Assessment of the efficacy of mavacamten in patients with hypertrophic cardiomyopathy: a systematic review and meta-analysis

Tariq M. Shaqran; Bassam Hadi Awaji; Mohammad Hussain Alsaeed; Alaa Mansour Althobiti; Shaima Saad M. Aljohani; Khulud Saud A. Alshammari; Zahra Jameel Hasan; Fatimah Jamal Al Saeed; Abdullah Hameed Alhussain; Hisham Yousef Alouhali; Ali Ayman Almeer; Faisal Mofareh Assiri; Ahmed Maeen Al Ismail

doi:10.24911/IJMDC.51-1733079072

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Online Published: 30 Dec 2024

IJMDC. 2024; 8(11): 3335-3342

doi: 10.24911/IJMDC.51-1733079072

Assessment of the efficacy of mavacamten in patients with hypertrophic cardiomyopathy: a systematic review and meta-analysis

Tariq M. Shaqran, Bassam Hadi Awaji, Mohammad Hussain Alsaeed, Alaa Mansour Althobiti, Shaima Saad M. Aljohani, Khulud Saud A. Alshammari, Zahra Jameel Hasan, Fatimah Jamal Al Saeed, Abdullah Hameed Alhussain, Hisham Yousef Alouhali, Ali Ayman Almeer, Faisal Mofareh Assiri, Ahmed Maeen Al Ismail.

Abstract
A common genetic disorder known as hypertrophic cardiomyopathy (HCM) is distinguished by abnormal heart thickening. Traditional treatments frequently fail to meet the demands of individuals who have severe symptoms and obstructive consequences. Mavacamten, a myosin inhibitor, has shown promise in improving the quality of life, functional ability, and clinical outcomes for those with obstructive HCM. This systematic review examined the clinical outcomes associated with mavacamten. Data gathering adhered to the Cochrane Handbook for Systematic Reviews of Interventions (Version 6) and preferred reporting items for systematic reviews and meta-analyses criteria, with an emphasis on study characteristics, patient demographics, and mavacamten doses. Maximum wall thickness, left ventricular mass index (LVMI), left atrial volume index (LAVI), peak oxygen consumption, and N-terminal pro-B-type natriuretic peptide were also significant out-come markers. A total of 532 studies were initially discovered, five of which met the inclusion criteria. The sample size ranged from 54 to 251 people, with the majority aged 51 to 61 years. The study found no statistically significant changes in outcomes for LVMI (pooled mean difference 0.55, p = 0.85), LAVI (pooled mean difference −1.48, p = 0.16), or maximal wall thickness (pooled mean difference 0.12, p = 0.75). A trend toward a decrease in the septal E/e’ ratio was seen (pooled mean difference −1.98, p = 0.24), however, it was not statistically significant. These findings showed mavacamten’s potential to improve diastolic function, necessitating future research with larger sample sizes and longer follow-up timeframes.

Key words: Hypertrophic cardiomyopathy, mavacamten, myosin inhibitor, systematic review, cardiac outcomes

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Pubmed Style

Shaqran TM, Awaji BH, Alsaeed MH, Althobiti AM, Aljohani SSM, Alshammari KSA, Hasan ZJ, Saeed FJA, Alhussain AH, Alouhali HY, Almeer AA, Assiri FM, Ismail AMA. Assessment of the efficacy of mavacamten in patients with hypertrophic cardiomyopathy: a systematic review and meta-analysis. IJMDC. 2024; 8(11): 3335-3342. doi:10.24911/IJMDC.51-1733079072

Web Style

Shaqran TM, Awaji BH, Alsaeed MH, Althobiti AM, Aljohani SSM, Alshammari KSA, Hasan ZJ, Saeed FJA, Alhussain AH, Alouhali HY, Almeer AA, Assiri FM, Ismail AMA. Assessment of the efficacy of mavacamten in patients with hypertrophic cardiomyopathy: a systematic review and meta-analysis. https://www.ijmdc.com/?mno=231093 [Access: January 14, 2025]. doi:10.24911/IJMDC.51-1733079072

AMA (American Medical Association) Style

Shaqran TM, Awaji BH, Alsaeed MH, Althobiti AM, Aljohani SSM, Alshammari KSA, Hasan ZJ, Saeed FJA, Alhussain AH, Alouhali HY, Almeer AA, Assiri FM, Ismail AMA. Assessment of the efficacy of mavacamten in patients with hypertrophic cardiomyopathy: a systematic review and meta-analysis. IJMDC. 2024; 8(11): 3335-3342. doi:10.24911/IJMDC.51-1733079072

Vancouver/ICMJE Style

Shaqran TM, Awaji BH, Alsaeed MH, Althobiti AM, Aljohani SSM, Alshammari KSA, Hasan ZJ, Saeed FJA, Alhussain AH, Alouhali HY, Almeer AA, Assiri FM, Ismail AMA. Assessment of the efficacy of mavacamten in patients with hypertrophic cardiomyopathy: a systematic review and meta-analysis. IJMDC. (2024), [cited January 14, 2025]; 8(11): 3335-3342. doi:10.24911/IJMDC.51-1733079072

Harvard Style

Shaqran, T. M., Awaji, . B. H., Alsaeed, . M. H., Althobiti, . A. M., Aljohani, . S. S. M., Alshammari, . K. S. A., Hasan, . Z. J., Saeed, . F. J. A., Alhussain, . A. H., Alouhali, . H. Y., Almeer, . A. A., Assiri, . F. M. & Ismail, . A. M. A. (2024) Assessment of the efficacy of mavacamten in patients with hypertrophic cardiomyopathy: a systematic review and meta-analysis. IJMDC, 8 (11), 3335-3342. doi:10.24911/IJMDC.51-1733079072

Turabian Style

Shaqran, Tariq M., Bassam Hadi Awaji, Mohammad Hussain Alsaeed, Alaa Mansour Althobiti, Shaima Saad M. Aljohani, Khulud Saud A. Alshammari, Zahra Jameel Hasan, Fatimah Jamal Al Saeed, Abdullah Hameed Alhussain, Hisham Yousef Alouhali, Ali Ayman Almeer, Faisal Mofareh Assiri, and Ahmed Maeen Al Ismail. 2024. Assessment of the efficacy of mavacamten in patients with hypertrophic cardiomyopathy: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 8 (11), 3335-3342. doi:10.24911/IJMDC.51-1733079072

Chicago Style

Shaqran, Tariq M., Bassam Hadi Awaji, Mohammad Hussain Alsaeed, Alaa Mansour Althobiti, Shaima Saad M. Aljohani, Khulud Saud A. Alshammari, Zahra Jameel Hasan, Fatimah Jamal Al Saeed, Abdullah Hameed Alhussain, Hisham Yousef Alouhali, Ali Ayman Almeer, Faisal Mofareh Assiri, and Ahmed Maeen Al Ismail. "Assessment of the efficacy of mavacamten in patients with hypertrophic cardiomyopathy: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 8 (2024), 3335-3342. doi:10.24911/IJMDC.51-1733079072

MLA (The Modern Language Association) Style

Shaqran, Tariq M., Bassam Hadi Awaji, Mohammad Hussain Alsaeed, Alaa Mansour Althobiti, Shaima Saad M. Aljohani, Khulud Saud A. Alshammari, Zahra Jameel Hasan, Fatimah Jamal Al Saeed, Abdullah Hameed Alhussain, Hisham Yousef Alouhali, Ali Ayman Almeer, Faisal Mofareh Assiri, and Ahmed Maeen Al Ismail. "Assessment of the efficacy of mavacamten in patients with hypertrophic cardiomyopathy: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 8.11 (2024), 3335-3342. Print. doi:10.24911/IJMDC.51-1733079072

APA (American Psychological Association) Style

Shaqran, T. M., Awaji, . B. H., Alsaeed, . M. H., Althobiti, . A. M., Aljohani, . S. S. M., Alshammari, . K. S. A., Hasan, . Z. J., Saeed, . F. J. A., Alhussain, . A. H., Alouhali, . H. Y., Almeer, . A. A., Assiri, . F. M. & Ismail, . A. M. A. (2024) Assessment of the efficacy of mavacamten in patients with hypertrophic cardiomyopathy: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 8 (11), 3335-3342. doi:10.24911/IJMDC.51-1733079072

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