Effectiveness of apixaban in warfarin hepatotoxicity: A case report

Ali A Alaklabi; Abdullah M Alotaibi; Abdulmalik S Alotaibi; M Alessa; Hanan Abdulrahman Habeeb

doi:10.24911/IJMDC.1.2.8

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Case Report
Online Published: 06 Jan 2018

IJMDC. 2017; 1(2): 85-87

doi: 10.24911/IJMDC.1.2.8

Effectiveness of apixaban in warfarin hepatotoxicity: A case report

Ali A Alaklabi, Abdullah M Alotaibi, Abdulmalik S Alotaibi, M Alessa, Hanan Abdulrahman Habeeb.

Abstract
Background: Apixaban is a direct and competitive inhibitor of factor Xa. It has been shown to be effective and safe to Prevent Stroke in Atrial Fibrillation Patients. This study is a case report of warfarin-induced cholestasis that occurred one week after starting warfarin for deep venous thrombosis, in which the cholestasis improved after the offending drug was stopped but worsened after beginning apixaban.
Case Presentation: We presented a case of 79-year-old woman, she was presented to the emergency depart¬ment with a chief complaint of left lower limb swelling of 3 days duration. On physical examination, her left lower limb was swollen, warm, and tender. Venous Doppler ultrasound showed extensive deep venous throm¬bosis and anticoagulation with unfractionated heparin and warfarin 7 mg initiated.
Conclusion: Apixaban should be avoided in patients with warfarin-induced cholestasis.

Key words: Warfarin, apixaban, hepatotoxicity, anticoagulant, thrombosis, case report.

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Pubmed Style

Alaklabi AA, Alotaibi AM, Alotaibi AS, Alessa M, Habeeb HA. Effectiveness of apixaban in warfarin hepatotoxicity: A case report. IJMDC. 2017; 1(2): 85-87. doi:10.24911/IJMDC.1.2.8

Web Style

Alaklabi AA, Alotaibi AM, Alotaibi AS, Alessa M, Habeeb HA. Effectiveness of apixaban in warfarin hepatotoxicity: A case report. https://www.ijmdc.com/?mno=287580 [Access: January 14, 2025]. doi:10.24911/IJMDC.1.2.8

AMA (American Medical Association) Style

Alaklabi AA, Alotaibi AM, Alotaibi AS, Alessa M, Habeeb HA. Effectiveness of apixaban in warfarin hepatotoxicity: A case report. IJMDC. 2017; 1(2): 85-87. doi:10.24911/IJMDC.1.2.8

Vancouver/ICMJE Style

Alaklabi AA, Alotaibi AM, Alotaibi AS, Alessa M, Habeeb HA. Effectiveness of apixaban in warfarin hepatotoxicity: A case report. IJMDC. (2017), [cited January 14, 2025]; 1(2): 85-87. doi:10.24911/IJMDC.1.2.8

Harvard Style

Alaklabi, A. A., Alotaibi, . A. M., Alotaibi, . A. S., Alessa, . M. & Habeeb, . H. A. (2017) Effectiveness of apixaban in warfarin hepatotoxicity: A case report. IJMDC, 1 (2), 85-87. doi:10.24911/IJMDC.1.2.8

Turabian Style

Alaklabi, Ali A, Abdullah M Alotaibi, Abdulmalik S Alotaibi, M Alessa, and Hanan Abdulrahman Habeeb. 2017. Effectiveness of apixaban in warfarin hepatotoxicity: A case report. International Journal of Medicine in Developing Countries, 1 (2), 85-87. doi:10.24911/IJMDC.1.2.8

Chicago Style

Alaklabi, Ali A, Abdullah M Alotaibi, Abdulmalik S Alotaibi, M Alessa, and Hanan Abdulrahman Habeeb. "Effectiveness of apixaban in warfarin hepatotoxicity: A case report." International Journal of Medicine in Developing Countries 1 (2017), 85-87. doi:10.24911/IJMDC.1.2.8

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Alaklabi, A. A., Alotaibi, . A. M., Alotaibi, . A. S., Alessa, . M. & Habeeb, . H. A. (2017) Effectiveness of apixaban in warfarin hepatotoxicity: A case report. International Journal of Medicine in Developing Countries, 1 (2), 85-87. doi:10.24911/IJMDC.1.2.8

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