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2026, Vol: 10, Issue: 4
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Case Report
Online Published: 04 Jun 2025
 


A hypersensitivity reaction to insulin glargine in a patient with type 2 diabetes

Rehab Khaleel Alenazy, Ahmad Mohedeen Aldawalibi, Mohammed Ali Alghamdi, Nawt Mohammed Alsarrah, Tahani Mohammed Alshammari, Asma Abdullah Aloufi, Laila Mehda Alshammari, Hadeel Abdullah Mohammed Alenazi.


Abstract
Background: Insulin is essential for managing diabetes mellitus (DM), and while hypersensitivity reactions to insulin are uncommon, they have been observed since the introduction of animal-derived insulin. The incidence of such reactions has decreased with the advent of human insulin produced through recombinant DNA technology. This case study explores a rare hypersensitivity reaction to insulin glargine in a patient with Type-2 DM.
Case Presentation: A 64-year-old male with Type-2 DM and impaired kidney function experienced an immediate hypersensitivity reaction (Type-1) at the subcutaneous injection sites of insulin glargine. Despite receiving the prescribed dose under medical supervision, the patient exhibited widespread erythema, rashes, and itching at the injection sites.
Conclusion: This case highlights the complexities of managing hypersensitivity reactions to specific insulin formulations, such as insulin glargine. Close monitoring and individualized treatment strategies are crucial to balance effective glycemic control with minimizing adverse reactions in diabetic patients.

Key words: Keywords: Insulin, Type 2 Diabetes Mellitus, Insulin Glargine, Hypersensitivity Reaction, Erythema, Glycemic Control, Case Report.


 
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How to Cite this Article
Pubmed Style

Alenazy RK, Aldawalibi AM, Alghamdi MA, Alsarrah NM, Alshammari TM, Aloufi AA, Alshammari LM, Alenazi HAM. A hypersensitivity reaction to insulin glargine in a patient with type 2 diabetes. IJMDC. 2025; 9(5): 1236-1239. doi:10.24911/IJMDC.51-1741718681

Web Style

Alenazy RK, Aldawalibi AM, Alghamdi MA, Alsarrah NM, Alshammari TM, Aloufi AA, Alshammari LM, Alenazi HAM. A hypersensitivity reaction to insulin glargine in a patient with type 2 diabetes. https://www.ijmdc.com/?mno=246972 [Access: October 14, 2025]. doi:10.24911/IJMDC.51-1741718681

AMA (American Medical Association) Style

Alenazy RK, Aldawalibi AM, Alghamdi MA, Alsarrah NM, Alshammari TM, Aloufi AA, Alshammari LM, Alenazi HAM. A hypersensitivity reaction to insulin glargine in a patient with type 2 diabetes. IJMDC. 2025; 9(5): 1236-1239. doi:10.24911/IJMDC.51-1741718681


Vancouver/ICMJE Style

Alenazy RK, Aldawalibi AM, Alghamdi MA, Alsarrah NM, Alshammari TM, Aloufi AA, Alshammari LM, Alenazi HAM. A hypersensitivity reaction to insulin glargine in a patient with type 2 diabetes. IJMDC. (2025), [cited October 14, 2025]; 9(5): 1236-1239. doi:10.24911/IJMDC.51-1741718681


Harvard Style

Alenazy, R. K., Aldawalibi, . A. M., Alghamdi, . M. A., Alsarrah, . N. M., Alshammari, . T. M., Aloufi, . A. A., Alshammari, . L. M. & Alenazi, . H. A. M. (2025) A hypersensitivity reaction to insulin glargine in a patient with type 2 diabetes. IJMDC, 9 (5), 1236-1239. doi:10.24911/IJMDC.51-1741718681


Turabian Style

Alenazy, Rehab Khaleel, Ahmad Mohedeen Aldawalibi, Mohammed Ali Alghamdi, Nawt Mohammed Alsarrah, Tahani Mohammed Alshammari, Asma Abdullah Aloufi, Laila Mehda Alshammari, and Hadeel Abdullah Mohammed Alenazi. 2025. A hypersensitivity reaction to insulin glargine in a patient with type 2 diabetes. International Journal of Medicine in Developing Countries, 9 (5), 1236-1239. doi:10.24911/IJMDC.51-1741718681


Chicago Style

Alenazy, Rehab Khaleel, Ahmad Mohedeen Aldawalibi, Mohammed Ali Alghamdi, Nawt Mohammed Alsarrah, Tahani Mohammed Alshammari, Asma Abdullah Aloufi, Laila Mehda Alshammari, and Hadeel Abdullah Mohammed Alenazi. "A hypersensitivity reaction to insulin glargine in a patient with type 2 diabetes." International Journal of Medicine in Developing Countries 9 (2025), 1236-1239. doi:10.24911/IJMDC.51-1741718681


MLA (The Modern Language Association) Style

Alenazy, Rehab Khaleel, Ahmad Mohedeen Aldawalibi, Mohammed Ali Alghamdi, Nawt Mohammed Alsarrah, Tahani Mohammed Alshammari, Asma Abdullah Aloufi, Laila Mehda Alshammari, and Hadeel Abdullah Mohammed Alenazi. "A hypersensitivity reaction to insulin glargine in a patient with type 2 diabetes." International Journal of Medicine in Developing Countries 9.5 (2025), 1236-1239. Print. doi:10.24911/IJMDC.51-1741718681


APA (American Psychological Association) Style

Alenazy, R. K., Aldawalibi, . A. M., Alghamdi, . M. A., Alsarrah, . N. M., Alshammari, . T. M., Aloufi, . A. A., Alshammari, . L. M. & Alenazi, . H. A. M. (2025) A hypersensitivity reaction to insulin glargine in a patient with type 2 diabetes. International Journal of Medicine in Developing Countries, 9 (5), 1236-1239. doi:10.24911/IJMDC.51-1741718681




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