IJMDC. 2022; 6(6): 875-881

Mesenchymal stem cell-based therapies as a recent treatment modality in COVID-19: possibilities and challenges

Authors: Gamal Kenawy, Yasmeen Alfouzan, Maryam Bajaber, Hadeel Alqasem, Shaimaa Banaji, Nurah Alkhteeb.

ABSTRACT

Coronavirus disease (COVID-19), is a recently discovered respiratory disease due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has unexpectedly become a widespread pandemic. Yet, because of the absence of evidence, no effective COVID-19 treatment exists. Preventing infection, detecting instances, and providing supportive care are the main focuses of management. The medical community is curious about the promising recent use of Mesenchymal stem cells (MSCs)-based therapies in a small number of seriously unwell patients. Consequently, numerous clinical trials were registered for using stem cells in treating COVID-19, which were aimed at using different cell sources, dosages and, most importantly, various targeted patient groups. The possibilities of stem cell use in COVID-19 patients, as well as relevant challenges were discussed in this brief review. This review concluded that there are certain difficulties with MSCs therapy that must be resolved prior to commencing treatment. These included the need to improve homing efficiency of MSCs, the long-time of producing a clinically meaningful number of autologous stem cells; in addition, not all cases are good candidates for MSCs treatment; lastly, the absence of a standardized treatment creates differences in the effective parameters in MSCs therapy. It is hoped that in the near future, the combined efforts of global researches would better realize the actual therapeutic benefits of MSCs-based therapies in managing patients with COVID-19.

Keywords:
Clinical trials, COVID-19, mesenchymal stem cells, stem cell therapy, MSC


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Mesenchymal stem cell-based therapies as a recent treatment modality in COVID-19: possibilities and challenges


Authors
Gamal Kenawy
Professor, Medical Biochemistry and Molecular Biology, Riyadh Elm University, Riyadh Colleges of Dentistry and Pharmacy, Qurtubah, Riyadh, Saudi Arabia
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Yasmeen Alfouzan
Student, College of Medicine, Qassim University, Buraydah, Saudi Arabia
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Maryam Bajaber
Student, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
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Hadeel Alqasem
Student, Department of Respiratory Care, College of Applied Medical Sciences- Jubail, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
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Shaimaa Banaji
Student, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
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Nurah Alkhteeb
Student, College of Medicine, King Faisal University, Hofuf, Saudi Arabia.
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Correspondence to:
. Yasmeen Alfouzan, College of Medicine, Qassim University, Buraydah, Saudi Arabia.; yasmeen.abdulaziz.f@gmail.com

Publication history
Received 15 Jan 2022
Accepted 14 Mar 2022
Published online 03 Jun 2022
Published in print 04 Jun 2022

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Pubmed Style

Kenawy G, Alfouzan Y, Bajaber M, Alqasem H, Banaji S, Alkhteeb N. Mesenchymal stem cell-based therapies as a recent treatment modality in COVID-19: possibilities and challenges. IJMDC. 2022; 6(6): 875-881. doi:10.24911/IJMDC.51-1642074541


Web Style

Kenawy G, Alfouzan Y, Bajaber M, Alqasem H, Banaji S, Alkhteeb N. Mesenchymal stem cell-based therapies as a recent treatment modality in COVID-19: possibilities and challenges. https://www.ijmdc.com/?mno=3491 [Access: August 18, 2022]. doi:10.24911/IJMDC.51-1642074541


AMA (American Medical Association) Style

Kenawy G, Alfouzan Y, Bajaber M, Alqasem H, Banaji S, Alkhteeb N. Mesenchymal stem cell-based therapies as a recent treatment modality in COVID-19: possibilities and challenges. IJMDC. 2022; 6(6): 875-881. doi:10.24911/IJMDC.51-1642074541


Vancouver/ICMJE Style

Kenawy G, Alfouzan Y, Bajaber M, Alqasem H, Banaji S, Alkhteeb N. Mesenchymal stem cell-based therapies as a recent treatment modality in COVID-19: possibilities and challenges. IJMDC. (2022), [cited August 18, 2022]; 6(6): 875-881. doi:10.24911/IJMDC.51-1642074541


Harvard Style

Kenawy, G., Alfouzan, . Y., Bajaber, . M., Alqasem, . H., Banaji, . S. & Alkhteeb, . N. (2022) Mesenchymal stem cell-based therapies as a recent treatment modality in COVID-19: possibilities and challenges. IJMDC, 6 (6), 875-881. doi:10.24911/IJMDC.51-1642074541


Turabian Style

Kenawy, Gamal, Yasmeen Alfouzan, Maryam Bajaber, Hadeel Alqasem, Shaimaa Banaji, and Nurah Alkhteeb. 2022. Mesenchymal stem cell-based therapies as a recent treatment modality in COVID-19: possibilities and challenges. International Journal of Medicine in Developing Countries, 6 (6), 875-881. doi:10.24911/IJMDC.51-1642074541


Chicago Style

Kenawy, Gamal, Yasmeen Alfouzan, Maryam Bajaber, Hadeel Alqasem, Shaimaa Banaji, and Nurah Alkhteeb. "Mesenchymal stem cell-based therapies as a recent treatment modality in COVID-19: possibilities and challenges." International Journal of Medicine in Developing Countries 6 (2022), 875-881. doi:10.24911/IJMDC.51-1642074541


MLA (The Modern Language Association) Style

Kenawy, Gamal, Yasmeen Alfouzan, Maryam Bajaber, Hadeel Alqasem, Shaimaa Banaji, and Nurah Alkhteeb. "Mesenchymal stem cell-based therapies as a recent treatment modality in COVID-19: possibilities and challenges." International Journal of Medicine in Developing Countries 6.6 (2022), 875-881. Print. doi:10.24911/IJMDC.51-1642074541


APA (American Psychological Association) Style

Kenawy, G., Alfouzan, . Y., Bajaber, . M., Alqasem, . H., Banaji, . S. & Alkhteeb, . N. (2022) Mesenchymal stem cell-based therapies as a recent treatment modality in COVID-19: possibilities and challenges. International Journal of Medicine in Developing Countries, 6 (6), 875-881. doi:10.24911/IJMDC.51-1642074541


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