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2024, Vol: 8, Issue: 11
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Original Article
Online Published: 30 Dec 2024
 


Improvement after tacrolimus ointment in patients with vernal keratoconjunctivitis

Talal A. Althomali, Lara E. Alsulimany, Yousef H. Sabbagh, Ghadi A. Althobaiti, Abdullah A. Alharbi, Rayan A. Alolayani, Raghad A. Almansouri.


Abstract
Objective: The current study aimed to assess the efficacy of tacrolimus ointment in improving symptoms and visual acuity among vernal keratoconjunctivitis (VKC) patients in Taif City, Saudi Arabia.
Methods: This was a retrospective study. Data were collected from the medical files in Tadawi Surgical Medical Complex.
Result: A total of 33 patients with VKC were treated with tacrolimus ointment. Improvement was observed in 21 patients (63.6%), one patient (3%) relapsed after initial improvement, three patients (9.1%) showed no improvement, one patient (3%) was non-compliant, and six patients (18.2%) had no follow-up data. Complications occurred in five patients (15.2%), with redness reported in three cases (60%), hyperemia and injection in one case (20%), and one case relapsing after stopping the medication. Most patients (66.7%) experienced no complications.
Conclusion: Tacrolimus ointment significantly improved symptoms in vernal VKC, with about two-thirds of patients improving. This aligns with findings from other studies demonstrating its efficacy and safety over both short- and long-term use. While some patients reported minor side effects such as redness and itching, the treatment was generally well-tolerated. Relapse rates were low, and tacrolimus was effective even in severe VKC cases where other treatments failed. These results support tacrolimus ointment as a viable option for managing VKC.

Key words: Vernal keratoconjunctivitis, tacrolimus, efficacy, improvement, Saudi Arabia


 
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How to Cite this Article
Pubmed Style

Althomali TA, Alsulimany LE, Sabbagh YH, Althobaiti GA, Alharbi AA, Alolayani RA, Almansouri RA. Improvement after tacrolimus ointment in patients with vernal keratoconjunctivitis. IJMDC. 2024; 8(11): 3156-3160. doi:10.24911/IJMDC.51-1733228984

Web Style

Althomali TA, Alsulimany LE, Sabbagh YH, Althobaiti GA, Alharbi AA, Alolayani RA, Almansouri RA. Improvement after tacrolimus ointment in patients with vernal keratoconjunctivitis. https://www.ijmdc.com/?mno=231439 [Access: January 14, 2025]. doi:10.24911/IJMDC.51-1733228984

AMA (American Medical Association) Style

Althomali TA, Alsulimany LE, Sabbagh YH, Althobaiti GA, Alharbi AA, Alolayani RA, Almansouri RA. Improvement after tacrolimus ointment in patients with vernal keratoconjunctivitis. IJMDC. 2024; 8(11): 3156-3160. doi:10.24911/IJMDC.51-1733228984


Vancouver/ICMJE Style

Althomali TA, Alsulimany LE, Sabbagh YH, Althobaiti GA, Alharbi AA, Alolayani RA, Almansouri RA. Improvement after tacrolimus ointment in patients with vernal keratoconjunctivitis. IJMDC. (2024), [cited January 14, 2025]; 8(11): 3156-3160. doi:10.24911/IJMDC.51-1733228984


Harvard Style

Althomali, T. A., Alsulimany, . L. E., Sabbagh, . Y. H., Althobaiti, . G. A., Alharbi, . A. A., Alolayani, . R. A. & Almansouri, . R. A. (2024) Improvement after tacrolimus ointment in patients with vernal keratoconjunctivitis. IJMDC, 8 (11), 3156-3160. doi:10.24911/IJMDC.51-1733228984


Turabian Style

Althomali, Talal A., Lara E. Alsulimany, Yousef H. Sabbagh, Ghadi A. Althobaiti, Abdullah A. Alharbi, Rayan A. Alolayani, and Raghad A. Almansouri. 2024. Improvement after tacrolimus ointment in patients with vernal keratoconjunctivitis. International Journal of Medicine in Developing Countries, 8 (11), 3156-3160. doi:10.24911/IJMDC.51-1733228984


Chicago Style

Althomali, Talal A., Lara E. Alsulimany, Yousef H. Sabbagh, Ghadi A. Althobaiti, Abdullah A. Alharbi, Rayan A. Alolayani, and Raghad A. Almansouri. "Improvement after tacrolimus ointment in patients with vernal keratoconjunctivitis." International Journal of Medicine in Developing Countries 8 (2024), 3156-3160. doi:10.24911/IJMDC.51-1733228984


MLA (The Modern Language Association) Style

Althomali, Talal A., Lara E. Alsulimany, Yousef H. Sabbagh, Ghadi A. Althobaiti, Abdullah A. Alharbi, Rayan A. Alolayani, and Raghad A. Almansouri. "Improvement after tacrolimus ointment in patients with vernal keratoconjunctivitis." International Journal of Medicine in Developing Countries 8.11 (2024), 3156-3160. Print. doi:10.24911/IJMDC.51-1733228984


APA (American Psychological Association) Style

Althomali, T. A., Alsulimany, . L. E., Sabbagh, . Y. H., Althobaiti, . G. A., Alharbi, . A. A., Alolayani, . R. A. & Almansouri, . R. A. (2024) Improvement after tacrolimus ointment in patients with vernal keratoconjunctivitis. International Journal of Medicine in Developing Countries, 8 (11), 3156-3160. doi:10.24911/IJMDC.51-1733228984




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