Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study

Ali Hussain Alsafar; Hassan Essa Albohamood; Ibrahim Abdullah Alluwaym; Mujtaba Jameel Alzakari; Radi Abdulqader Alobaidi; Mohammad Ali Alawadh; Royes Joseph; Cyril Cyrus

doi:10.24911/IJMDC.51-1609676604

2026, Vol: 10, Issue: 6

10 / 6Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

« Previous Article

Original Article
Online Published: 19 Jan 2021

IJMDC. 2021; 5(2): 688-694

doi: 10.24911/IJMDC.51-1609676604

Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study

Ali Hussain Alsafar, Hassan Essa Albohamood, Ibrahim Abdullah Alluwaym, Mujtaba Jameel Alzakari, Radi Abdulqader Alobaidi, Mohammad Ali Alawadh, Royes Joseph, Cyril Cyrus.

Abstract
Background: Diabetes mellitus (DM) is the most common chronic endocrine disorder worldwide. Statin therapy remains the cornerstone of the primary prevention option for the management of hypercholesterolemia in patients at risk for atherosclerotic cardiovascular disorder. Despite the pivotal role of statin in the management of hypercholesterolemia, several randomized controlled trials, and observational studies have reported that statins worsen glycemia and increase the risk of New-Onset Diabetes Mellitus (NODM). The objective of this study was to validate the potential risk factors of statin-induced NODM in dyslipidemia patients.
Method: Electronic patient records from the King Fahad Hospital of the University, Imam Abdulrahman Bin Faisal University were screened for patients who have been administered statin for more than 1 year. We retrospectively analyzed the factors affecting the development of DM after statin therapy.
Results: Of the 3,562 statin users 150 had incident diabetes with an incidence rate of 4.2% with a relative risk ratio of 1.91 (95% CI: 1.62-2.26). The overall mean age of the study population was 57.72 ± 14.73, and NODM association with older age was seen. Interestingly, 20 mg dose [odds ratio (OR): 7.3; 95% confidence interval (CI): 4.6-11.7] and early users between 1 and 2 years (OR: 37.2; 95% CI: 21.3-65.0) showed a statistically significant effect on NODM.
Conclusion: This hospital-based survey highlights the clinical necessity of performing diabetes screening before initiation of statin therapy. As the risk of NODM increased in the early stages of statin treatment, clinicians should emphasize the need for lifestyle modification and enlighten the new users of statin about the potential benefits and side effects of statin therapy.

Key words: Statins; Diabetes mellitus; Drug-induced diabetes; Atorvastatin; New-onset diabetes mellitus; Treatment risk paradox.

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Ali Hussain Alsafar Articles by Hassan Essa Albohamood Articles by Ibrahim Abdullah Alluwaym Articles by Mujtaba Jameel Alzakari Articles by Radi Abdulqader Alobaidi Articles by Mohammad Ali Alawadh Articles by Royes Joseph Articles by Cyril Cyrus
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Alsafar AH, Albohamood HE, Alluwaym IA, Alzakari MJ, Alobaidi RA, Alawadh MA, Joseph R, Cyrus C. Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study. IJMDC. 2021; 5(2): 688-694. doi:10.24911/IJMDC.51-1609676604

Web Style

Alsafar AH, Albohamood HE, Alluwaym IA, Alzakari MJ, Alobaidi RA, Alawadh MA, Joseph R, Cyrus C. Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study. https://www.ijmdc.com/?mno=39263 [Access: June 27, 2026]. doi:10.24911/IJMDC.51-1609676604

AMA (American Medical Association) Style

Alsafar AH, Albohamood HE, Alluwaym IA, Alzakari MJ, Alobaidi RA, Alawadh MA, Joseph R, Cyrus C. Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study. IJMDC. 2021; 5(2): 688-694. doi:10.24911/IJMDC.51-1609676604

Vancouver/ICMJE Style

Alsafar AH, Albohamood HE, Alluwaym IA, Alzakari MJ, Alobaidi RA, Alawadh MA, Joseph R, Cyrus C. Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study. IJMDC. (2021), [cited June 27, 2026]; 5(2): 688-694. doi:10.24911/IJMDC.51-1609676604

Harvard Style

Alsafar, A. H., Albohamood, . H. E., Alluwaym, . I. A., Alzakari, . M. J., Alobaidi, . R. A., Alawadh, . M. A., Joseph, . R. & Cyrus, . C. (2021) Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study. IJMDC, 5 (2), 688-694. doi:10.24911/IJMDC.51-1609676604

Turabian Style

Alsafar, Ali Hussain, Hassan Essa Albohamood, Ibrahim Abdullah Alluwaym, Mujtaba Jameel Alzakari, Radi Abdulqader Alobaidi, Mohammad Ali Alawadh, Royes Joseph, and Cyril Cyrus. 2021. Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study. International Journal of Medicine in Developing Countries, 5 (2), 688-694. doi:10.24911/IJMDC.51-1609676604

Chicago Style

Alsafar, Ali Hussain, Hassan Essa Albohamood, Ibrahim Abdullah Alluwaym, Mujtaba Jameel Alzakari, Radi Abdulqader Alobaidi, Mohammad Ali Alawadh, Royes Joseph, and Cyril Cyrus. "Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study." International Journal of Medicine in Developing Countries 5 (2021), 688-694. doi:10.24911/IJMDC.51-1609676604

MLA (The Modern Language Association) Style

Alsafar, Ali Hussain, Hassan Essa Albohamood, Ibrahim Abdullah Alluwaym, Mujtaba Jameel Alzakari, Radi Abdulqader Alobaidi, Mohammad Ali Alawadh, Royes Joseph, and Cyril Cyrus. "Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study." International Journal of Medicine in Developing Countries 5.2 (2021), 688-694. Print. doi:10.24911/IJMDC.51-1609676604

APA (American Psychological Association) Style

Alsafar, A. H., Albohamood, . H. E., Alluwaym, . I. A., Alzakari, . M. J., Alobaidi, . R. A., Alawadh, . M. A., Joseph, . R. & Cyrus, . C. (2021) Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study. International Journal of Medicine in Developing Countries, 5 (2), 688-694. doi:10.24911/IJMDC.51-1609676604

Most Viewed Articles

Most Accessed Articles

Marginal adaptation of fixed prosthodontics
Shahad Mohammed Halawani, Sahar Amer Al-Harbi
IJMDC. 2017; 1(2): 78-84
» Abstract » doi: 10.24911/IJMDC.1.2.7

Parasites in central nervous system
Amal Ahmed Mohamed, Asmaa Mohamed Mansour
IJMDC. 2017; 1(2): 72-77
» Abstract » doi: 10.24911/IJMDC.1.2.6

Non-diabetic retinopathy: a case report
Hassan F. Alkwikbi, Nabil Mamon Abdelfattah, Haithem Mamon Abdelfattah
IJMDC. 2017; 1(1): 33-37
» Abstract » doi: 10.24911/IJMDC.1.1.6

Vitamin D deficiency among high school female students in Riyadh
Sahar Mohsen Aldhafeeri, Fatemah Ibraheem Alrawaji, Abrar Mubarak Algharbi, Alanoud Abdullah Alhessan, Ayat Sami Qabaja, Ghaleah Abdulaziz Alnassar, Ghaliah Ofayn Alsulami, Mashael Belal Alrubaian, Norah Abdulaziz Alhatim, Salehah Salih Alotaibi, Zahra Ali Alkhamees
IJMDC. 2017; 1(1): 18-23
» Abstract » doi: 10.24911/IJMDC.1.1.4

Prognosis of chronic complications of diabetes mellitus (DM) after multiple events of diabetic ketoacidosis (DKA)
Baraa Faiez Rajab, Anwar Essa Alamrim, Ali Essa Alamri
IJMDC. 2019; 3(5): 474-479
» Abstract » doi: 10.24911/IJMDC.51-1546551993

Most Downloaded

Top Downloaded Articles

Perception and attitude of medical students towards trauma and orthopedic teaching: a cross-sectional study
Nawaf Hameed Almohammadi, Faisal Ali Almesned, Atif Omar Alhawsah, Sami Aoudah Alahmari, Madloul Jassim Alshammari, Hamad Ali Alkhunayfir
IJMDC. 2019; 3(6): 503-508
» Abstract » doi: 10.24911/IJMDC.51-1548706801

Anti-IL-17 markedly inhibited the in vitro granuloma induced by Schistosoma mansoni soluble egg antigen.
Asmaa Ezz, Irene S. Gmail, Fatma Elzahraa H. Salem, Rabab Salama, Soad Nady
IJMDC. 2018; 2(January 2018): 38-46
» Abstract » doi: 10.24911/IJMDC.2.1.7

Antibiotic Resistance Crisis
Nuha Saad Mobarki, Buthaina Abdullah Almerabi, Ahmad Hattan Hattan
IJMDC. 2019; 3(6): 561-564
» Abstract » doi: 10.24911/IJMDC.51-1549060699

Marginal adaptation of fixed prosthodontics
Shahad Mohammed Halawani, Sahar Amer Al-Harbi
IJMDC. 2017; 1(2): 78-84
» Abstract » doi: 10.24911/IJMDC.1.2.7

Most Cited Articles

Most Cited Articles

Antibiotic Resistance Crisis
Nuha Saad Mobarki, Buthaina Abdullah Almerabi, Ahmad Hattan Hattan
IJMDC. 2019; 3(6): 561-564
» Abstract » doi: 10.24911/IJMDC.51-1549060699
Cited : 34 times [Click to see citing articles]

Prevalence of depression, anxiety and stress among diabetes mellitus patients in Arar, Northern Saudi Arabia
AMohammed Elamin Mukrim, Nujud Muteb D. Alshammari, Wurud Muteb D. Alshammari, Maali Subhi T. Alshammari, Yousef Nasif R. Alshammari, Abdulaziz Sael M. Alshammari, Maisa Hamad F. Alanazi, Abdulelah Abdulrhman F. Alzammam, Muharib Mana M. Alshammari, Slwa Khaled Abu Asyah, Aseel Jamal Alzuhayri, Mushref Saeid Alshammari
IJMDC. 2019; 3(3): 229-233
» Abstract » doi: 10.24911/IJMDC.51-1542576396
Cited : 8 times [Click to see citing articles]

Knowledge, attitude, and practice of breast self-examination toward breast cancer among female students at King Saud University in Riyadh, Saudi Arabia
Abdullah Nasser Alomair, Dania Ghazi Felemban, Mohannad Sami Felemban, Jameel Abdullah Awadain, Ammar Saud Altowairqi, Nawaf Fawzan Alfawzan, Fatimah Mohammed Almazayen, Abdulrahman Jalwi Korkoman, Nawaf Saad Alrusayyis
IJMDC. 2020; 4(2): 429-434
» Abstract » doi: 10.24911/IJMDC.51-1576668182
Cited : 8 times [Click to see citing articles]

Population awareness about rheumatoid arthritis in Jazan region, Saudi Arabia
Ahmad Ali Hazzazi, Mohssen Hassen Ageeli, Ahmed Ali Muyidi, Abdulaziz Mohammad Abulgasim, Abdullah Ahmad Yateemi, Nabil Alhakami
IJMDC. 2020; 4(3): 668-675
» Abstract » doi: 10.24911/IJMDC.51-1576010943
Cited : 4 times [Click to see citing articles]

Prevalence and factors associated with depression among health care workers in National Guard Hospital in Riyadh, KSA
Noor Mohammad AlFahhad
IJMDC. 2018; 2(September 2018): 92-96
» Abstract » doi: 10.24911/IJMDC.51-1526306040
Cited : 4 times [Click to see citing articles]

Effect of inter-pregnancy interval on pregnancy outcome: a prospective study at Fayoum, Egypt
Eman M. Mahfouz, Naglaa A. El-Sherbiny, Wafaa Y. Abdel Wahed, Nashwa S. Hamed
IJMDC. 2018; 2(May 2018): 38-44
» Abstract » doi: 10.24911/IJMDC.51-1520268317
Cited : 4 times [Click to see citing articles]

Diabetic neuropathy in Saudi Arabia: a comprehensive review for further actions
Mohammad Mater Aljohani, Amjad Taj Karam, Ayman Abdulaziz Alamri, Mohammed Hamed Manfaloti, Hussain Abbas Alnakhli, Hatem Ahmed Shaqroon
IJMDC. 2020; 4(11): 2008-2013
» Abstract » doi: 10.24911/IJMDC.51-1601343665
Cited : 4 times [Click to see citing articles]

Public Awareness of coronary artery disease risk factors in Qassim, Saudi Arabia: a cross-sectional study
Abdullah Muzil Albadrani, Saleh Sulaiman Al-Ajlan, Abdullah Saer E. Alharbi, Abdulelah Saud Alharbi, Saif Mohammed Radhi Alharbi
IJMDC. 2020; 4(3): 593-599
» Abstract » doi: 10.24911/IJMDC.51-1572217065
Cited : 4 times [Click to see citing articles]

Ischemic stroke: prevalence of modifiable risk factors in the Saudi population
Muhannad Noor Alharbi, Atheer Khalid Alharbi, Mousa Atqan Alamri, Abdulmalik Ayedh Saad Alharthi, Abdulrahman Moneer Alqerafi, Mohamed Noor Alharbi
IJMDC. 2019; 3(7): 601-603
» Abstract » doi: 10.24911/IJMDC.51-1548376707
Cited : 3 times [Click to see citing articles]

Prevalence and risk factors for diabetic nephropathy in type 2 diabetic patients, Taif City, Saudi Arabia
Basel Saad Alzahrani, Turki Hamdan Alzidani, Abdullah Mohammed Alturkistani, Hani Abozaid
IJMDC. 2019; 3(2): 167-172
» Abstract » doi: 10.24911/IJMDC.51-1541336905
Cited : 3 times [Click to see citing articles]

Assessment of knowledge and awareness regarding thyroid disorders among Saudi people
Assem Saleh Ali Almuzaini , Bayan ahmad I Alshareef , Sundos Hamoud O Alghamdi, Ayman Adnan Munshy, Abdulmajeed Khalid M. Aljarallah, Saud Abdulaziz A Salman, Khalid Saud Alroqi, Reem Dayel A Alkhaldi
IJMDC. 2019; 3(12): 1070-1076
» Abstract » doi: 10.24911/IJMDC.51-1568037206
Cited : 3 times [Click to see citing articles]

Assessment of knowledge, attitude, and practice in relation to use of isotretinoin among Al-Madinah population, Saudi Arabia
Amr Molla, Hassan Abdullah Alrizqi, Emtinan Mohammed Salem Alruhaili, Saad Abdullah Alrizqi, Arwa Musaad Alsubhi
IJMDC. 2020; 4(1): 107-112
» Abstract » doi: 10.24911/IJMDC.51-1571752077
Cited : 3 times [Click to see citing articles]

Ethical considerations in doctors & pharmaceutical industries relationship: a narrative review
Mohammed Saud Almasri, Yousef Rafat Bukhari, Bandar Saleh Alzuair, Mansour Khalid Almadi, Amro Khalid Bin Abdulrahman
IJMDC. 2020; 4(1): 244-252
» Abstract » doi: 10.24911/IJMDC.51-1572794591
Cited : 3 times [Click to see citing articles]

Assessment of the knowledge of pregnant women regarding the effects of GDM on mothers and neonates at a Maternal and Children hospital in Najran, Saudi Arabia
Amina Abdo Salhi, Medical Intern, Majed Saeed Alshahrani, Maram Mohammed Alyamin, Waad Ahmed Hamdi, Sarah Raja Alyami, Albatool Saleh Almagbool, Nujoud Hamad Almoqati, Seham Hamad Almoqati, Esra'a Amer Nasser Al-Saaed, Hessa Salem Al Habes, Batool Mubarak Abdullah Alwdei, Ahlam Yhya Saeed Alyami, Wesal Ahmed Alassiri
IJMDC. 2019; 3(4): 370-375
» Abstract » doi: 10.24911/IJMDC.51-1545817090
Cited : 3 times [Click to see citing articles]

Awareness of the Saudi population about the role of the Emergency Rooms
Zead Ibrahim A. Alhussain, Mohammed Ali A. Alghamdi, Rana Mohamed Ahmed, Abdullah Yahya Aldhban, Abdulrahman Ali Alghamdi, Naif Shalan J. Alalyani
IJMDC. 2019; 3(11): 957-962
» Abstract » doi: 10.24911/IJMDC.51-1568717752
Cited : 3 times [Click to see citing articles]

About International Journal of Medicine in Developing Countries

Contact Information

How to cite this article