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2025, Vol: 9, Issue: 9
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Review Article
Online Published: 17 Dec 2024
 


Neurotoxic effects of star anise in the management of infantile colic: a systematic review of case reports

Ghadah Alswaidani, Rasha Alrashidi, Luluah Alzabni, Razan Alzamil, Sukaina Alzedany, Reem Alshammari.


Abstract
Star anise (Illicium verum) is a spice and traditional remedy wildly used for various reasons, including in the treatment of infantile colic. However, its neurotoxic effects in infants treated for colic have been reported. This review included three case reports published between the years 2004 and 2021 describing the clinical presentation, management, and outcomes of infants after exposure to star anise. The neurotoxic manifestations ranged from mild irritability and vomiting to more serious symptoms including seizures. These symptoms were primarily attributed to the contamination of Chinese star anise with Japanese star anise, which contains neurotoxins such as anisatin, neoanisatin, and pseudoanisatin. Most of the cases were treated conservatively with benzodiazepines for seizures and withdrawing the offending agent. There are no long-term neurological consequences of star anise toxicity.

Key words: Star anise, infantile colic, neurotoxicity, herbal toxicity, review article


 
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How to Cite this Article
Pubmed Style

Alswaidani G, Alrashidi R, Alzabni L, Alzamil R, Alzedany S, Alshammari R. Neurotoxic effects of star anise in the management of infantile colic: a systematic review of case reports. IJMDC. 2024; 8(11): 3219-3223. doi:10.24911/IJMDC.51-1731054160

Web Style

Alswaidani G, Alrashidi R, Alzabni L, Alzamil R, Alzedany S, Alshammari R. Neurotoxic effects of star anise in the management of infantile colic: a systematic review of case reports. https://www.ijmdc.com/?mno=227820 [Access: October 12, 2025]. doi:10.24911/IJMDC.51-1731054160

AMA (American Medical Association) Style

Alswaidani G, Alrashidi R, Alzabni L, Alzamil R, Alzedany S, Alshammari R. Neurotoxic effects of star anise in the management of infantile colic: a systematic review of case reports. IJMDC. 2024; 8(11): 3219-3223. doi:10.24911/IJMDC.51-1731054160


Vancouver/ICMJE Style

Alswaidani G, Alrashidi R, Alzabni L, Alzamil R, Alzedany S, Alshammari R. Neurotoxic effects of star anise in the management of infantile colic: a systematic review of case reports. IJMDC. (2024), [cited October 12, 2025]; 8(11): 3219-3223. doi:10.24911/IJMDC.51-1731054160


Harvard Style

Alswaidani, G., Alrashidi, . R., Alzabni, . L., Alzamil, . R., Alzedany, . S. & Alshammari, . R. (2024) Neurotoxic effects of star anise in the management of infantile colic: a systematic review of case reports. IJMDC, 8 (11), 3219-3223. doi:10.24911/IJMDC.51-1731054160


Turabian Style

Alswaidani, Ghadah, Rasha Alrashidi, Luluah Alzabni, Razan Alzamil, Sukaina Alzedany, and Reem Alshammari. 2024. Neurotoxic effects of star anise in the management of infantile colic: a systematic review of case reports. International Journal of Medicine in Developing Countries, 8 (11), 3219-3223. doi:10.24911/IJMDC.51-1731054160


Chicago Style

Alswaidani, Ghadah, Rasha Alrashidi, Luluah Alzabni, Razan Alzamil, Sukaina Alzedany, and Reem Alshammari. "Neurotoxic effects of star anise in the management of infantile colic: a systematic review of case reports." International Journal of Medicine in Developing Countries 8 (2024), 3219-3223. doi:10.24911/IJMDC.51-1731054160


MLA (The Modern Language Association) Style

Alswaidani, Ghadah, Rasha Alrashidi, Luluah Alzabni, Razan Alzamil, Sukaina Alzedany, and Reem Alshammari. "Neurotoxic effects of star anise in the management of infantile colic: a systematic review of case reports." International Journal of Medicine in Developing Countries 8.11 (2024), 3219-3223. Print. doi:10.24911/IJMDC.51-1731054160


APA (American Psychological Association) Style

Alswaidani, G., Alrashidi, . R., Alzabni, . L., Alzamil, . R., Alzedany, . S. & Alshammari, . R. (2024) Neurotoxic effects of star anise in the management of infantile colic: a systematic review of case reports. International Journal of Medicine in Developing Countries, 8 (11), 3219-3223. doi:10.24911/IJMDC.51-1731054160




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