Original Article

IJMDC. 2020; 4(6): 968-974

Correlation Between Technetium-99msestamibi Scans, Intraoperative Findings, and Histopathological Results in Primary and Tertiary Hyperparathyroidism

Authors: Abdullah Thawabeh, Sara Assiri, Shroog Alharthi.

ABSTRACT

Background: Technetium sestamibi imaging focuses on detecting adenomas in primary hyperparathyroidism patients scheduled for parathyroidectomy with unilateral neck exploration. However, its role in the primary resection of tertiary hyperparathyroidism patients is not yet well-defined. This study aims to analyze all data of primary and tertiary hyperparathyroidism patients who underwent parathyroidectomy after the preoperative sestamibi scan. Methodology: A cross-sectional study involved a total of 28 primary and tertiary hyperparathyroidism patients who underwent 99Tc sestamibi imaging before performing parathyroidectomy from January of 2016 to August of 2018. Data collection also involved intraoperative and histopathological findings, and preoperative biochemical values and post-operative calcium levels. Results: A total of 28 patients with a mean age of 53.89 + 14 years and a female predominance (92.9%) were included. In primary hyperparathyroidism, patients 90.5% had true positive sestamibi results and 22.2% had false-positive results, while in tertiary hyperparathyroidism patients, only 9.5% had true positive sestamibi results and 44.4% had false-positive results. Those who underwent unilateral exploration had a mean postoperative calcium level of 2.28+0.21 mmol/l, while those who underwent bilateral neck exploration showed a mean postoperative calcium level of 2.01+ 2.44 mmol/l. Conclusion: Sestamibi scanning is a highly beneficial imaging technique for localizing adenomas in primary hyperparathyroidism patients. This method can facilitate unilateral surgical approach and was found to decrease postoperative hypocalcemia. However, the usefulness of sestamibi scans in the primary resection of tertiary hyperparathyroidism patients is limited, and it does not have any significance in changing the surgical approach.

Keywords:
Hyperparathyroidism, sestamibi scan, adenoma, Saudi Arabia, parathyroidectomy.


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Correlation Between Technetium-99msestamibi Scans, Intraoperative Findings, and Histopathological Results in Primary and Tertiary Hyperparathyroidism


Authors
Abdullah Thawabeh
Department of General Surgery, Al-Hada armed forces hospital, Taif City, Saudi Arabia
PubMed articlesGoogle scholar articles

Sara Assiri
College of Medicine, Taif University, Taif City, Saudi Arabia
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Shroog Alharthi
College of Medicine, Taif University, Taif City, Saudi Arabia.
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Correspondence to:
. Sara Assiri, College of Medicine, Taif University, Taif City, Saudi Arabia.; saraassiriiii@gmail.com

Publication history
Received 16 Apr 2020
Accepted 05 May 2020
Published online 17 May 2020
Published in print 25 Jun 2020

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Pubmed Style

Thawabeh A, Assiri S, Alharthi S. Correlation Between Technetium-99msestamibi Scans, Intraoperative Findings, and Histopathological Results in Primary and Tertiary Hyperparathyroidism. IJMDC. 2020; 4(6): 968-974. doi:10.24911/IJMDC.51-1586902477


Web Style

Thawabeh A, Assiri S, Alharthi S. Correlation Between Technetium-99msestamibi Scans, Intraoperative Findings, and Histopathological Results in Primary and Tertiary Hyperparathyroidism. http://www.ijmdc.com/?mno=99368 [Access: July 14, 2020]. doi:10.24911/IJMDC.51-1586902477


AMA (American Medical Association) Style

Thawabeh A, Assiri S, Alharthi S. Correlation Between Technetium-99msestamibi Scans, Intraoperative Findings, and Histopathological Results in Primary and Tertiary Hyperparathyroidism. IJMDC. 2020; 4(6): 968-974. doi:10.24911/IJMDC.51-1586902477


Vancouver/ICMJE Style

Thawabeh A, Assiri S, Alharthi S. Correlation Between Technetium-99msestamibi Scans, Intraoperative Findings, and Histopathological Results in Primary and Tertiary Hyperparathyroidism. IJMDC. (2020), [cited July 14, 2020]; 4(6): 968-974. doi:10.24911/IJMDC.51-1586902477


Harvard Style

Thawabeh, A., Assiri, . S. & Alharthi, . S. (2020) Correlation Between Technetium-99msestamibi Scans, Intraoperative Findings, and Histopathological Results in Primary and Tertiary Hyperparathyroidism. IJMDC, 4 (6), 968-974. doi:10.24911/IJMDC.51-1586902477


Turabian Style

Thawabeh, Abdullah, Sara Assiri, and Shroog Alharthi. 2020. Correlation Between Technetium-99msestamibi Scans, Intraoperative Findings, and Histopathological Results in Primary and Tertiary Hyperparathyroidism. International Journal of Medicine in Developing Countries, 4 (6), 968-974. doi:10.24911/IJMDC.51-1586902477


Chicago Style

Thawabeh, Abdullah, Sara Assiri, and Shroog Alharthi. "Correlation Between Technetium-99msestamibi Scans, Intraoperative Findings, and Histopathological Results in Primary and Tertiary Hyperparathyroidism." International Journal of Medicine in Developing Countries 4 (2020), 968-974. doi:10.24911/IJMDC.51-1586902477


MLA (The Modern Language Association) Style

Thawabeh, Abdullah, Sara Assiri, and Shroog Alharthi. "Correlation Between Technetium-99msestamibi Scans, Intraoperative Findings, and Histopathological Results in Primary and Tertiary Hyperparathyroidism." International Journal of Medicine in Developing Countries 4.6 (2020), 968-974. Print. doi:10.24911/IJMDC.51-1586902477


APA (American Psychological Association) Style

Thawabeh, A., Assiri, . S. & Alharthi, . S. (2020) Correlation Between Technetium-99msestamibi Scans, Intraoperative Findings, and Histopathological Results in Primary and Tertiary Hyperparathyroidism. International Journal of Medicine in Developing Countries, 4 (6), 968-974. doi:10.24911/IJMDC.51-1586902477


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