Original Article
IJMDC. 2022; 6(2): 293-300
A cross-sectional study to find the prevalence of amiodarone related adverse effects in patients with various cardiovascular disorders in a teaching hospital in Western Area of Saudi Arabia
Authors: Ahmad Shaker Ali, Ashraf AlBukhari, Mazen Humayran, Abdulaziz AlShamrani, Maan Samkari, Abdulrahman Batarfi, Abdullah Duwaidi.
ABSTRACT
Background: Amiodarone (AMI) has been increasingly used to treat acute arrhythmic episodes in patients with cardiovascular disorders. However, adverse effects of this drug caused by poor clinical follow-up and careless administration have been reported; hence, further attention to and research on this topic is warranted. This study aimed to identify AMI use and adverse effects among patients at King Abdulaziz University Hospital (KAUH) and explore any correlations between adverse effects and risk factors. Methods: This study retrospectively analyzed data from the electronic health records of 142 patients with arrhythmia receiving AMI treatment at KAUH from January 2016 to December 2018, regardless of indication, age, duration, and dose. We excluded patients with: (1) insufficient data regarding the AMI dose and duration, (2) no clinical follow-up, and (3) lack of baseline clinical parameters. Results: We found that 20.4% of patients experienced adverse effects after AMI treatment. Patients with underlying comorbidities, such as hypertension, diabetes, and thyroid dysfunction, were more likely to experience AMI adverse effects. Further, adverse effects were observed more frequently in women, older adults, patients with low body mass index, and patients administered high doses of AMI. Conclusion: Our findings suggest that AMI treatment should accompany meticulous clinical follow-up. This may direct the clinician to either decrease dosage, discontinue AMI treatment, or seek alternative drugs once adverse effects appear.
Keywords:
Amiodarone, arrhythmia, comorbidity, adverse effects, cardiovascular disorder
Authors
Ahmad Shaker Ali
Department of Pharmacology, King Abdulaziz University, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles
Ashraf AlBukhari
Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles
Mazen Humayran
Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles
Abdulaziz AlShamrani
Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles
Maan Samkari
Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles
Abdulrahman Batarfi
Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles
Abdullah Duwaidi
Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles
Correspondence to:
. Ashraf AlBukhari, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.; ashraf.albukhari97@gmail.com
Publication history
Received 03 Dec 2021
Accepted 25 Dec 2021
Published online 25 Dec 2021
Published in print 19 Jan 2022
How to cite this article?
Export to EndNote Export to refManPubmed Style
Ali AS, AlBukhari A, Humayran M, AlShamrani A, Samkari M, Batarfi A, Duwaidi A. A cross-sectional study to find the prevalence of amiodarone related adverse effects in patients with various cardiovascular disorders in a teaching hospital in Western Area of Saudi Arabia. IJMDC. 2022; 6(2): 293-300. doi:10.24911/IJMDC.51-1638557102
Web Style
Ali AS, AlBukhari A, Humayran M, AlShamrani A, Samkari M, Batarfi A, Duwaidi A. A cross-sectional study to find the prevalence of amiodarone related adverse effects in patients with various cardiovascular disorders in a teaching hospital in Western Area of Saudi Arabia. https://www.ijmdc.com/?mno=38513 [Access: May 25, 2022]. doi:10.24911/IJMDC.51-1638557102
AMA (American Medical Association) Style
Ali AS, AlBukhari A, Humayran M, AlShamrani A, Samkari M, Batarfi A, Duwaidi A. A cross-sectional study to find the prevalence of amiodarone related adverse effects in patients with various cardiovascular disorders in a teaching hospital in Western Area of Saudi Arabia. IJMDC. 2022; 6(2): 293-300. doi:10.24911/IJMDC.51-1638557102
Vancouver/ICMJE Style
Ali AS, AlBukhari A, Humayran M, AlShamrani A, Samkari M, Batarfi A, Duwaidi A. A cross-sectional study to find the prevalence of amiodarone related adverse effects in patients with various cardiovascular disorders in a teaching hospital in Western Area of Saudi Arabia. IJMDC. (2022), [cited May 25, 2022]; 6(2): 293-300. doi:10.24911/IJMDC.51-1638557102
Harvard Style
Ali, A. S., AlBukhari, . A., Humayran, . M., AlShamrani, . A., Samkari, . M., Batarfi, . A. & Duwaidi, . A. (2022) A cross-sectional study to find the prevalence of amiodarone related adverse effects in patients with various cardiovascular disorders in a teaching hospital in Western Area of Saudi Arabia. IJMDC, 6 (2), 293-300. doi:10.24911/IJMDC.51-1638557102
Turabian Style
Ali, Ahmad Shaker, Ashraf AlBukhari, Mazen Humayran, Abdulaziz AlShamrani, Maan Samkari, Abdulrahman Batarfi, and Abdullah Duwaidi. 2022. A cross-sectional study to find the prevalence of amiodarone related adverse effects in patients with various cardiovascular disorders in a teaching hospital in Western Area of Saudi Arabia. International Journal of Medicine in Developing Countries, 6 (2), 293-300. doi:10.24911/IJMDC.51-1638557102
Chicago Style
Ali, Ahmad Shaker, Ashraf AlBukhari, Mazen Humayran, Abdulaziz AlShamrani, Maan Samkari, Abdulrahman Batarfi, and Abdullah Duwaidi. "A cross-sectional study to find the prevalence of amiodarone related adverse effects in patients with various cardiovascular disorders in a teaching hospital in Western Area of Saudi Arabia." International Journal of Medicine in Developing Countries 6 (2022), 293-300. doi:10.24911/IJMDC.51-1638557102
MLA (The Modern Language Association) Style
Ali, Ahmad Shaker, Ashraf AlBukhari, Mazen Humayran, Abdulaziz AlShamrani, Maan Samkari, Abdulrahman Batarfi, and Abdullah Duwaidi. "A cross-sectional study to find the prevalence of amiodarone related adverse effects in patients with various cardiovascular disorders in a teaching hospital in Western Area of Saudi Arabia." International Journal of Medicine in Developing Countries 6.2 (2022), 293-300. Print. doi:10.24911/IJMDC.51-1638557102
APA (American Psychological Association) Style
Ali, A. S., AlBukhari, . A., Humayran, . M., AlShamrani, . A., Samkari, . M., Batarfi, . A. & Duwaidi, . A. (2022) A cross-sectional study to find the prevalence of amiodarone related adverse effects in patients with various cardiovascular disorders in a teaching hospital in Western Area of Saudi Arabia. International Journal of Medicine in Developing Countries, 6 (2), 293-300. doi:10.24911/IJMDC.51-1638557102
Article Statistics
Request permissions
If you wish to reuse any part or all of this article please contact the copyright holder, contact@ijmdc.com.
Copyright ©2022 Discover STM Publishing. All Rights Reserved.