Review Article
IJMDC. 2023; 7(6): 921-929
Prevalence and diagnosis of allergic bronchopulmonary aspergillosis: a systematic review
Authors: Emad Abdulrahman Nasser Hadal, Mohammad Helail Almutairi, Abdullah Talal Almutairi, Turki Rashieed Alrumayh, Deafalah Abdulrahman N. Hadal, Naif Essam T. Alotishan.
ABSTRACT
Background: Allergic bronchopulmonary aspergillosis (ABPA), a chronic fungal allergic lung condition, is a common side effect of asthma or cystic fibrosis (CF). The majority of patients affected by Aspergillus species, notably Aspergillus fumigatus, experience allergic respiratory symptoms. Aspergillus-induced lung illness and maladaptive immune responses range from developing essential fungal asthma to severe asthma with fungal sensitization to ABPA. The estimated ABPA prevalence in CF patients varied from 3% to 25% in adults and 8% to 10% in children, for an overall prevalence of 8.9%. Aim: To evaluate the current literature on the prevalence and diagnosis of allergic ABPA. Methods: Studies related to our subject were explored using PubMed and Google Scholar databases. The keywords included were “Respiratory allergy, bronchopulmonary aspergillus, allergic bronchopulmonary aspergillosis, prevalence, and diagnosis” and were used in various combinations. The inclusion criteria were original studies that reported ABPA and full articles. Results: A total of 200 articles were obtained, but only 9 articles were eligible for the inclusion criteria. The detailed studies were conducted on 929 participants, 8 of them were cross-sectional studies, and only 1 was a prospective longitudinal study. Conclusion: Our study showed that ABPA has a moderate prevalence among patients with asthma and CF. No risk factors were found for ABPA other than the appearance of brownish sputum in children with ABPA. The clinical manifestations of ABPA were a late start, decreased blood immunoglobulin E levels, and frequent recurrences/ flares. Several diagnostic biomarkers were shown to be effective in the diagnosis of ABPA, including basophil CD203c upregulation and Thymus and activation-regulated chemokine.
Keywords:
Respiratory allergy, bronchopulmonary aspergillus, allergic bronchopulmonary aspergillosis, prevalence, and diagnosis.
Authors
Emad Abdulrahman Nasser Hadal
Resident physician, Security Forces Hospital, Riyadh, Saudi Arabia
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Mohammad Helail Almutairi
Resident Service under Family Medicine in East Clinic Family Medicine, Security Forces Hospital, Riyadh, Saudi Arabia
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Abdullah Talal Almutairi
Resident Physician at Emergency Department, Alquwayiyah Hospital, Alquwayiyah, Saudi Arabia
PubMed articlesGoogle scholar articles
Turki Rashieed Alrumayh
Resident Physician at Emergency Department, Alquwayiyah Hospital, Alquwayiyah, Saudi Arabia
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Deafalah Abdulrahman N Hadal
Internal Medicine Consultant, Prince Sultan Military Medical City, Riyadh, Saudi Arabia
PubMed articlesGoogle scholar articles
Naif Essam T Alotishan
Medical Physician, KFMMC, Dammam, Saudi Arabia.
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Correspondence to:
. Emad Abdulrahman Nasser Hadal, Resident physician, Security Forces Hospital, Riyadh, Saudi Arabia; Eh.glcn@gmail.com
Publication history
Received 30 Dec 2022
Accepted 14 Jan 2023
Published online 15 Jan 2023
Published in print 13 Mar 2023
How to cite this article?
Export to EndNote Export to refManPubmed Style
Hadal EAN, Almutairi MH, Almutairi AT, Alrumayh TR, Hadal DAN, Alotishan NET. Prevalence and diagnosis of allergic bronchopulmonary aspergillosis: a systematic review. IJMDC. 2023; 7(6): 921-929. doi:10.24911/IJMDC.51-1672401472
Web Style
Hadal EAN, Almutairi MH, Almutairi AT, Alrumayh TR, Hadal DAN, Alotishan NET. Prevalence and diagnosis of allergic bronchopulmonary aspergillosis: a systematic review. https://www.ijmdc.com/?mno=135241 [Access: May 28, 2023]. doi:10.24911/IJMDC.51-1672401472
AMA (American Medical Association) Style
Hadal EAN, Almutairi MH, Almutairi AT, Alrumayh TR, Hadal DAN, Alotishan NET. Prevalence and diagnosis of allergic bronchopulmonary aspergillosis: a systematic review. IJMDC. 2023; 7(6): 921-929. doi:10.24911/IJMDC.51-1672401472
Vancouver/ICMJE Style
Hadal EAN, Almutairi MH, Almutairi AT, Alrumayh TR, Hadal DAN, Alotishan NET. Prevalence and diagnosis of allergic bronchopulmonary aspergillosis: a systematic review. IJMDC. (2023), [cited May 28, 2023]; 7(6): 921-929. doi:10.24911/IJMDC.51-1672401472
Harvard Style
Hadal, E. A. N., Almutairi, . M. H., Almutairi, . A. T., Alrumayh, . T. R., Hadal, . D. A. N. & Alotishan, . N. E. T. (2023) Prevalence and diagnosis of allergic bronchopulmonary aspergillosis: a systematic review. IJMDC, 7 (6), 921-929. doi:10.24911/IJMDC.51-1672401472
Turabian Style
Hadal, Emad Abdulrahman Nasser, Mohammad Helail Almutairi, Abdullah Talal Almutairi, Turki Rashieed Alrumayh, Deafalah Abdulrahman N. Hadal, and Naif Essam T. Alotishan. 2023. Prevalence and diagnosis of allergic bronchopulmonary aspergillosis: a systematic review. International Journal of Medicine in Developing Countries, 7 (6), 921-929. doi:10.24911/IJMDC.51-1672401472
Chicago Style
Hadal, Emad Abdulrahman Nasser, Mohammad Helail Almutairi, Abdullah Talal Almutairi, Turki Rashieed Alrumayh, Deafalah Abdulrahman N. Hadal, and Naif Essam T. Alotishan. "Prevalence and diagnosis of allergic bronchopulmonary aspergillosis: a systematic review." International Journal of Medicine in Developing Countries 7 (2023), 921-929. doi:10.24911/IJMDC.51-1672401472
MLA (The Modern Language Association) Style
Hadal, Emad Abdulrahman Nasser, Mohammad Helail Almutairi, Abdullah Talal Almutairi, Turki Rashieed Alrumayh, Deafalah Abdulrahman N. Hadal, and Naif Essam T. Alotishan. "Prevalence and diagnosis of allergic bronchopulmonary aspergillosis: a systematic review." International Journal of Medicine in Developing Countries 7.6 (2023), 921-929. Print. doi:10.24911/IJMDC.51-1672401472
APA (American Psychological Association) Style
Hadal, E. A. N., Almutairi, . M. H., Almutairi, . A. T., Alrumayh, . T. R., Hadal, . D. A. N. & Alotishan, . N. E. T. (2023) Prevalence and diagnosis of allergic bronchopulmonary aspergillosis: a systematic review. International Journal of Medicine in Developing Countries, 7 (6), 921-929. doi:10.24911/IJMDC.51-1672401472
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