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Review Article
Online Published: 20 Dec 2023
 


Prevalence, Risk Factors, and Management of Cluster headache; A systematic Review

Rofayda Mansour Ahmad Mohamad, Nouf Salem Albalawi, Rahaf Masoud Albalawi, Nawaf Farhan Alghamdi, Naif Ibrahim Alzahrani, Hanan Ali Atafi, Hotoon Kamel Alghaythee, Alyaa Mohammed Izaldin Haider, Zainab Esameldeen Abujamal, Alhanouf Radhyan Alruwili, Zahraa Hussain Aljeshi, Majed Mohammad Qaysi, Hosam Hadi Awaji.


Abstract
Cluster headache (CH) is intricately linked to diverse risk factors, spanning hereditary, environmental, and lifestyle elements. This systematic study, guided by PRISMA guidelines, delves into the prevalence, risk factors, and management of CH. Examining English-language articles from 2010 to 2023 via PubMed/Medline, Scopus, and Embase, our findings reveal a significant association between cluster headaches and factors including family history, smoking, alcohol consumption, male predominance, and head trauma. Notably, a reevaluation of sex discrimination in familial cases is warranted, given the observed female predominance in familial history and CH association studies. Reviewing 739 studies, 7 met inclusion criteria, predominantly utilizing surveys and national database analyses (n=7). Improving our grasp of diagnosis and treatment holds promise for future evaluation and management. Our conclusion underscores global variability in CH prevalence, urging more rigorous population-based surveys. The substantial and persistent burdens associated with CH, from suicidality to economic stress, underscore the need for comprehensive research and intervention. CH transcends the label of a mere "trigeminal autonomic headache," showcasing a diverse spectrum of attack and bout characteristics across countries and ethnicities. Despite the global efficacy of current diagnostic criteria, CH emerges as a dynamic illness, demonstrating progression or regression over time. This underscores the necessity for further research in comprehending its trajectory.

Key words: Cluster headache, Trigeminal autonomic cephalalgia, Headache, Genetics, Family history, Heritability, Heredity, Inheritance


 
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How to Cite this Article
Pubmed Style

Mohamad RMA, Albalawi NS, Albalawi RM, Alghamdi NF, Alzahrani NI, Atafi HA, Alghaythee HK, Haider AMI, Abujamal ZE, Alruwili AR, Aljeshi ZH, Qaysi MM, Awaji HH. Prevalence, Risk Factors, and Management of Cluster headache; A systematic Review. IJMDC. 2024; 8(1): 415-423. doi:10.24911/IJMDC.51-1700669192

Web Style

Mohamad RMA, Albalawi NS, Albalawi RM, Alghamdi NF, Alzahrani NI, Atafi HA, Alghaythee HK, Haider AMI, Abujamal ZE, Alruwili AR, Aljeshi ZH, Qaysi MM, Awaji HH. Prevalence, Risk Factors, and Management of Cluster headache; A systematic Review. https://www.ijmdc.com/?mno=178461 [Access: June 22, 2026]. doi:10.24911/IJMDC.51-1700669192

AMA (American Medical Association) Style

Mohamad RMA, Albalawi NS, Albalawi RM, Alghamdi NF, Alzahrani NI, Atafi HA, Alghaythee HK, Haider AMI, Abujamal ZE, Alruwili AR, Aljeshi ZH, Qaysi MM, Awaji HH. Prevalence, Risk Factors, and Management of Cluster headache; A systematic Review. IJMDC. 2024; 8(1): 415-423. doi:10.24911/IJMDC.51-1700669192


Vancouver/ICMJE Style

Mohamad RMA, Albalawi NS, Albalawi RM, Alghamdi NF, Alzahrani NI, Atafi HA, Alghaythee HK, Haider AMI, Abujamal ZE, Alruwili AR, Aljeshi ZH, Qaysi MM, Awaji HH. Prevalence, Risk Factors, and Management of Cluster headache; A systematic Review. IJMDC. (2024), [cited June 22, 2026]; 8(1): 415-423. doi:10.24911/IJMDC.51-1700669192


Harvard Style

Mohamad, R. M. A., Albalawi, . N. S., Albalawi, . R. M., Alghamdi, . N. F., Alzahrani, . N. I., Atafi, . H. A., Alghaythee, . H. K., Haider, . A. M. I., Abujamal, . Z. E., Alruwili, . A. R., Aljeshi, . Z. H., Qaysi, . M. M. & Awaji, . H. H. (2024) Prevalence, Risk Factors, and Management of Cluster headache; A systematic Review. IJMDC, 8 (1), 415-423. doi:10.24911/IJMDC.51-1700669192


Turabian Style

Mohamad, Rofayda Mansour Ahmad, Nouf Salem Albalawi, Rahaf Masoud Albalawi, Nawaf Farhan Alghamdi, Naif Ibrahim Alzahrani, Hanan Ali Atafi, Hotoon Kamel Alghaythee, Alyaa Mohammed Izaldin Haider, Zainab Esameldeen Abujamal, Alhanouf Radhyan Alruwili, Zahraa Hussain Aljeshi, Majed Mohammad Qaysi, and Hosam Hadi Awaji. 2024. Prevalence, Risk Factors, and Management of Cluster headache; A systematic Review. International Journal of Medicine in Developing Countries, 8 (1), 415-423. doi:10.24911/IJMDC.51-1700669192


Chicago Style

Mohamad, Rofayda Mansour Ahmad, Nouf Salem Albalawi, Rahaf Masoud Albalawi, Nawaf Farhan Alghamdi, Naif Ibrahim Alzahrani, Hanan Ali Atafi, Hotoon Kamel Alghaythee, Alyaa Mohammed Izaldin Haider, Zainab Esameldeen Abujamal, Alhanouf Radhyan Alruwili, Zahraa Hussain Aljeshi, Majed Mohammad Qaysi, and Hosam Hadi Awaji. "Prevalence, Risk Factors, and Management of Cluster headache; A systematic Review." International Journal of Medicine in Developing Countries 8 (2024), 415-423. doi:10.24911/IJMDC.51-1700669192


MLA (The Modern Language Association) Style

Mohamad, Rofayda Mansour Ahmad, Nouf Salem Albalawi, Rahaf Masoud Albalawi, Nawaf Farhan Alghamdi, Naif Ibrahim Alzahrani, Hanan Ali Atafi, Hotoon Kamel Alghaythee, Alyaa Mohammed Izaldin Haider, Zainab Esameldeen Abujamal, Alhanouf Radhyan Alruwili, Zahraa Hussain Aljeshi, Majed Mohammad Qaysi, and Hosam Hadi Awaji. "Prevalence, Risk Factors, and Management of Cluster headache; A systematic Review." International Journal of Medicine in Developing Countries 8.1 (2024), 415-423. Print. doi:10.24911/IJMDC.51-1700669192


APA (American Psychological Association) Style

Mohamad, R. M. A., Albalawi, . N. S., Albalawi, . R. M., Alghamdi, . N. F., Alzahrani, . N. I., Atafi, . H. A., Alghaythee, . H. K., Haider, . A. M. I., Abujamal, . Z. E., Alruwili, . A. R., Aljeshi, . Z. H., Qaysi, . M. M. & Awaji, . H. H. (2024) Prevalence, Risk Factors, and Management of Cluster headache; A systematic Review. International Journal of Medicine in Developing Countries, 8 (1), 415-423. doi:10.24911/IJMDC.51-1700669192




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