Alternative levothyroxine administrating time: a systematic review

Ibarhim Mahmoud Ajwah; Badr Mohammed Alsharif; Abdullah Noman Alatawi; Yousef Musallam Albalawi; Othman Musad Albalawi; Assem Hammad Altemani; Kholoud Abdullah Aljohani; Shelian Juweed Alnomsi; Kholud Eid Albalawi; Elhassan Asia A; Marwa Mamoun Suliman; Hyder Osman Marghani

doi:10.24911/IJMDC.51-1588450423

2024, Vol: 8, Issue: 4

8 / 4Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

« Previous Article

Review Article

Online Publishing Date:
27 / 05 / 2020

IJMDC. 2020; 4(6): 1022-1027

doi: 10.24911/IJMDC.51-1588450423

Alternative levothyroxine administrating time: a systematic review

Ibarhim Mahmoud Ajwah, Badr Mohammed Alsharif, Abdullah Noman Alatawi, Yousef Musallam Albalawi, Othman Musad Albalawi, Assem Hammad Altemani, Kholoud Abdullah Aljohani, Shelian Juweed Alnomsi, Kholud Eid Albalawi, Elhassan Asia A, Marwa Mamoun Suliman, Hyder Osman Marghani.

Abstract
Studies justify prescribing levothyroxine (LT4) as the first-line treatment for patients with hypothyroidism. However, the strict administration requirements, since LT4 optimally absorbed during fasting state which mandates delaying of any food for at least 30 minutes. Consequently, the compliance with these instructions may be problematic for the patient's adherence. Therefore, we aimed to systematically assess the effects of bedtime LT4 administration on the degree of hypothyroidism clinical parameters. Several databases were systematically searched for relevant papers on alternative Levothyroxine administrating time. The papers published in the English language from the first available article up to March 2020 were approached. The terms hypothyroidism, LT4, and bed-time were used. Out of 316 papers retrieved, only seven fulfilled the inclusion and exclusion criteria. In the current review, seven full texts fulfilled the inclusion and exclusion criteria, of the two, showed a reduction in thyroid stimulating hormone (TSH) when thyroxine was administered at bedtime. Three studies showed that the bed-time administration is as effective as standard morning time administration. The last two studies examine the possibility of LT4 co-administration with meals and both show statistically significant higher TSH seen with non-fasting regimens. The review concluded that the medication adherence will be affected by the patient's preference. Therefore, if Levothyroxine administrating (30-60 minutes) before breakfast is not convenient, alternative regiment, such as bed-time or co-administration with the meal, may also be an option.

Key words: Bedtime, hypothyroidism, levothyroxine, review.

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Ibarhim Mahmoud Ajwah Articles by Badr Mohammed Alsharif Articles by Abdullah Noman Alatawi Articles by Yousef Musallam Albalawi Articles by Othman Musad Albalawi Articles by Assem Hammad Altemani Articles by Kholoud Abdullah Aljohani Articles by Shelian Juweed Alnomsi Articles by Kholud Eid Albalawi Articles by Elhassan Asia A Articles by Marwa Mamoun Suliman Articles by Hyder Osman Marghani
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Ajwah IM, Alsharif BM, Alatawi AN, Albalawi YM, Albalawi OM, Altemani AH, Aljohani KA, Alnomsi SJ, Albalawi KE, A EA, Suliman MM, Marghani HO. Alternative levothyroxine administrating time: a systematic review. IJMDC. 2020; 4(6): 1022-1027. doi:10.24911/IJMDC.51-1588450423

Web Style

Ajwah IM, Alsharif BM, Alatawi AN, Albalawi YM, Albalawi OM, Altemani AH, Aljohani KA, Alnomsi SJ, Albalawi KE, A EA, Suliman MM, Marghani HO. Alternative levothyroxine administrating time: a systematic review. https://www.ijmdc.com/?mno=103970 [Access: March 27, 2024]. doi:10.24911/IJMDC.51-1588450423

AMA (American Medical Association) Style

Ajwah IM, Alsharif BM, Alatawi AN, Albalawi YM, Albalawi OM, Altemani AH, Aljohani KA, Alnomsi SJ, Albalawi KE, A EA, Suliman MM, Marghani HO. Alternative levothyroxine administrating time: a systematic review. IJMDC. 2020; 4(6): 1022-1027. doi:10.24911/IJMDC.51-1588450423

Vancouver/ICMJE Style

Ajwah IM, Alsharif BM, Alatawi AN, Albalawi YM, Albalawi OM, Altemani AH, Aljohani KA, Alnomsi SJ, Albalawi KE, A EA, Suliman MM, Marghani HO. Alternative levothyroxine administrating time: a systematic review. IJMDC. (2020), [cited March 27, 2024]; 4(6): 1022-1027. doi:10.24911/IJMDC.51-1588450423

Harvard Style

Ajwah, I. M., Alsharif, . B. M., Alatawi, . A. N., Albalawi, . Y. M., Albalawi, . O. M., Altemani, . A. H., Aljohani, . K. A., Alnomsi, . S. J., Albalawi, . K. E., A, . E. A., Suliman, . M. M. & Marghani, . H. O. (2020) Alternative levothyroxine administrating time: a systematic review. IJMDC, 4 (6), 1022-1027. doi:10.24911/IJMDC.51-1588450423

Turabian Style

Ajwah, Ibarhim Mahmoud, Badr Mohammed Alsharif, Abdullah Noman Alatawi, Yousef Musallam Albalawi, Othman Musad Albalawi, Assem Hammad Altemani, Kholoud Abdullah Aljohani, Shelian Juweed Alnomsi, Kholud Eid Albalawi, Elhassan Asia A, Marwa Mamoun Suliman, and Hyder Osman Marghani. 2020. Alternative levothyroxine administrating time: a systematic review. International Journal of Medicine in Developing Countries, 4 (6), 1022-1027. doi:10.24911/IJMDC.51-1588450423

Chicago Style

Ajwah, Ibarhim Mahmoud, Badr Mohammed Alsharif, Abdullah Noman Alatawi, Yousef Musallam Albalawi, Othman Musad Albalawi, Assem Hammad Altemani, Kholoud Abdullah Aljohani, Shelian Juweed Alnomsi, Kholud Eid Albalawi, Elhassan Asia A, Marwa Mamoun Suliman, and Hyder Osman Marghani. "Alternative levothyroxine administrating time: a systematic review." International Journal of Medicine in Developing Countries 4 (2020), 1022-1027. doi:10.24911/IJMDC.51-1588450423

MLA (The Modern Language Association) Style

Ajwah, Ibarhim Mahmoud, Badr Mohammed Alsharif, Abdullah Noman Alatawi, Yousef Musallam Albalawi, Othman Musad Albalawi, Assem Hammad Altemani, Kholoud Abdullah Aljohani, Shelian Juweed Alnomsi, Kholud Eid Albalawi, Elhassan Asia A, Marwa Mamoun Suliman, and Hyder Osman Marghani. "Alternative levothyroxine administrating time: a systematic review." International Journal of Medicine in Developing Countries 4.6 (2020), 1022-1027. Print. doi:10.24911/IJMDC.51-1588450423

APA (American Psychological Association) Style

Ajwah, I. M., Alsharif, . B. M., Alatawi, . A. N., Albalawi, . Y. M., Albalawi, . O. M., Altemani, . A. H., Aljohani, . K. A., Alnomsi, . S. J., Albalawi, . K. E., A, . E. A., Suliman, . M. M. & Marghani, . H. O. (2020) Alternative levothyroxine administrating time: a systematic review. International Journal of Medicine in Developing Countries, 4 (6), 1022-1027. doi:10.24911/IJMDC.51-1588450423

Most Viewed Articles

Most Accessed Articles

Marginal adaptation of fixed prosthodontics
Shahad Mohammed Halawani, Sahar Amer Al-Harbi
IJMDC. 2017; 1(2): 78-84
» Abstract » doi: 10.24911/IJMDC.1.2.7

Parasites in central nervous system
Amal Ahmed Mohamed, Asmaa Mohamed Mansour
IJMDC. 2017; 1(2): 72-77
» Abstract » doi: 10.24911/IJMDC.1.2.6

Non-diabetic retinopathy: a case report
Hassan F. Alkwikbi, Nabil Mamon Abdelfattah, Haithem Mamon Abdelfattah
IJMDC. 2017; 1(1): 33-37
» Abstract » doi: 10.24911/IJMDC.1.1.6

Vitamin D deficiency among high school female students in Riyadh
Sahar Mohsen Aldhafeeri, Fatemah Ibraheem Alrawaji, Abrar Mubarak Algharbi, Alanoud Abdullah Alhessan, Ayat Sami Qabaja, Ghaleah Abdulaziz Alnassar, Ghaliah Ofayn Alsulami, Mashael Belal Alrubaian, Norah Abdulaziz Alhatim, Salehah Salih Alotaibi, Zahra Ali Alkhamees
IJMDC. 2017; 1(1): 18-23
» Abstract » doi: 10.24911/IJMDC.1.1.4

Prognosis of chronic complications of diabetes mellitus (DM) after multiple events of diabetic ketoacidosis (DKA)
Baraa Faiez Rajab, Anwar Essa Alamrim, Ali Essa Alamri
IJMDC. 2019; 3(5): 474-479
» Abstract » doi: 10.24911/IJMDC.51-1546551993

Most Downloaded

Top Downloaded Articles

Anti-IL-17 markedly inhibited the in vitro granuloma induced by Schistosoma mansoni soluble egg antigen.
Asmaa Ezz, Irene S. Gmail, Fatma Elzahraa H. Salem, Rabab Salama, Soad Nady
IJMDC. 2018; 2(January 2018): 38-46
» Abstract » doi: 10.24911/IJMDC.2.1.7

Antibiotic Resistance Crisis
Nuha Saad Mobarki, Buthaina Abdullah Almerabi, Ahmad Hattan Hattan
IJMDC. 2019; 3(6): 561-564
» Abstract » doi: 10.24911/IJMDC.51-1549060699

The knowledge of mothers about children malnutrition and associated factors
Anas Abdulrahman Aljohani, Mujahid Abdulrahman Aljohani
IJMDC. 2020; 4(1): 7-11
» Abstract » doi: 10.24911/IJMDC.51-1541620358

Knowledge and attitude of caregivers of cerebral palsy children in Riyadh city
Abdulaziz Alruwaished, Baleegh Ali, Lubna Abdullah Alhowaimil , Abaraa adullah Alhowaimil, Najd Abdullah Alhowaimil, Aminah Alessa
IJMDC. 2020; 4(1): 12-17
» Abstract » doi: 10.24911/IJMDC.51-1547833051

Most Cited Articles

Most Cited Articles

Antibiotic Resistance Crisis
Nuha Saad Mobarki, Buthaina Abdullah Almerabi, Ahmad Hattan Hattan
IJMDC. 2019; 3(6): 561-564
» Abstract » doi: 10.24911/IJMDC.51-1549060699
Cited : 34 times [Click to see citing articles]

Prevalence of depression, anxiety and stress among diabetes mellitus patients in Arar, Northern Saudi Arabia
AMohammed Elamin Mukrim, Nujud Muteb D. Alshammari, Wurud Muteb D. Alshammari, Maali Subhi T. Alshammari, Yousef Nasif R. Alshammari, Abdulaziz Sael M. Alshammari, Maisa Hamad F. Alanazi, Abdulelah Abdulrhman F. Alzammam, Muharib Mana M. Alshammari, Slwa Khaled Abu Asyah, Aseel Jamal Alzuhayri, Mushref Saeid Alshammari
IJMDC. 2019; 3(3): 229-233
» Abstract » doi: 10.24911/IJMDC.51-1542576396
Cited : 8 times [Click to see citing articles]

Knowledge, attitude, and practice of breast self-examination toward breast cancer among female students at King Saud University in Riyadh, Saudi Arabia
Abdullah Nasser Alomair, Dania Ghazi Felemban, Mohannad Sami Felemban, Jameel Abdullah Awadain, Ammar Saud Altowairqi, Nawaf Fawzan Alfawzan, Fatimah Mohammed Almazayen, Abdulrahman Jalwi Korkoman, Nawaf Saad Alrusayyis
IJMDC. 2020; 4(2): 429-434
» Abstract » doi: 10.24911/IJMDC.51-1576668182
Cited : 8 times [Click to see citing articles]

Population awareness about rheumatoid arthritis in Jazan region, Saudi Arabia
Ahmad Ali Hazzazi, Mohssen Hassen Ageeli, Ahmed Ali Muyidi, Abdulaziz Mohammad Abulgasim, Abdullah Ahmad Yateemi, Nabil Alhakami
IJMDC. 2020; 4(3): 668-675
» Abstract » doi: 10.24911/IJMDC.51-1576010943
Cited : 4 times [Click to see citing articles]

Prevalence and factors associated with depression among health care workers in National Guard Hospital in Riyadh, KSA
Noor Mohammad AlFahhad
IJMDC. 2018; 2(September 2018): 92-96
» Abstract » doi: 10.24911/IJMDC.51-1526306040
Cited : 4 times [Click to see citing articles]

About International Journal of Medicine in Developing Countries

Contact Information

How to cite this article