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Original Article
Online Published: 10 Nov 2024
 


The association between serum uric acid levels and CVD risk factors in patients with chronic kidney disease in a tertiary care center

Rana A. Nablawi, Adnan E. Alshaikh, Abdullah M. Alagha, Abdulrazaq A. Bahaidrah, Rayan N. Alharbi, Amar Y. Bamagaus.


Abstract
Objective: This study aimed to investigate the association between serum uric acid (UA) levels and cardiovascular disease (CVD) risk factors in patients with chronic kidney disease (CKD) among King Abdulaziz University Hospital (KAUH) patients.
Methods: This retrospective cross-sectional study collected patient information from the KAUH between January 2010 and December 2022. The study included the history of CKD and documented serum UA levels. Afterward, their demographics, comorbidities, smoking status, CKD stage, electrolytes, renal function test, lipid profile, complete blood count, medication, and health status were assessed.
Results: A study of 122 patients with CKD, mainly males (68%). CKD stage 5 showed a significant association with serum UA levels (beta = 128, 95% CI, 6.74-248, p = 0.041). Most patients were non-smokers (91.5%), with common conditions including heart failure, stroke, peripheral vascular disease, dyslipidemia, and gout. Nine patients died, with septic shock being the leading cause. No significant associations were found between serum UA levels and comorbidities. Calcium channel blockers (beta = 78.4, 95% CI, 32.1-125, p = 0.001) and diuretics (beta = 102, 95% CI, 25.8-179, p = 0.010) were significantly associated with serum UA levels, with a significant correlation observed among patients taking these medications.
Conclusion: The study found CKD stage 5 patients had a significant association with elevated serum UA levels, but no correlation was found with CVD risk. The authors recommended prospective cohort studies, larger sample sizes, and extending research to different locations in future studies.

Key words: Chronic kidney disease, cardiovascular disease, uric acid, CKD stage


 
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How to Cite this Article
Pubmed Style

Nablawi RA, Alshaikh AE, Alagha AM, Bahaidrah AA, Alharbi RN, Bamagaus AY. The association between serum uric acid levels and CVD risk factors in patients with chronic kidney disease in a tertiary care center. IJMDC. 2024; 8(9): 2412-2418. doi:10.24911/IJMDC.51-1728693782

Web Style

Nablawi RA, Alshaikh AE, Alagha AM, Bahaidrah AA, Alharbi RN, Bamagaus AY. The association between serum uric acid levels and CVD risk factors in patients with chronic kidney disease in a tertiary care center. https://www.ijmdc.com/?mno=224315 [Access: October 14, 2025]. doi:10.24911/IJMDC.51-1728693782

AMA (American Medical Association) Style

Nablawi RA, Alshaikh AE, Alagha AM, Bahaidrah AA, Alharbi RN, Bamagaus AY. The association between serum uric acid levels and CVD risk factors in patients with chronic kidney disease in a tertiary care center. IJMDC. 2024; 8(9): 2412-2418. doi:10.24911/IJMDC.51-1728693782


Vancouver/ICMJE Style

Nablawi RA, Alshaikh AE, Alagha AM, Bahaidrah AA, Alharbi RN, Bamagaus AY. The association between serum uric acid levels and CVD risk factors in patients with chronic kidney disease in a tertiary care center. IJMDC. (2024), [cited October 14, 2025]; 8(9): 2412-2418. doi:10.24911/IJMDC.51-1728693782


Harvard Style

Nablawi, R. A., Alshaikh, . A. E., Alagha, . A. M., Bahaidrah, . A. A., Alharbi, . R. N. & Bamagaus, . A. Y. (2024) The association between serum uric acid levels and CVD risk factors in patients with chronic kidney disease in a tertiary care center. IJMDC, 8 (9), 2412-2418. doi:10.24911/IJMDC.51-1728693782


Turabian Style

Nablawi, Rana A., Adnan E. Alshaikh, Abdullah M. Alagha, Abdulrazaq A. Bahaidrah, Rayan N. Alharbi, and Amar Y. Bamagaus. 2024. The association between serum uric acid levels and CVD risk factors in patients with chronic kidney disease in a tertiary care center. International Journal of Medicine in Developing Countries, 8 (9), 2412-2418. doi:10.24911/IJMDC.51-1728693782


Chicago Style

Nablawi, Rana A., Adnan E. Alshaikh, Abdullah M. Alagha, Abdulrazaq A. Bahaidrah, Rayan N. Alharbi, and Amar Y. Bamagaus. "The association between serum uric acid levels and CVD risk factors in patients with chronic kidney disease in a tertiary care center." International Journal of Medicine in Developing Countries 8 (2024), 2412-2418. doi:10.24911/IJMDC.51-1728693782


MLA (The Modern Language Association) Style

Nablawi, Rana A., Adnan E. Alshaikh, Abdullah M. Alagha, Abdulrazaq A. Bahaidrah, Rayan N. Alharbi, and Amar Y. Bamagaus. "The association between serum uric acid levels and CVD risk factors in patients with chronic kidney disease in a tertiary care center." International Journal of Medicine in Developing Countries 8.9 (2024), 2412-2418. Print. doi:10.24911/IJMDC.51-1728693782


APA (American Psychological Association) Style

Nablawi, R. A., Alshaikh, . A. E., Alagha, . A. M., Bahaidrah, . A. A., Alharbi, . R. N. & Bamagaus, . A. Y. (2024) The association between serum uric acid levels and CVD risk factors in patients with chronic kidney disease in a tertiary care center. International Journal of Medicine in Developing Countries, 8 (9), 2412-2418. doi:10.24911/IJMDC.51-1728693782




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