IJMDC. 2020; 4(4): 844-847

Sirolimus treatment over a period of two-years for CLOVES syndrome—a case report

Authors: Alaa Alsaegh, Saad Alajlan, Hatoon Almaziad.

ABSTRACT

Background: CLOVES syndrome (CS) is a rare genetic disorder caused by a mutation in PIK3CA gene. Characteristics of CS include fatty overgrowth and lymphatic malformations in the body. Case Presentation: The study reported a case of CS in a 6-year-old boy having tissue hypertrophy in the right lower limb, a capillary venous malformation in the buttock and right lower limb, enlargement of feet with bilateral macrodactyly, resulting in walking difficulty. The patient was diagnosed to have these symptoms by birth. Over a period of 2 years, the patient was subjected to Sirolimus treatment, the effectiveness of the treatment had been consolidated in this case report. In 2012, the patient underwent venogram, diode laser, and sclerotherapy for the bleeding. In 2016, the patient was started on Sirolimus drug in controlled doses and the patient’s condition was stabilized. The imaging techniques showed signs of improvement of the infiltrative venolymphatic malformation. The therapy was continued until 2019 and the tissue growth was controlled. Conclusion: Sirolimus could be an ideal therapeutic agent for CS when administered in controlled doses

Keywords:
CLOVES syndrome, Sirolimus, tissue hypertrophy, capillary venous malformation, PIK3CA


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Sirolimus treatment over a period of two-years for CLOVES syndrome—a case report


Authors
Alaa Alsaegh
Medical Intern, King Faisal Specialist Hospital Research Centre, Al-Faisal University, Riyadh, Saudi Arabia
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Saad Alajlan
Consultant, Assistant Professor, Department of Dermatology, King Faisal Specialist Hospital Research Centre, Al-Faisal University, Riyadh, Saudi Arabia
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Hatoon Almaziad
Resident, Department of Dermatology, King Faisal Specialist Hospital Research Centre, Al-Faisal University, Riyadh, Saudi Arabia.
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Correspondence to:
. Alaa Ahmed Alsaegh, Medical Intern, King Faisal Specialist Hospital Research Centre, Al-Faisal University, Riyadh, Saudi Arabia.; alaa.a.alsaegh@gmail.com

Publication history
Received 17 Jan 2020
Accepted 07 Mar 2020
Published online 20 Mar 2020
Published in print 11 Apr 2020

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Pubmed Style

Alsaegh A, Alajlan S, Almaziad H. Sirolimus treatment over a period of two-years for CLOVES syndrome—a case report. IJMDC. 2020; 4(4): 844-847. doi:10.24911/IJMDC.51-1579171814


Web Style

Alsaegh A, Alajlan S, Almaziad H. Sirolimus treatment over a period of two-years for CLOVES syndrome—a case report. http://www.ijmdc.com/?mno=82278 [Access: July 14, 2020]. doi:10.24911/IJMDC.51-1579171814


AMA (American Medical Association) Style

Alsaegh A, Alajlan S, Almaziad H. Sirolimus treatment over a period of two-years for CLOVES syndrome—a case report. IJMDC. 2020; 4(4): 844-847. doi:10.24911/IJMDC.51-1579171814


Vancouver/ICMJE Style

Alsaegh A, Alajlan S, Almaziad H. Sirolimus treatment over a period of two-years for CLOVES syndrome—a case report. IJMDC. (2020), [cited July 14, 2020]; 4(4): 844-847. doi:10.24911/IJMDC.51-1579171814


Harvard Style

Alsaegh, A., Alajlan, . S. & Almaziad, . H. (2020) Sirolimus treatment over a period of two-years for CLOVES syndrome—a case report. IJMDC, 4 (4), 844-847. doi:10.24911/IJMDC.51-1579171814


Turabian Style

Alsaegh, Alaa, Saad Alajlan, and Hatoon Almaziad. 2020. Sirolimus treatment over a period of two-years for CLOVES syndrome—a case report. International Journal of Medicine in Developing Countries, 4 (4), 844-847. doi:10.24911/IJMDC.51-1579171814


Chicago Style

Alsaegh, Alaa, Saad Alajlan, and Hatoon Almaziad. "Sirolimus treatment over a period of two-years for CLOVES syndrome—a case report." International Journal of Medicine in Developing Countries 4 (2020), 844-847. doi:10.24911/IJMDC.51-1579171814


MLA (The Modern Language Association) Style

Alsaegh, Alaa, Saad Alajlan, and Hatoon Almaziad. "Sirolimus treatment over a period of two-years for CLOVES syndrome—a case report." International Journal of Medicine in Developing Countries 4.4 (2020), 844-847. Print. doi:10.24911/IJMDC.51-1579171814


APA (American Psychological Association) Style

Alsaegh, A., Alajlan, . S. & Almaziad, . H. (2020) Sirolimus treatment over a period of two-years for CLOVES syndrome—a case report. International Journal of Medicine in Developing Countries, 4 (4), 844-847. doi:10.24911/IJMDC.51-1579171814


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