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Review Article
Online Published: 05 Oct 2025
 


Comparison of 308 nm Excimer Laser versus 308 nm Excimer Lamp in Treatment of Vitiligo: A Systematic Review and Meta-Analysis

Hosam Hadi Awaji, Basel H Bakhamees, Renad Lafi Alanazi, Hisham Sulaiman Alqifari, Horyah Saeed Bakhsh, Mariyah Ahmed A Alyahya, Abdullah Ahmed Alhejaily, Abdulrahman Omar A Alfakhri, Ali Mohammed Taher Sumayli, Juri Abdullah Alghofaili, Daad Abdullah Alsubaie, Saja Abdullatif Albenayyan.


Abstract
Vitiligo is a persistent autoimmune disorder characterized by depigmentation of the skin. Both the 308 nm Excimer Laser and Lamp have been adopted for the treatment of vitiligo, but a direct comparison of their efficacy and safety is lacking. This systematic review and meta-analysis was conducted to identify randomized controlled trials (RCTs) comparing both modalities in the management of vitiligo. Primary outcomes included overall repigmentation, ≥75% repigmentation, ≥50% repigmentation, and mean repigmentation score. Secondary outcomes included adverse effects. Three RCTs involving 168 patients with 421 vitiligo lesions were included in the analysis. The pooled results showed no statistically significant difference between the two treatment modalities in terms of overall repigmentation, ≥75% repigmentation, ≥50% repigmentation, mean repigmentation score, or adverse effects.Both approaches appear to be effective and safe for the treatment of vitiligo. The choice between the two modalities may depend on factors such as cost, availability, and patient preference. Further research is warranted to identify potential subgroups of patients who may benefit more from one modality over the other.

Key words: Vitiligo; Excimer Laser; Excimer Lamp; Repigmentation


 
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How to Cite this Article
Pubmed Style

Awaji HH, Bakhamees BH, Alanazi RL, Alqifari HS, Bakhsh HS, Alyahya MAA, Alhejaily AA, Alfakhri AOA, Sumayli AMT, Alghofaili JA, Alsubaie DA, Albenayyan SA. Comparison of 308 nm Excimer Laser versus 308 nm Excimer Lamp in Treatment of Vitiligo: A Systematic Review and Meta-Analysis. IJMDC. Online First: 05 Oct, 2025. doi:10.24911/IJMDC.51-1753713546

Web Style

Awaji HH, Bakhamees BH, Alanazi RL, Alqifari HS, Bakhsh HS, Alyahya MAA, Alhejaily AA, Alfakhri AOA, Sumayli AMT, Alghofaili JA, Alsubaie DA, Albenayyan SA. Comparison of 308 nm Excimer Laser versus 308 nm Excimer Lamp in Treatment of Vitiligo: A Systematic Review and Meta-Analysis. https://www.ijmdc.com/?mno=273878 [Access: October 13, 2025]. doi:10.24911/IJMDC.51-1753713546

AMA (American Medical Association) Style

Awaji HH, Bakhamees BH, Alanazi RL, Alqifari HS, Bakhsh HS, Alyahya MAA, Alhejaily AA, Alfakhri AOA, Sumayli AMT, Alghofaili JA, Alsubaie DA, Albenayyan SA. Comparison of 308 nm Excimer Laser versus 308 nm Excimer Lamp in Treatment of Vitiligo: A Systematic Review and Meta-Analysis. IJMDC. Online First: 05 Oct, 2025. doi:10.24911/IJMDC.51-1753713546


Vancouver/ICMJE Style

Awaji HH, Bakhamees BH, Alanazi RL, Alqifari HS, Bakhsh HS, Alyahya MAA, Alhejaily AA, Alfakhri AOA, Sumayli AMT, Alghofaili JA, Alsubaie DA, Albenayyan SA. Comparison of 308 nm Excimer Laser versus 308 nm Excimer Lamp in Treatment of Vitiligo: A Systematic Review and Meta-Analysis. IJMDC, [cited October 13, 2025]; Online First: 05 Oct, 2025. doi:10.24911/IJMDC.51-1753713546


Harvard Style

Awaji, H. H., Bakhamees, . B. H., Alanazi, . R. L., Alqifari, . H. S., Bakhsh, . H. S., Alyahya, . M. A. A., Alhejaily, . A. A., Alfakhri, . A. O. A., Sumayli, . A. M. T., Alghofaili, . J. A., Alsubaie, . D. A. & Albenayyan, . S. A. (2025) Comparison of 308 nm Excimer Laser versus 308 nm Excimer Lamp in Treatment of Vitiligo: A Systematic Review and Meta-Analysis. IJMDC, Online First: 05 Oct, 2025. doi:10.24911/IJMDC.51-1753713546


Turabian Style

Awaji, Hosam Hadi, Basel H Bakhamees, Renad Lafi Alanazi, Hisham Sulaiman Alqifari, Horyah Saeed Bakhsh, Mariyah Ahmed A Alyahya, Abdullah Ahmed Alhejaily, Abdulrahman Omar A Alfakhri, Ali Mohammed Taher Sumayli, Juri Abdullah Alghofaili, Daad Abdullah Alsubaie, and Saja Abdullatif Albenayyan. 2025. Comparison of 308 nm Excimer Laser versus 308 nm Excimer Lamp in Treatment of Vitiligo: A Systematic Review and Meta-Analysis. International Journal of Medicine in Developing Countries, Online First: 05 Oct, 2025. doi:10.24911/IJMDC.51-1753713546


Chicago Style

Awaji, Hosam Hadi, Basel H Bakhamees, Renad Lafi Alanazi, Hisham Sulaiman Alqifari, Horyah Saeed Bakhsh, Mariyah Ahmed A Alyahya, Abdullah Ahmed Alhejaily, Abdulrahman Omar A Alfakhri, Ali Mohammed Taher Sumayli, Juri Abdullah Alghofaili, Daad Abdullah Alsubaie, and Saja Abdullatif Albenayyan. "Comparison of 308 nm Excimer Laser versus 308 nm Excimer Lamp in Treatment of Vitiligo: A Systematic Review and Meta-Analysis." International Journal of Medicine in Developing Countries Online First: 05 Oct, 2025. doi:10.24911/IJMDC.51-1753713546


MLA (The Modern Language Association) Style

Awaji, Hosam Hadi, Basel H Bakhamees, Renad Lafi Alanazi, Hisham Sulaiman Alqifari, Horyah Saeed Bakhsh, Mariyah Ahmed A Alyahya, Abdullah Ahmed Alhejaily, Abdulrahman Omar A Alfakhri, Ali Mohammed Taher Sumayli, Juri Abdullah Alghofaili, Daad Abdullah Alsubaie, and Saja Abdullatif Albenayyan. "Comparison of 308 nm Excimer Laser versus 308 nm Excimer Lamp in Treatment of Vitiligo: A Systematic Review and Meta-Analysis." International Journal of Medicine in Developing Countries Online First: 05 Oct, 2025. Web. 13 Oct 2025 doi:10.24911/IJMDC.51-1753713546


APA (American Psychological Association) Style

Awaji, H. H., Bakhamees, . B. H., Alanazi, . R. L., Alqifari, . H. S., Bakhsh, . H. S., Alyahya, . M. A. A., Alhejaily, . A. A., Alfakhri, . A. O. A., Sumayli, . A. M. T., Alghofaili, . J. A., Alsubaie, . D. A. & Albenayyan, . S. A. (2025) Comparison of 308 nm Excimer Laser versus 308 nm Excimer Lamp in Treatment of Vitiligo: A Systematic Review and Meta-Analysis. International Journal of Medicine in Developing Countries, Online First: 05 Oct, 2025. doi:10.24911/IJMDC.51-1753713546




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