Epilepsy and pregnancy, mother and neonatal outcomes; systematic review

Faisal Talal Alsharif; Khalidah Hamad Alotaibi; Aroob Almuqati; Abrar Mohammed Aldossari; Ashwaq Abbas Jamjoom; Abeer Idris Bin Alshaikh; Aisha Mohammad Ahmed; Rawan Adel Alghamdi

doi:10.24911/IJMDC.51-1719557427

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Review Article
Online Published: 20 Aug 2024

IJMDC. 2024; 8(8): 2127-2135

doi: 10.24911/IJMDC.51-1719557427

Epilepsy and pregnancy, mother and neonatal outcomes; systematic review

Faisal Talal Alsharif, Khalidah Hamad Alotaibi, Aroob Almuqati, Abrar Mohammed Aldossari, Ashwaq Abbas Jamjoom, Abeer Idris Bin Alshaikh, Aisha Mohammad Ahmed, Rawan Adel Alghamdi.

Abstract
It is necessary to quantify the relationship between pregnancy outcomes and epilepsy and antiepileptic medication exposure. To look into the relationship between epilepsy and reproductive outcomes, and whether or not antiepileptic medication exposure was involved, this systematic review was conducted. This review was conducted following PRISMA guidelines. Hence, studies that discussed the newborn and maternal outcomes of mothers with epilepsy, were published between the years 2011 and 2024 and were searched using electronic databases including MEDLINE, Cochrane, AMED, and Embase, without regard to language limitations. Fourteen articles totaling 3,177,752 participants (16,647 with epilepsy and 3,161,105 without epilepsy) were included in the systematic review; twelve of the included studies discussed both maternal and neonatal outcomes, one study focused solely on neonatal outcomes, and one study solely on maternal outcomes. It was found that there is a correlation between epilepsy, antiepileptic medication exposure, and unfavorable outcomes for the mother, newborn, and infants during pregnancy.

Key words: Epilepsy, pregnancy, neonatal outcome, maternal outcome, systemic review

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Pubmed Style

Alsharif FT, Alotaibi KH, Almuqati A, Aldossari AM, Jamjoom AA, Alshaikh AIB, Ahmed AM, Alghamdi RA. Epilepsy and pregnancy, mother and neonatal outcomes; systematic review. IJMDC. 2024; 8(8): 2127-2135. doi:10.24911/IJMDC.51-1719557427

Web Style

Alsharif FT, Alotaibi KH, Almuqati A, Aldossari AM, Jamjoom AA, Alshaikh AIB, Ahmed AM, Alghamdi RA. Epilepsy and pregnancy, mother and neonatal outcomes; systematic review. https://www.ijmdc.com/?mno=207432 [Access: October 12, 2025]. doi:10.24911/IJMDC.51-1719557427

AMA (American Medical Association) Style

Alsharif FT, Alotaibi KH, Almuqati A, Aldossari AM, Jamjoom AA, Alshaikh AIB, Ahmed AM, Alghamdi RA. Epilepsy and pregnancy, mother and neonatal outcomes; systematic review. IJMDC. 2024; 8(8): 2127-2135. doi:10.24911/IJMDC.51-1719557427

Vancouver/ICMJE Style

Alsharif FT, Alotaibi KH, Almuqati A, Aldossari AM, Jamjoom AA, Alshaikh AIB, Ahmed AM, Alghamdi RA. Epilepsy and pregnancy, mother and neonatal outcomes; systematic review. IJMDC. (2024), [cited October 12, 2025]; 8(8): 2127-2135. doi:10.24911/IJMDC.51-1719557427

Harvard Style

Alsharif, F. T., Alotaibi, . K. H., Almuqati, . A., Aldossari, . A. M., Jamjoom, . A. A., Alshaikh, . A. I. B., Ahmed, . A. M. & Alghamdi, . R. A. (2024) Epilepsy and pregnancy, mother and neonatal outcomes; systematic review. IJMDC, 8 (8), 2127-2135. doi:10.24911/IJMDC.51-1719557427

Turabian Style

Alsharif, Faisal Talal, Khalidah Hamad Alotaibi, Aroob Almuqati, Abrar Mohammed Aldossari, Ashwaq Abbas Jamjoom, Abeer Idris Bin Alshaikh, Aisha Mohammad Ahmed, and Rawan Adel Alghamdi. 2024. Epilepsy and pregnancy, mother and neonatal outcomes; systematic review. International Journal of Medicine in Developing Countries, 8 (8), 2127-2135. doi:10.24911/IJMDC.51-1719557427

Chicago Style

Alsharif, Faisal Talal, Khalidah Hamad Alotaibi, Aroob Almuqati, Abrar Mohammed Aldossari, Ashwaq Abbas Jamjoom, Abeer Idris Bin Alshaikh, Aisha Mohammad Ahmed, and Rawan Adel Alghamdi. "Epilepsy and pregnancy, mother and neonatal outcomes; systematic review." International Journal of Medicine in Developing Countries 8 (2024), 2127-2135. doi:10.24911/IJMDC.51-1719557427

MLA (The Modern Language Association) Style

Alsharif, Faisal Talal, Khalidah Hamad Alotaibi, Aroob Almuqati, Abrar Mohammed Aldossari, Ashwaq Abbas Jamjoom, Abeer Idris Bin Alshaikh, Aisha Mohammad Ahmed, and Rawan Adel Alghamdi. "Epilepsy and pregnancy, mother and neonatal outcomes; systematic review." International Journal of Medicine in Developing Countries 8.8 (2024), 2127-2135. Print. doi:10.24911/IJMDC.51-1719557427

APA (American Psychological Association) Style

Alsharif, F. T., Alotaibi, . K. H., Almuqati, . A., Aldossari, . A. M., Jamjoom, . A. A., Alshaikh, . A. I. B., Ahmed, . A. M. & Alghamdi, . R. A. (2024) Epilepsy and pregnancy, mother and neonatal outcomes; systematic review. International Journal of Medicine in Developing Countries, 8 (8), 2127-2135. doi:10.24911/IJMDC.51-1719557427

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