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Review Article
Online Published: 28 Oct 2024
 


Efficacy and safety of erenumab for preventive treatment of migraine; a systematic review

Shatha Abdulaziz Al Ammar, Rakan Abdulaziz Al Ammar, Jumana Almingash, Nouf Marzuk Al Mutairi, Mohammad Fahad Alhinti.


Abstract
Migraine is a neurological disease that is defined by recurrent attacks of disabling headaches. Its headache episodes can potentially have a disabling impact on the different functioning of the subjects. Erenumab is one of four monoclonal antibodies that have been developed as migraine preventive therapy. However, erenumab is the only, fully humanized one with the most known efficient vasodilator peptide approved for use in migraine. This study was conducted to assess erenumab efficacy and safety for the preventive treatment of migraine by reviewing the previous research reported on this subject. Previous research was obtained by searching the scientific databases using relevant terms. Eligible studies were limited to original English articles that were available in full text with an analysis of original data. Eight studies of 2,269 patients were enrolled; the population involved subjects with episodic, chronic, and resistant chronic migraine. Erenumab doses were injections of 70 and 140 mg per month. The major findings, included erenumab effectiveness, adverse effects, and efficacy associated variables. Erenumab of either available dose was effective and safe as migraine preventive treatment with few non-significant adverse effects and no gender differences regarding effectiveness and adverse effects.

Key words: Erenumab, safety, efficacy, migraine, systemic review


 
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How to Cite this Article
Pubmed Style

Ammar SAA, Ammar RAA, Almingash J, Mutairi NMA, Alhinti MF. Efficacy and safety of erenumab for preventive treatment of migraine; a systematic review. IJMDC. Online First: 28 Oct, 2024. doi:10.24911/IJMDC.51-1726604314

Web Style

Ammar SAA, Ammar RAA, Almingash J, Mutairi NMA, Alhinti MF. Efficacy and safety of erenumab for preventive treatment of migraine; a systematic review. https://www.ijmdc.com/?mno=220962 [Access: November 27, 2024]. doi:10.24911/IJMDC.51-1726604314

AMA (American Medical Association) Style

Ammar SAA, Ammar RAA, Almingash J, Mutairi NMA, Alhinti MF. Efficacy and safety of erenumab for preventive treatment of migraine; a systematic review. IJMDC. Online First: 28 Oct, 2024. doi:10.24911/IJMDC.51-1726604314


Vancouver/ICMJE Style

Ammar SAA, Ammar RAA, Almingash J, Mutairi NMA, Alhinti MF. Efficacy and safety of erenumab for preventive treatment of migraine; a systematic review. IJMDC, [cited November 27, 2024]; Online First: 28 Oct, 2024. doi:10.24911/IJMDC.51-1726604314


Harvard Style

Ammar, S. A. A., Ammar, . R. A. A., Almingash, . J., Mutairi, . N. M. A. & Alhinti, . M. F. (2024) Efficacy and safety of erenumab for preventive treatment of migraine; a systematic review. IJMDC, Online First: 28 Oct, 2024. doi:10.24911/IJMDC.51-1726604314


Turabian Style

Ammar, Shatha Abdulaziz Al, Rakan Abdulaziz Al Ammar, Jumana Almingash, Nouf Marzuk Al Mutairi, and Mohammad Fahad Alhinti. 2024. Efficacy and safety of erenumab for preventive treatment of migraine; a systematic review. International Journal of Medicine in Developing Countries, Online First: 28 Oct, 2024. doi:10.24911/IJMDC.51-1726604314


Chicago Style

Ammar, Shatha Abdulaziz Al, Rakan Abdulaziz Al Ammar, Jumana Almingash, Nouf Marzuk Al Mutairi, and Mohammad Fahad Alhinti. "Efficacy and safety of erenumab for preventive treatment of migraine; a systematic review." International Journal of Medicine in Developing Countries Online First: 28 Oct, 2024. doi:10.24911/IJMDC.51-1726604314


MLA (The Modern Language Association) Style

Ammar, Shatha Abdulaziz Al, Rakan Abdulaziz Al Ammar, Jumana Almingash, Nouf Marzuk Al Mutairi, and Mohammad Fahad Alhinti. "Efficacy and safety of erenumab for preventive treatment of migraine; a systematic review." International Journal of Medicine in Developing Countries Online First: 28 Oct, 2024. Web. 27 Nov 2024 doi:10.24911/IJMDC.51-1726604314


APA (American Psychological Association) Style

Ammar, S. A. A., Ammar, . R. A. A., Almingash, . J., Mutairi, . N. M. A. & Alhinti, . M. F. (2024) Efficacy and safety of erenumab for preventive treatment of migraine; a systematic review. International Journal of Medicine in Developing Countries, Online First: 28 Oct, 2024. doi:10.24911/IJMDC.51-1726604314




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