E-ISSN 1658-7820
 
2025, Vol: 9, Issue: 3
9 / 3Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Review Article
Online Published: 23 Jan 2025
 


Exploring the efficacy and safety of new oral anticoagulants in the management of atrial fibrillation in obese patients: a systematic review

Thamer Alhumodi Alenazi, Renad Majed A. Alqurashi, Saeed Ali Alzahrani, Abdullah Hassan A. Alzubaidi, Faisal Majed A. Alkhannani, Mohammad Abdulaziz H. Bin Oti, Mrooj Mabruk Almutairi, Noor Saeed Mahdi Abdulla Mahdi, Wala Salem Fallatah, Mohammed Faisal Saleh Alajmi.


Abstract
We evaluated the available evidence on the performance of non-vitamin K oral anticoagulants (NOACs) and direct oral anticoagulants (DOACs) in obese populations with AF using a total of 732 pertinent publications found after a comprehensive search across four databases. After eliminating duplicates using Rayyan QCRI and checking for relevance, we examined 87 full-text publications; finally, seven studies met the inclusion requirements. We included seven studies with a total of 68,835 AF patients, and the majority, 61,171 (88.9%) were males. DOACs and NOACs work just as well and are just as safe as warfarin in obese people with atrial fibrillation. They lower the risk of stroke and thromboembolic complications without making bleeding problems much worse. NOACs, such as apixaban and rivaroxaban, showed favorable outcomes, including improved survival rates and reduced severe bleeding risks, particularly in morbidly obese individuals. DOACs and NOACs are effective and safe alternatives to warfarin for obese patients with Atrial Fibrillation (AF), offering comparable stroke prevention and reduced bleeding risks. We support their widespread use, including in morbid obesity, but personalized approaches may be necessary for optimal outcomes. Further research on standardized obesity definitions, extreme Body Mass Index (BMI) populations, and long-term outcomes is essential to enhance anticoagulation strategies for this high-risk group.

Key words: Direct Oral Anticoagulants; Non-vitamin K Oral Anticoagulants; Atrial Fibrillation; Obesity; Morbid Obesity; Safety; Effectiveness; Systematic review.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Thamer Alhumodi Alenazi
Articles by Renad Majed A. Alqurashi
Articles by Saeed Ali Alzahrani
Articles by Abdullah Hassan A. Alzubaidi
Articles by Faisal Majed A. Alkhannani
Articles by Mohammad Abdulaziz H. Bin Oti
Articles by Mrooj Mabruk Almutairi
Articles by Noor Saeed Mahdi Abdulla Mahdi
Articles by Wala Salem Fallatah
Articles by Mohammed Faisal Saleh Alajmi
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Alenazi TA, Alqurashi RMA, Alzahrani SA, Alzubaidi AHA, Alkhannani FMA, Oti MAHB, Almutairi MM, Mahdi NSMA, Fallatah WS, Alajmi MFS. Exploring the efficacy and safety of new oral anticoagulants in the management of atrial fibrillation in obese patients: a systematic review. IJMDC. 2025; 9(3): 756-762. doi:10.24911/IJMDC.51-1734640741

Web Style

Alenazi TA, Alqurashi RMA, Alzahrani SA, Alzubaidi AHA, Alkhannani FMA, Oti MAHB, Almutairi MM, Mahdi NSMA, Fallatah WS, Alajmi MFS. Exploring the efficacy and safety of new oral anticoagulants in the management of atrial fibrillation in obese patients: a systematic review. https://www.ijmdc.com/?mno=233812 [Access: May 06, 2025]. doi:10.24911/IJMDC.51-1734640741

AMA (American Medical Association) Style

Alenazi TA, Alqurashi RMA, Alzahrani SA, Alzubaidi AHA, Alkhannani FMA, Oti MAHB, Almutairi MM, Mahdi NSMA, Fallatah WS, Alajmi MFS. Exploring the efficacy and safety of new oral anticoagulants in the management of atrial fibrillation in obese patients: a systematic review. IJMDC. 2025; 9(3): 756-762. doi:10.24911/IJMDC.51-1734640741


Vancouver/ICMJE Style

Alenazi TA, Alqurashi RMA, Alzahrani SA, Alzubaidi AHA, Alkhannani FMA, Oti MAHB, Almutairi MM, Mahdi NSMA, Fallatah WS, Alajmi MFS. Exploring the efficacy and safety of new oral anticoagulants in the management of atrial fibrillation in obese patients: a systematic review. IJMDC. (2025), [cited May 06, 2025]; 9(3): 756-762. doi:10.24911/IJMDC.51-1734640741


Harvard Style

Alenazi, T. A., Alqurashi, . R. M. A., Alzahrani, . S. A., Alzubaidi, . A. H. A., Alkhannani, . F. M. A., Oti, . M. A. H. B., Almutairi, . M. M., Mahdi, . N. S. M. A., Fallatah, . W. S. & Alajmi, . M. F. S. (2025) Exploring the efficacy and safety of new oral anticoagulants in the management of atrial fibrillation in obese patients: a systematic review. IJMDC, 9 (3), 756-762. doi:10.24911/IJMDC.51-1734640741


Turabian Style

Alenazi, Thamer Alhumodi, Renad Majed A. Alqurashi, Saeed Ali Alzahrani, Abdullah Hassan A. Alzubaidi, Faisal Majed A. Alkhannani, Mohammad Abdulaziz H. Bin Oti, Mrooj Mabruk Almutairi, Noor Saeed Mahdi Abdulla Mahdi, Wala Salem Fallatah, and Mohammed Faisal Saleh Alajmi. 2025. Exploring the efficacy and safety of new oral anticoagulants in the management of atrial fibrillation in obese patients: a systematic review. International Journal of Medicine in Developing Countries, 9 (3), 756-762. doi:10.24911/IJMDC.51-1734640741


Chicago Style

Alenazi, Thamer Alhumodi, Renad Majed A. Alqurashi, Saeed Ali Alzahrani, Abdullah Hassan A. Alzubaidi, Faisal Majed A. Alkhannani, Mohammad Abdulaziz H. Bin Oti, Mrooj Mabruk Almutairi, Noor Saeed Mahdi Abdulla Mahdi, Wala Salem Fallatah, and Mohammed Faisal Saleh Alajmi. "Exploring the efficacy and safety of new oral anticoagulants in the management of atrial fibrillation in obese patients: a systematic review." International Journal of Medicine in Developing Countries 9 (2025), 756-762. doi:10.24911/IJMDC.51-1734640741


MLA (The Modern Language Association) Style

Alenazi, Thamer Alhumodi, Renad Majed A. Alqurashi, Saeed Ali Alzahrani, Abdullah Hassan A. Alzubaidi, Faisal Majed A. Alkhannani, Mohammad Abdulaziz H. Bin Oti, Mrooj Mabruk Almutairi, Noor Saeed Mahdi Abdulla Mahdi, Wala Salem Fallatah, and Mohammed Faisal Saleh Alajmi. "Exploring the efficacy and safety of new oral anticoagulants in the management of atrial fibrillation in obese patients: a systematic review." International Journal of Medicine in Developing Countries 9.3 (2025), 756-762. Print. doi:10.24911/IJMDC.51-1734640741


APA (American Psychological Association) Style

Alenazi, T. A., Alqurashi, . R. M. A., Alzahrani, . S. A., Alzubaidi, . A. H. A., Alkhannani, . F. M. A., Oti, . M. A. H. B., Almutairi, . M. M., Mahdi, . N. S. M. A., Fallatah, . W. S. & Alajmi, . M. F. S. (2025) Exploring the efficacy and safety of new oral anticoagulants in the management of atrial fibrillation in obese patients: a systematic review. International Journal of Medicine in Developing Countries, 9 (3), 756-762. doi:10.24911/IJMDC.51-1734640741




Most Viewed Articles
Most Accessed Articles

  • Marginal adaptation of fixed prosthodontics
    Shahad Mohammed Halawani, Sahar Amer Al-Harbi
    IJMDC. 2017; 1(2): 78-84
    » Abstract » doi: 10.24911/IJMDC.1.2.7

  • Parasites in central nervous system
    Amal Ahmed Mohamed, Asmaa Mohamed Mansour
    IJMDC. 2017; 1(2): 72-77
    » Abstract » doi: 10.24911/IJMDC.1.2.6

  • Non-diabetic retinopathy: a case report
    Hassan F. Alkwikbi, Nabil Mamon Abdelfattah, Haithem Mamon Abdelfattah
    IJMDC. 2017; 1(1): 33-37
    » Abstract » doi: 10.24911/IJMDC.1.1.6

  • Vitamin D deficiency among high school female students in Riyadh
    Sahar Mohsen Aldhafeeri, Fatemah Ibraheem Alrawaji, Abrar Mubarak Algharbi, Alanoud Abdullah Alhessan, Ayat Sami Qabaja, Ghaleah Abdulaziz Alnassar, Ghaliah Ofayn Alsulami, Mashael Belal Alrubaian, Norah Abdulaziz Alhatim, Salehah Salih Alotaibi, Zahra Ali Alkhamees
    IJMDC. 2017; 1(1): 18-23
    » Abstract » doi: 10.24911/IJMDC.1.1.4

  • Prognosis of chronic complications of diabetes mellitus (DM) after multiple events of diabetic ketoacidosis (DKA)
    Baraa Faiez Rajab, Anwar Essa Alamrim, Ali Essa Alamri
    IJMDC. 2019; 3(5): 474-479
    » Abstract » doi: 10.24911/IJMDC.51-1546551993

    •
    Most Downloaded
    Top Downloaded Articles

  • Anti-IL-17 markedly inhibited the in vitro granuloma induced by Schistosoma mansoni soluble egg antigen.
    Asmaa Ezz, Irene S. Gmail, Fatma Elzahraa H. Salem, Rabab Salama, Soad Nady
    IJMDC. 2018; 2(January 2018): 38-46
    » Abstract » doi: 10.24911/IJMDC.2.1.7

  • Vitamin D deficiency among high school female students in Riyadh
    Sahar Mohsen Aldhafeeri, Fatemah Ibraheem Alrawaji, Abrar Mubarak Algharbi, Alanoud Abdullah Alhessan, Ayat Sami Qabaja, Ghaleah Abdulaziz Alnassar, Ghaliah Ofayn Alsulami, Mashael Belal Alrubaian, Norah Abdulaziz Alhatim, Salehah Salih Alotaibi, Zahra Ali Alkhamees
    IJMDC. 2017; 1(1): 18-23
    » Abstract » doi: 10.24911/IJMDC.1.1.4

  • Antibiotic Resistance Crisis
    Nuha Saad Mobarki, Buthaina Abdullah Almerabi, Ahmad Hattan Hattan
    IJMDC. 2019; 3(6): 561-564
    » Abstract » doi: 10.24911/IJMDC.51-1549060699

  • The knowledge of mothers about children malnutrition and associated factors
    Anas Abdulrahman Aljohani, Mujahid Abdulrahman Aljohani
    IJMDC. 2020; 4(1): 7-11
    » Abstract » doi: 10.24911/IJMDC.51-1541620358

  • Knowledge and attitude of caregivers of cerebral palsy children in Riyadh city
    Abdulaziz Alruwaished, Baleegh Ali, Lubna Abdullah Alhowaimil , Abaraa adullah Alhowaimil, Najd Abdullah Alhowaimil, Aminah Alessa
    IJMDC. 2020; 4(1): 12-17
    » Abstract » doi: 10.24911/IJMDC.51-1547833051

    •
    Most Cited Articles
    Most Cited Articles

  • Antibiotic Resistance Crisis
    Nuha Saad Mobarki, Buthaina Abdullah Almerabi, Ahmad Hattan Hattan
    IJMDC. 2019; 3(6): 561-564
    » Abstract » doi: 10.24911/IJMDC.51-1549060699
    Cited : 34 times [Click to see citing articles]

  • Prevalence of depression, anxiety and stress among diabetes mellitus patients in Arar, Northern Saudi Arabia
    AMohammed Elamin Mukrim, Nujud Muteb D. Alshammari, Wurud Muteb D. Alshammari, Maali Subhi T. Alshammari, Yousef Nasif R. Alshammari, Abdulaziz Sael M. Alshammari, Maisa Hamad F. Alanazi, Abdulelah Abdulrhman F. Alzammam, Muharib Mana M. Alshammari, Slwa Khaled Abu Asyah, Aseel Jamal Alzuhayri, Mushref Saeid Alshammari
    IJMDC. 2019; 3(3): 229-233
    » Abstract » doi: 10.24911/IJMDC.51-1542576396
    Cited : 8 times [Click to see citing articles]

  • Knowledge, attitude, and practice of breast self-examination toward breast cancer among female students at King Saud University in Riyadh, Saudi Arabia
    Abdullah Nasser Alomair, Dania Ghazi Felemban, Mohannad Sami Felemban, Jameel Abdullah Awadain, Ammar Saud Altowairqi, Nawaf Fawzan Alfawzan, Fatimah Mohammed Almazayen, Abdulrahman Jalwi Korkoman, Nawaf Saad Alrusayyis
    IJMDC. 2020; 4(2): 429-434
    » Abstract » doi: 10.24911/IJMDC.51-1576668182
    Cited : 8 times [Click to see citing articles]

  • Population awareness about rheumatoid arthritis in Jazan region, Saudi Arabia
    Ahmad Ali Hazzazi, Mohssen Hassen Ageeli, Ahmed Ali Muyidi, Abdulaziz Mohammad Abulgasim, Abdullah Ahmad Yateemi, Nabil Alhakami
    IJMDC. 2020; 4(3): 668-675
    » Abstract » doi: 10.24911/IJMDC.51-1576010943
    Cited : 4 times [Click to see citing articles]

  • Prevalence and factors associated with depression among health care workers in National Guard Hospital in Riyadh, KSA
    Noor Mohammad AlFahhad
    IJMDC. 2018; 2(September 2018): 92-96
    » Abstract » doi: 10.24911/IJMDC.51-1526306040
    Cited : 4 times [Click to see citing articles]

    •

    About International Journal of Medicine in Developing Countries

    International Journal of Medicine in Developing Countries is a peer-reviewed, open access international medical journal. Journal Title Internat ... Read more.



    For best results, please use Internet Explorer or Google Chrome.

    Contact Information

    Publisher: Discover STM Publishing Ltd. 164 Moyville. Rathfarnham, Dublin, D16Y4E, Ireland

    Hours:  M-F: 7:30am - 4:30pm 

    Fax: +353 (0)1 633 5037 

    Emails:

    Journal Editorial Office:  contact@ijmdc.com

    All queries regarding the publishing or accepting of the manuscript should be directed to the Journal Editorial Office at Riyadh, Saudi Arabia. 

    Publishing and Hosting service is provided by Discover STM (Ireland):  contact@discoverpublish.com
    POLICIES & JOURNAL LINKS
    Author Login
    Reviewer Login
    About Publisher
    Advertising Policy
    Author's Rights and Obligations
    Conflict of Interest Policy
    Copyright Information
    Digital Archiving & Preservation Policies
    Editorial Policies
    Peer Review Policy
    Editorial & Peer Review Process
    License Information
    Open Access Policy
    Plagiarism Policy
    Privacy Policy
    Protection of Research Participants (Statement On Human And Animal Rights)
    Publication Ethics and Publication Malpractice Statement
    Corrections, Retractions & Expressions of Concern
    Self-Archiving Policies
    Statement of Informed Consent
    Terms of Use