E-ISSN 1658-7820
 

Original Article

Online Publishing Date:
19 / 01 / 2021

 


Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study

Ali Hussain Alsafar, Hassan Essa Albohamood, Ibrahim Abdullah Alluwaym, Mujtaba Jameel Alzakari, Radi Abdulqader Alobaidi, Mohammad Ali Alawadh, Royes Joseph, Cyril Cyrus.


Abstract
Background: Diabetes mellitus (DM) is the most common chronic endocrine disorder worldwide. Statin therapy remains the cornerstone of the primary prevention option for the management of hypercholesterolemia in patients at risk for atherosclerotic cardiovascular disorder. Despite the pivotal role of statin in the management of hypercholesterolemia, several randomized controlled trials, and observational studies have reported that statins worsen glycemia and increase the risk of New-Onset Diabetes Mellitus (NODM). The objective of this study was to validate the potential risk factors of statin-induced NODM in dyslipidemia patients.
Method: Electronic patient records from the King Fahad Hospital of the University, Imam Abdulrahman Bin Faisal University were screened for patients who have been administered statin for more than 1 year. We retrospectively analyzed the factors affecting the development of DM after statin therapy.
Results: Of the 3,562 statin users 150 had incident diabetes with an incidence rate of 4.2% with a relative risk ratio of 1.91 (95% CI: 1.62-2.26). The overall mean age of the study population was 57.72 ± 14.73, and NODM association with older age was seen. Interestingly, 20 mg dose [odds ratio (OR): 7.3; 95% confidence interval (CI): 4.6-11.7] and early users between 1 and 2 years (OR: 37.2; 95% CI: 21.3-65.0) showed a statistically significant effect on NODM.
Conclusion: This hospital-based survey highlights the clinical necessity of performing diabetes screening before initiation of statin therapy. As the risk of NODM increased in the early stages of statin treatment, clinicians should emphasize the need for lifestyle modification and enlighten the new users of statin about the potential benefits and side effects of statin therapy.

Key words: Statins; Diabetes mellitus; Drug-induced diabetes; Atorvastatin; New-onset diabetes mellitus; Treatment risk paradox.


 
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How to Cite this Article
Pubmed Style

Alsafar AH, Albohamood HE, Alluwaym IA, Alzakari MJ, Alobaidi RA, Alawadh MA, Joseph R, Cyrus C. Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study. IJMDC. 2021; 5(2): 688-694. doi:10.24911/IJMDC.51-1609676604


Web Style

Alsafar AH, Albohamood HE, Alluwaym IA, Alzakari MJ, Alobaidi RA, Alawadh MA, Joseph R, Cyrus C. Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study. https://www.ijmdc.com/?mno=39263 [Access: March 28, 2024]. doi:10.24911/IJMDC.51-1609676604


AMA (American Medical Association) Style

Alsafar AH, Albohamood HE, Alluwaym IA, Alzakari MJ, Alobaidi RA, Alawadh MA, Joseph R, Cyrus C. Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study. IJMDC. 2021; 5(2): 688-694. doi:10.24911/IJMDC.51-1609676604



Vancouver/ICMJE Style

Alsafar AH, Albohamood HE, Alluwaym IA, Alzakari MJ, Alobaidi RA, Alawadh MA, Joseph R, Cyrus C. Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study. IJMDC. (2021), [cited March 28, 2024]; 5(2): 688-694. doi:10.24911/IJMDC.51-1609676604



Harvard Style

Alsafar, A. H., Albohamood, . H. E., Alluwaym, . I. A., Alzakari, . M. J., Alobaidi, . R. A., Alawadh, . M. A., Joseph, . R. & Cyrus, . C. (2021) Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study. IJMDC, 5 (2), 688-694. doi:10.24911/IJMDC.51-1609676604



Turabian Style

Alsafar, Ali Hussain, Hassan Essa Albohamood, Ibrahim Abdullah Alluwaym, Mujtaba Jameel Alzakari, Radi Abdulqader Alobaidi, Mohammad Ali Alawadh, Royes Joseph, and Cyril Cyrus. 2021. Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study. International Journal of Medicine in Developing Countries, 5 (2), 688-694. doi:10.24911/IJMDC.51-1609676604



Chicago Style

Alsafar, Ali Hussain, Hassan Essa Albohamood, Ibrahim Abdullah Alluwaym, Mujtaba Jameel Alzakari, Radi Abdulqader Alobaidi, Mohammad Ali Alawadh, Royes Joseph, and Cyril Cyrus. "Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study." International Journal of Medicine in Developing Countries 5 (2021), 688-694. doi:10.24911/IJMDC.51-1609676604



MLA (The Modern Language Association) Style

Alsafar, Ali Hussain, Hassan Essa Albohamood, Ibrahim Abdullah Alluwaym, Mujtaba Jameel Alzakari, Radi Abdulqader Alobaidi, Mohammad Ali Alawadh, Royes Joseph, and Cyril Cyrus. "Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study." International Journal of Medicine in Developing Countries 5.2 (2021), 688-694. Print. doi:10.24911/IJMDC.51-1609676604



APA (American Psychological Association) Style

Alsafar, A. H., Albohamood, . H. E., Alluwaym, . I. A., Alzakari, . M. J., Alobaidi, . R. A., Alawadh, . M. A., Joseph, . R. & Cyrus, . C. (2021) Statin use and the risk of new-onset diabetes mellitus: a retrospective cohort study. International Journal of Medicine in Developing Countries, 5 (2), 688-694. doi:10.24911/IJMDC.51-1609676604





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