RZ, Alarfaj AA, Alqahtani NH. Approach to alloimmune thrombocytopenia: case report. IJMDC. 2022; 6(2): 411-414. doi:10.24911/IJMDC.51-1639250090

Vancouver/ICMJE Style

Alabdulqader NA, AlAmri RA, AlShammari RZ, Alarfaj AA, Alqahtani NH. Approach to alloimmune thrombocytopenia: case report. IJMDC. (2022), [cited May 25, 2022]; 6(2): 411-414. doi:10.24911/IJMDC.51-1639250090

Harvard Style

Alabdulqader, N. A., AlAmri, . R. A., AlShammari, . R. Z., Alarfaj, . A. A. & Alqahtani, . N. H. (2022) Approach to alloimmune thrombocytopenia: case report. IJMDC, 6 (2), 411-414. doi:10.24911/IJMDC.51-1639250090

Turabian Style

Alabdulqader, Njood A., Raghdah A. AlAmri, Razan Z. AlShammari, Abdulrahman A. Alarfaj, and Nourah H. Alqahtani. 2022. Approach to alloimmune thrombocytopenia: case report. International Journal of Medicine in Developing Countries, 6 (2), 411-414. doi:10.24911/IJMDC.51-1639250090

Chicago Style

Alabdulqader, Njood A., Raghdah A. AlAmri, Razan Z. AlShammari, Abdulrahman A. Alarfaj, and Nourah H. Alqahtani. "Approach to alloimmune thrombocytopenia: case report." International Journal of Medicine in Developing Countries 6 (2022), 411-414. doi:10.24911/IJMDC.51-1639250090

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Alabdulqader, N. A., AlAmri, . R. A., AlShammari, . R. Z., Alarfaj, . A. A. & Alqahtani, . N. H. (2022) Approach to alloimmune thrombocytopenia: case report. International Journal of Medicine in Developing Countries, 6 (2), 411-414. doi:10.24911/IJMDC.51-1639250090

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International Journal of Medicine in Developing Countries