E-ISSN 1658-7820
 
2024, Vol: 8, Issue: 4
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Review Article

Online Publishing Date:
20 / 01 / 2022

 


A systematic review and meta-analysis on efficacy of low dose aspirin on the management of COVID-19

Manal Banaser, Mutaman Jarrar, Ayed Alqahtani, Abdulelah Banaser, Waleed Albaker.


Abstract
COVID-19 pandemic has increased thrombotic risk by 35%. This pandemic led to millions of deaths due to various comorbidities and organ failure. Repurposing aspirin usage to manage COVID-19 hospitalized patients is a logical approach for preventing cardiovascular disease and comorbidities that increase mortality risk. However, several earlier investigations found inconsistent outcomes. This study aims to assess primary and secondary effects in COVID-19 patients with or without aspirin. We performed a multi-database electronic search including Cochrane, Embase, Scopus, and PubMed from date of inception to November 2021 using search terms: (“Coronavirus Disease 2019” OR “COVID-19” OR “SARS-CoV-2” OR “2019-nCoV”) AND (“Acetylsalicylic acid” OR “acetylsalicylate” OR “aspirin” OR “antiplatelet”) AND (“mortality” OR “severe” OR “severity”). Eight retrospective studies met the study criteria comprising 7,171 aspirin users and 8,327 non-aspirin users in COVID- 19. Aspirin administration significantly reduces mortality risk (RR: 0.51, 95% CI: 0.46-0.57, I2 = 85.05, p-value <0.001, τ2 = 0.028, Z-value: -11.44, p-value <0.001). Aspirin used in COVID-19 patients demonstrated reduced bleeding risk (RR: 0.80, 95 CI%: 0.34-1.9) and reduced risk for the necessity of mechanical ventilation (RR: 0.70; 95% CI: 0.54-0.90, I2 = 0%, p-value: 0.41, τ2 = 0%) when compared with COVID-19 patients without aspirin use. The present review found administration of a low dose of aspirin in COVID-19 patients significantly reduced mortality risk.

Key words: Low dose aspirin, mortality, COVID-19, thrombosis, antiplatelet drug


 
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How to Cite this Article
Pubmed Style

Banaser M, Jarrar M, Alqahtani A, Banaser A, Albaker W. A systematic review and meta-analysis on efficacy of low dose aspirin on the management of COVID-19. IJMDC. 2022; 6(3): 526-534. doi:10.24911/IJMDC.51-1640383699

Web Style

Banaser M, Jarrar M, Alqahtani A, Banaser A, Albaker W. A systematic review and meta-analysis on efficacy of low dose aspirin on the management of COVID-19. https://www.ijmdc.com/?mno=117130 [Access: March 27, 2024]. doi:10.24911/IJMDC.51-1640383699

AMA (American Medical Association) Style

Banaser M, Jarrar M, Alqahtani A, Banaser A, Albaker W. A systematic review and meta-analysis on efficacy of low dose aspirin on the management of COVID-19. IJMDC. 2022; 6(3): 526-534. doi:10.24911/IJMDC.51-1640383699


Vancouver/ICMJE Style

Banaser M, Jarrar M, Alqahtani A, Banaser A, Albaker W. A systematic review and meta-analysis on efficacy of low dose aspirin on the management of COVID-19. IJMDC. (2022), [cited March 27, 2024]; 6(3): 526-534. doi:10.24911/IJMDC.51-1640383699


Harvard Style

Banaser, M., Jarrar, . M., Alqahtani, . A., Banaser, . A. & Albaker, . W. (2022) A systematic review and meta-analysis on efficacy of low dose aspirin on the management of COVID-19. IJMDC, 6 (3), 526-534. doi:10.24911/IJMDC.51-1640383699


Turabian Style

Banaser, Manal, Mutaman Jarrar, Ayed Alqahtani, Abdulelah Banaser, and Waleed Albaker. 2022. A systematic review and meta-analysis on efficacy of low dose aspirin on the management of COVID-19. International Journal of Medicine in Developing Countries, 6 (3), 526-534. doi:10.24911/IJMDC.51-1640383699


Chicago Style

Banaser, Manal, Mutaman Jarrar, Ayed Alqahtani, Abdulelah Banaser, and Waleed Albaker. "A systematic review and meta-analysis on efficacy of low dose aspirin on the management of COVID-19." International Journal of Medicine in Developing Countries 6 (2022), 526-534. doi:10.24911/IJMDC.51-1640383699


MLA (The Modern Language Association) Style

Banaser, Manal, Mutaman Jarrar, Ayed Alqahtani, Abdulelah Banaser, and Waleed Albaker. "A systematic review and meta-analysis on efficacy of low dose aspirin on the management of COVID-19." International Journal of Medicine in Developing Countries 6.3 (2022), 526-534. Print. doi:10.24911/IJMDC.51-1640383699


APA (American Psychological Association) Style

Banaser, M., Jarrar, . M., Alqahtani, . A., Banaser, . A. & Albaker, . W. (2022) A systematic review and meta-analysis on efficacy of low dose aspirin on the management of COVID-19. International Journal of Medicine in Developing Countries, 6 (3), 526-534. doi:10.24911/IJMDC.51-1640383699




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