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2026, Vol: 10, Issue: 6
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Review Article
Online Published: 27 Apr 2026
 


Minimally invasive versus open pancreatectomies for pancreatic neuroendocrine tumors: a systematic review and meta analysis

Hasan I. Matar, Ghina Abdulrahman Zakri, Releman Hassan Alsharif, Remas Dafer Abdullah A. L. Mohammed, Mazin Abdelgadir, Norah Ibrahim Abdu Asiri, Jamal Alfaify, Roza Alshaikh, Thamer A. Sarhan, Abdulaziz Alhagbani.


Abstract
Pancreatic neuroendocrine tumors (PNETs) are rare neoplasms that are frequently diagnosed at a late stage, particularly the non-functional subtypes that lack hormone-related symptoms. Reported risk factors include diabetes mellitus and a family history of malignancy. Minimally invasive surgery (MIS) has gained acceptance as an alternative to open pancreatectomy, with evidence suggesting comparable perioperative and oncologic outcomes, especially for distal pancreatic tumors; however, data remain limited regarding right-sided tumors and long-term outcomes, warranting further investigation. This systematic review and meta-analysis were conducted according to PRISMA guidelines. A comprehensive literature search identified comparative studies evaluating minimally invasive versus open pancreatectomy for PNETs. Study selection, data extraction, and quality assessment were performed independently. A random-effects meta-analysis was conducted using R software to calculate pooled risk ratios (RRs), mean differences (MDs), and measures of heterogeneity. Eight cohort studies published between 2017 and 2022 were included, comprising 2,210 patients (934 MIS and 1,253 open). Meta-analysis demonstrated no significant differences between MIS and open surgery in post operative pancreatic fistula (RR = 1.07), hemorrhage (RR = 0.86), overall morbidity (RR = 0.87), or R0 resection rate (RR = 1.04). MIS was associated with significantly lower recurrence (RR = 0.28, P = 0.005), shorter length of hospital stay (MD = –2.97 days, p < 0.0001), and reduced intraoperative blood loss (MD = –199.4 mL, p = 0.018). All included studies were rated as “good” quality using NIH assessment criteria. In conclusion, minimally invasive distal pancreatectomy is a safe and effective approach for selected patients with PNETs, offering outcomes comparable to open surgery while providing advantages in recurrence, blood loss, and hospitalization.

Key words: Pancreatic neuroendocrine tumors, open, Minimally


 
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How to Cite this Article
Pubmed Style

Matar HI, Zakri GA, Alsharif RH, , Abdelgadir M, Asiri NIA, Alfaify J, Alshaikh R, Sarhan TA, Alhagbani A. Minimally invasive versus open pancreatectomies for pancreatic neuroendocrine tumors: a systematic review and meta analysis. IJMDC. 2026; 10(5): 1449-1460. doi:10.24911/IJMDC.51-1771664548

Web Style

Matar HI, Zakri GA, Alsharif RH, , Abdelgadir M, Asiri NIA, Alfaify J, Alshaikh R, Sarhan TA, Alhagbani A. Minimally invasive versus open pancreatectomies for pancreatic neuroendocrine tumors: a systematic review and meta analysis. https://www.ijmdc.com/?mno=311275 [Access: May 07, 2026]. doi:10.24911/IJMDC.51-1771664548

AMA (American Medical Association) Style

Matar HI, Zakri GA, Alsharif RH, , Abdelgadir M, Asiri NIA, Alfaify J, Alshaikh R, Sarhan TA, Alhagbani A. Minimally invasive versus open pancreatectomies for pancreatic neuroendocrine tumors: a systematic review and meta analysis. IJMDC. 2026; 10(5): 1449-1460. doi:10.24911/IJMDC.51-1771664548


Vancouver/ICMJE Style

Matar HI, Zakri GA, Alsharif RH, , Abdelgadir M, Asiri NIA, Alfaify J, Alshaikh R, Sarhan TA, Alhagbani A. Minimally invasive versus open pancreatectomies for pancreatic neuroendocrine tumors: a systematic review and meta analysis. IJMDC. (2026), [cited May 07, 2026]; 10(5): 1449-1460. doi:10.24911/IJMDC.51-1771664548


Harvard Style

Matar, H. I., Zakri, . G. A., Alsharif, . R. H., , Abdelgadir, . M., Asiri, . N. I. A., Alfaify, . J., Alshaikh, . R., Sarhan, . T. A. & Alhagbani, . A. (2026) Minimally invasive versus open pancreatectomies for pancreatic neuroendocrine tumors: a systematic review and meta analysis. IJMDC, 10 (5), 1449-1460. doi:10.24911/IJMDC.51-1771664548


Turabian Style

Matar, Hasan I., Ghina Abdulrahman Zakri, Releman Hassan Alsharif, Remas Dafer Abdullah A. L. Mohammed, Mazin Abdelgadir, Norah Ibrahim Abdu Asiri, Jamal Alfaify, Roza Alshaikh, Thamer A. Sarhan, and Abdulaziz Alhagbani. 2026. Minimally invasive versus open pancreatectomies for pancreatic neuroendocrine tumors: a systematic review and meta analysis. International Journal of Medicine in Developing Countries, 10 (5), 1449-1460. doi:10.24911/IJMDC.51-1771664548


Chicago Style

Matar, Hasan I., Ghina Abdulrahman Zakri, Releman Hassan Alsharif, Remas Dafer Abdullah A. L. Mohammed, Mazin Abdelgadir, Norah Ibrahim Abdu Asiri, Jamal Alfaify, Roza Alshaikh, Thamer A. Sarhan, and Abdulaziz Alhagbani. "Minimally invasive versus open pancreatectomies for pancreatic neuroendocrine tumors: a systematic review and meta analysis." International Journal of Medicine in Developing Countries 10 (2026), 1449-1460. doi:10.24911/IJMDC.51-1771664548


MLA (The Modern Language Association) Style

Matar, Hasan I., Ghina Abdulrahman Zakri, Releman Hassan Alsharif, Remas Dafer Abdullah A. L. Mohammed, Mazin Abdelgadir, Norah Ibrahim Abdu Asiri, Jamal Alfaify, Roza Alshaikh, Thamer A. Sarhan, and Abdulaziz Alhagbani. "Minimally invasive versus open pancreatectomies for pancreatic neuroendocrine tumors: a systematic review and meta analysis." International Journal of Medicine in Developing Countries 10.5 (2026), 1449-1460. Print. doi:10.24911/IJMDC.51-1771664548


APA (American Psychological Association) Style

Matar, H. I., Zakri, . G. A., Alsharif, . R. H., , Abdelgadir, . M., Asiri, . N. I. A., Alfaify, . J., Alshaikh, . R., Sarhan, . T. A. & Alhagbani, . A. (2026) Minimally invasive versus open pancreatectomies for pancreatic neuroendocrine tumors: a systematic review and meta analysis. International Journal of Medicine in Developing Countries, 10 (5), 1449-1460. doi:10.24911/IJMDC.51-1771664548




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