Prevalence of food allergy and other atopy among children with eosinophilic esophagitis in single center retrospective study, Riyadh, Saudi Arabia

Yasir Albarrak; Emadia Alaki; Wadha Aldosari; Musa Alkhormi; Ahmed Alawfi; Muhannad Almajed; Husam Islam; Ghannam Alghannam; Abdulwahab Alayoubi; Amani Siddig; Meshari Aladhadh; Abdulrahman Alamri

doi:10.24911/IJMDC.51-1713018581

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Original Article
Online Published: 03 May 2024

IJMDC. 2024; 8(6): 1445-1455

doi: 10.24911/IJMDC.51-1713018581

Prevalence of food allergy and other atopy among children with eosinophilic esophagitis in single center retrospective study, Riyadh, Saudi Arabia

Yasir Albarrak, Emadia Alaki, Wadha Aldosari, Musa Alkhormi, Ahmed Alawfi, Muhannad Almajed, Husam Islam, Ghannam Alghannam, Abdulwahab Alayoubi, Amani Siddig, Meshari Aladhadh, Abdulrahman Alamri.

Abstract
Background: Eosinophilic esophagitis (EoE) is increasingly recognized as a significant public health issue in pediatric populations. The multifaceted mechanisms involving genetic, environmental, and immunological factors, particularly the role of allergens, are central to understanding EoE’s pathogenesis. This study aims to analyze the prevalence of food allergies and atopic diseases among children diagnosed with EoE, offering insights into their interrelations and informing improved management strategies.
Methods: This retrospective study analyzed 47 pediatric patients diagnosed with EoE at the Allergy and Gastroenterology Clinic, Children’s Hospital, King Saud Medical City, Riyadh, from February 2012 to December 2018. Patients were selected based on documented food allergies, anaphylactic reactions, comorbid atopic conditions, positive radioallergosorbent test (RAST) results, and elevated eosinophilia. Data collection involved medical records and detailed family questionnaires. Immunological assays and endoscopic biopsies were used for diagnosis, with EoE defined as more than 15 eosinophils/high power field.
Results: The study population predominantly comprised Saudi males, with a mean age of 8.36 years. A significant portion had consanguineous parents. Notable findings include a high prevalence of asthma (46.8%), allergic rhinitis (23.4%), and eczema (25.5%). The most common food allergens identified were peanuts, nuts, and seafood. Asthma severity varied, with ventolin and fluticasone being the most prescribed medications. Laboratory investigations showed elevated white blood cell, absolute neutrophil count, lymph, eosinophil sedimentation rat (ESO), eosinophil percentage, and immunoglobulin E (IgE) levels. RAST indicated specific allergen sensitivities in 34.0% of patients.
Conclusion: This study provides essential insights into the demographic, clinical, and therapeutic aspects of pediatric EoE, emphasizing the importance of a comprehensive, personalized approach to management.

Key words: Eosinophilic esophagitis, pediatric allergy, food allergies, atopic diseases, Saudi Arabia

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Pubmed Style

Albarrak Y, Alaki E, Aldosari W, Alkhormi M, Alawfi A, Almajed M, Islam H, Alghannam G, Alayoubi A, Siddig A, Aladhadh M, Alamri A. Prevalence of food allergy and other atopy among children with eosinophilic esophagitis in single center retrospective study, Riyadh, Saudi Arabia. IJMDC. 2024; 8(6): 1445-1455. doi:10.24911/IJMDC.51-1713018581

Web Style

Albarrak Y, Alaki E, Aldosari W, Alkhormi M, Alawfi A, Almajed M, Islam H, Alghannam G, Alayoubi A, Siddig A, Aladhadh M, Alamri A. Prevalence of food allergy and other atopy among children with eosinophilic esophagitis in single center retrospective study, Riyadh, Saudi Arabia. https://www.ijmdc.com/?mno=197570 [Access: January 23, 2025]. doi:10.24911/IJMDC.51-1713018581

AMA (American Medical Association) Style

Albarrak Y, Alaki E, Aldosari W, Alkhormi M, Alawfi A, Almajed M, Islam H, Alghannam G, Alayoubi A, Siddig A, Aladhadh M, Alamri A. Prevalence of food allergy and other atopy among children with eosinophilic esophagitis in single center retrospective study, Riyadh, Saudi Arabia. IJMDC. 2024; 8(6): 1445-1455. doi:10.24911/IJMDC.51-1713018581

Vancouver/ICMJE Style

Albarrak Y, Alaki E, Aldosari W, Alkhormi M, Alawfi A, Almajed M, Islam H, Alghannam G, Alayoubi A, Siddig A, Aladhadh M, Alamri A. Prevalence of food allergy and other atopy among children with eosinophilic esophagitis in single center retrospective study, Riyadh, Saudi Arabia. IJMDC. (2024), [cited January 23, 2025]; 8(6): 1445-1455. doi:10.24911/IJMDC.51-1713018581

Harvard Style

Albarrak, Y., Alaki, . E., Aldosari, . W., Alkhormi, . M., Alawfi, . A., Almajed, . M., Islam, . H., Alghannam, . G., Alayoubi, . A., Siddig, . A., Aladhadh, . M. & Alamri, . A. (2024) Prevalence of food allergy and other atopy among children with eosinophilic esophagitis in single center retrospective study, Riyadh, Saudi Arabia. IJMDC, 8 (6), 1445-1455. doi:10.24911/IJMDC.51-1713018581

Turabian Style

Albarrak, Yasir, Emadia Alaki, Wadha Aldosari, Musa Alkhormi, Ahmed Alawfi, Muhannad Almajed, Husam Islam, Ghannam Alghannam, Abdulwahab Alayoubi, Amani Siddig, Meshari Aladhadh, and Abdulrahman Alamri. 2024. Prevalence of food allergy and other atopy among children with eosinophilic esophagitis in single center retrospective study, Riyadh, Saudi Arabia. International Journal of Medicine in Developing Countries, 8 (6), 1445-1455. doi:10.24911/IJMDC.51-1713018581

Chicago Style

Albarrak, Yasir, Emadia Alaki, Wadha Aldosari, Musa Alkhormi, Ahmed Alawfi, Muhannad Almajed, Husam Islam, Ghannam Alghannam, Abdulwahab Alayoubi, Amani Siddig, Meshari Aladhadh, and Abdulrahman Alamri. "Prevalence of food allergy and other atopy among children with eosinophilic esophagitis in single center retrospective study, Riyadh, Saudi Arabia." International Journal of Medicine in Developing Countries 8 (2024), 1445-1455. doi:10.24911/IJMDC.51-1713018581

MLA (The Modern Language Association) Style

Albarrak, Yasir, Emadia Alaki, Wadha Aldosari, Musa Alkhormi, Ahmed Alawfi, Muhannad Almajed, Husam Islam, Ghannam Alghannam, Abdulwahab Alayoubi, Amani Siddig, Meshari Aladhadh, and Abdulrahman Alamri. "Prevalence of food allergy and other atopy among children with eosinophilic esophagitis in single center retrospective study, Riyadh, Saudi Arabia." International Journal of Medicine in Developing Countries 8.6 (2024), 1445-1455. Print. doi:10.24911/IJMDC.51-1713018581

APA (American Psychological Association) Style

Albarrak, Y., Alaki, . E., Aldosari, . W., Alkhormi, . M., Alawfi, . A., Almajed, . M., Islam, . H., Alghannam, . G., Alayoubi, . A., Siddig, . A., Aladhadh, . M. & Alamri, . A. (2024) Prevalence of food allergy and other atopy among children with eosinophilic esophagitis in single center retrospective study, Riyadh, Saudi Arabia. International Journal of Medicine in Developing Countries, 8 (6), 1445-1455. doi:10.24911/IJMDC.51-1713018581

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