Total bilirubin trend as a predictor of choledocholithiasis in patients with gallstones disease

Nadia Aljomah; Thamer Nouh; Abdullah Albdah; Ahmed Alburaikan; Shara M. Alsubaie; Ahad Alhassan Alsaud; Mishary Shalhoub; Bishr Murad; Khalil Alawi; Norah Alsubaie

doi:10.24911/IJMDC.51-1668847066

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Original Article

Online Publishing Date:
25 / 12 / 2022

IJMDC. 2023; 7(2): 249-254

doi: 10.24911/IJMDC.51-1668847066

Total bilirubin trend as a predictor of choledocholithiasis in patients with gallstones disease

Nadia Aljomah, Thamer Nouh, Abdullah Albdah, Ahmed Alburaikan, Shara M. Alsubaie, Ahad Alhassan Alsaud, Mishary Shalhoub, Bishr Murad, Khalil Alawi, Norah Alsubaie.

Abstract
Background: Many diagnostic parameters represent the presence of a common bile duct (CBD) stone, either pre-intra or post-operatively. It varies from lab work to imaging modalities. In this study, we aim to look for the trend of total bilirubin level and its relation to the presence of CBD stones in patients with gallstone disease.
Methods: A retrospective study was conducted at King Saud University Medical City, involving 280 patients admitted through the emergency department; with a picture of gallstones disease associated with high readings of total and direct bilirubin; from 2017 to 2019, the relation of high levels of bilirubin liver enzymes, gamma-glutamyl transferase (GGT), alkaline phosphatase to the presence of CBD stone was established.
Results: Out of 280 patients, 96 were male, and 184 were female. Total bilirubin was high in 28 (10%) patients overall, with a higher proportion of patients reporting high total bilirubin among patients with detected CBD stones. First and third total bilirubin measurements recorded a median (IQR) of 19.64 (8.65-39.85), and 15.19 (8.10-29.81), respectively, with a 50% reduction noted among 63 (22.5%) patients of all participants. Moreover, normalization of total bilirubin was reported among 134 (47.9%) patients overall, with normalization reported in more patients with no CBD stones. GGT was found to be the only laboratory test significantly related to choledocholithiasis.
Conclusion: High levels of bilirubin and alkaline phosphatase were found as predictors of choledocholithiasis, while other laboratory markers were not. Further imagining studies are warranted to diagnose the presence of CBD stones.

Key words: Total bilirubin, CBD stones, choledocholithiasis, predictors.

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Pubmed Style

Aljomah N, Nouh T, Albdah A, Alburaikan A, Alsubaie SM, Alsaud AA, Shalhoub M, Murad B, Alawi K, Alsubaie N. Total bilirubin trend as a predictor of choledocholithiasis in patients with gallstones disease. IJMDC. 2023; 7(2): 249-254. doi:10.24911/IJMDC.51-1668847066

Web Style

Aljomah N, Nouh T, Albdah A, Alburaikan A, Alsubaie SM, Alsaud AA, Shalhoub M, Murad B, Alawi K, Alsubaie N. Total bilirubin trend as a predictor of choledocholithiasis in patients with gallstones disease. https://www.ijmdc.com/?mno=131072 [Access: March 26, 2024]. doi:10.24911/IJMDC.51-1668847066

AMA (American Medical Association) Style

Aljomah N, Nouh T, Albdah A, Alburaikan A, Alsubaie SM, Alsaud AA, Shalhoub M, Murad B, Alawi K, Alsubaie N. Total bilirubin trend as a predictor of choledocholithiasis in patients with gallstones disease. IJMDC. 2023; 7(2): 249-254. doi:10.24911/IJMDC.51-1668847066

Vancouver/ICMJE Style

Aljomah N, Nouh T, Albdah A, Alburaikan A, Alsubaie SM, Alsaud AA, Shalhoub M, Murad B, Alawi K, Alsubaie N. Total bilirubin trend as a predictor of choledocholithiasis in patients with gallstones disease. IJMDC. (2023), [cited March 26, 2024]; 7(2): 249-254. doi:10.24911/IJMDC.51-1668847066

Harvard Style

Aljomah, N., Nouh, . T., Albdah, . A., Alburaikan, . A., Alsubaie, . S. M., Alsaud, . A. A., Shalhoub, . M., Murad, . B., Alawi, . K. & Alsubaie, . N. (2023) Total bilirubin trend as a predictor of choledocholithiasis in patients with gallstones disease. IJMDC, 7 (2), 249-254. doi:10.24911/IJMDC.51-1668847066

Turabian Style

Aljomah, Nadia, Thamer Nouh, Abdullah Albdah, Ahmed Alburaikan, Shara M. Alsubaie, Ahad Alhassan Alsaud, Mishary Shalhoub, Bishr Murad, Khalil Alawi, and Norah Alsubaie. 2023. Total bilirubin trend as a predictor of choledocholithiasis in patients with gallstones disease. International Journal of Medicine in Developing Countries, 7 (2), 249-254. doi:10.24911/IJMDC.51-1668847066

Chicago Style

Aljomah, Nadia, Thamer Nouh, Abdullah Albdah, Ahmed Alburaikan, Shara M. Alsubaie, Ahad Alhassan Alsaud, Mishary Shalhoub, Bishr Murad, Khalil Alawi, and Norah Alsubaie. "Total bilirubin trend as a predictor of choledocholithiasis in patients with gallstones disease." International Journal of Medicine in Developing Countries 7 (2023), 249-254. doi:10.24911/IJMDC.51-1668847066

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Aljomah, N., Nouh, . T., Albdah, . A., Alburaikan, . A., Alsubaie, . S. M., Alsaud, . A. A., Shalhoub, . M., Murad, . B., Alawi, . K. & Alsubaie, . N. (2023) Total bilirubin trend as a predictor of choledocholithiasis in patients with gallstones disease. International Journal of Medicine in Developing Countries, 7 (2), 249-254. doi:10.24911/IJMDC.51-1668847066

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